Preparation and characterisation of porous calcium phosphate bone cement as antibiotic carrier

Hesaraki, Saeed; Nemati, R.; Nosoudi, Nasim

doi:10.1179/174367608x353656

Cited by 21 publications

(19 citation statements)

References 46 publications

(57 reference statements)

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“…5 Mouldability, low temperature self-setting behaviour, bioactivity, bioresorbability, biodegradation and great bone bonding properties of these cements, along with the above mentioned features, make them exceptional candidates for other applications, such as drug delivery systems. 6 However, they also have a few shortcomings, and some additives should be applied to their powder or liquid phase to improve the intrinsic qualities of these cements. Low mechanical properties, poor injectability, long setting time and washout behaviour are some of their drawbacks.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterisation of calcium phosphate–hyaluronic acid nanocomposite bone cement

Ahmadzadeh-Asl

Hesaraki

Zamanian

2011

Advances in Applied Ceramics

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In this study, calcium phosphate cements (CPCs) were prepared by using hyaluronic acid (HA) solutions with two different molecular weights. The physical, physicochemical and structural properties of these cements were characterised and compared with those of conventional CPC as control group. Results revealed that the long setting time and the low compressive strength of the CPC could be improved drastically by using HA in the cement composition, in a molecular weight dependent manner. The HA polymer has also a promising effect on cement injectability, which is more considerable in high molecular weight HA. The X-ray diffraction patterns of set cements showed that, in both control group and HA containing cements, primary reactant components were completely converted to nanostructured apatite after soaking in simulated body fluid. This study suggests that calcium phosphate nanocomposite cement obtained by HA solution can be successfully used as injectable bone filler material.

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Section: Introductionmentioning

confidence: 99%

Preparation and characterisation of calcium phosphate–hyaluronic acid nanocomposite bone cement

Ahmadzadeh-Asl

Hesaraki

Zamanian

2011

Advances in Applied Ceramics

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“…Setting of calcium orthophosphate cements and concretes occurs mostly within the initial ~ 6 hours, yielding a ~ 80% conversion to the final products and a compressive strength of 40 -60 MPa. A hardening rate is strongly influenced by a powder to liquid ratio, as well as by addition of other chemicals [156,[514][515][516][517][518][519][520][521][522]. Despite a large number of formulations, all calcium orthophosphate cements can only form two different end products: CDHA and DCPD [156,515,516].…”

Section: Cements and Concretesmentioning

confidence: 99%

“…The need of bioceramics for minimal invasive surgery has induced the development of a concept of self-setting formulations consisting of only calcium orthophosphates to be applied as injectable and/or mouldable bone substitutes [156,400,401,418,475,[514][515][516][517][518][519][520][521][522]. In addition, there are reinforced formulations, which, in a certain sense, might be defined as calcium orthophosphate concretes [516].…”

Section: Cements and Concretesmentioning

confidence: 99%

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Untitled

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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“…Different types of drugs have been loaded in CPCs since they are possible matrixes for loading different types of drugs and deliver them locally [12]. Bisphosphonates are prescribed for osteoclastmediated diseases such as osteoporosis, and Paget disease.…”

Section: -mentioning

confidence: 99%

Calcium Phosphate/Etidronate Disodium Biocement: Etidronate, Retarder or Accelerator

Nosoudi¹,

Hasanzadeh²,

Holman³

et al. 2014

Nano BioMed ENG

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Bisphosphonate release from calcium phosphate cement has been investigated. We hypothesized that local delivery of bisphosphonate from the calcium phosphate cement improves the mechanical properties. Different samples with different concentration of Etidronate disodium have been made and analyzed. We observed a dual behavior from Etidronate in retarding and accelerating the setting of calcium phosphate cement in low and high concentration respectively. After soaking samples in simulated body fluid, an optimum concentration of Etidronate disodium was added to the calcium phosphate paste in order to achieve the best mechanical properties. Scanning electron microscopy (SEM) showed the formation of hydroxyapatite crystals. X-ray diffraction (XRD) analysis was used to determine hydroxyapatite peaks on the surface of the bio-cement, which confirms the hydroxyapatite formation.

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Preparation and characterisation of porous calcium phosphate bone cement as antibiotic carrier

Cited by 21 publications

References 46 publications

Preparation and characterisation of calcium phosphate–hyaluronic acid nanocomposite bone cement

Preparation and characterisation of calcium phosphate–hyaluronic acid nanocomposite bone cement

Untitled

Calcium Phosphate/Etidronate Disodium Biocement: Etidronate, Retarder or Accelerator

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