Preparation and application of chitosan nanoparticles and nanofibers

Zhao, Liming; Shi, Lu-E; Zhang, Zhiliang; Chen, Jianmin; Shi, Daxin; Yang, Jie; Tang, Zhen‐Xing

doi:10.1590/s0104-66322011000300001

Cited by 205 publications

(71 citation statements)

References 71 publications

(52 reference statements)

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“…The solutions were lyophilized. Here, microcarriers are formed due to the interaction of oppositely charged cross-linking agent (Zhao et al 2011). …”

Section: Methodsmentioning

confidence: 99%

Chelators influenced synthesis of chitosan–carboxymethyl cellulose microparticles for controlled drug delivery

et al. 2016

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In this study, polyphenolic curcumin is entrapped within microcomposites made of biopolymers chitosan (CS) and carboxymethyl cellulose (CMC) formulated by ionic gelation method. Here, different concentrations of two chelating agents, barium chloride and sodium tripolyphosphate, are used to make microcomposites. Thus, the synthesized microparticles were characterized by FTIR, and their surface morphology was studied by SEM. Drug encapsulation efficiency and the drug release kinetics of CS-CMC composites are also studied. The produced microcomposites were used to study antibacterial activity in vitro.

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“…The solutions were lyophilized. Here, microcarriers are formed due to the interaction of oppositely charged cross-linking agent (Zhao et al 2011). …”

Section: Methodsmentioning

confidence: 99%

Chelators influenced synthesis of chitosan–carboxymethyl cellulose microparticles for controlled drug delivery

et al. 2016

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“…Nanoparticles are defined as particulate dispersions or solid particles with a size in the range of 1-1000 nm [16,17]. The physical and biological properties of nanomaterials are unique and differ depending on their corresponding bulk material, making these entities an intense focus of recent studies.…”

Section: Introductionmentioning

confidence: 99%

“…Several attempts have been made to synthesize chitosan nanoparticles from different chitosan sources. Different methods, such as the microemulsion method, reverse micellar method, self-assembling method and ionic gelation have been used to prepare chitosan nanoparticles [16,19].…”

Section: Introductionmentioning

confidence: 99%

“…The mechanism of chitosan nanoparticle formation is based on the electrostatic interaction between amine group of chitosan and negatively charged group of polyanion such as tripolyphosphate. This technique offers a simple and mild preparation method in the aqueous environment [16,19]. Consequently, this method was adopted in this work to synthesize cowry shell based chitosan /gum arabic nanoparticles for bone regeneration.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and Characterization of Chitosan/Gum Arabic Nanoparticles for Bone Regeneration

Ibekwe¹,

Oyatogun²,

Esan³

et al. 2017

AJMSE

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Chitosan /gum arabic nanoparticles (C/G)have been prepared by ionic gelation method. This was with a view to enhance the mechanical properties and its application as bone graft scaffold. The cowry shells were washed, dried, pulverized and subsequently sieved with mesh No. 60, size 250 µm. It was deproteinized, Chitin was isolated from the synthesis by demineralising in 0.5 M Hydrochloric acid, and subsequently deacetylated by the addition of 40% (W/V) of Sodium hydroxide to synthesize chitosan. The raw chitosan was purified using 2% (v/v) acetic acid solution. The synthesized chitosan and gum arabic, a product of Acacia tree, were used to prepare chitosan/gum arabic nanoparticles by ionic gelation method. Mechanical characterization was carried out on the synthesized material using universal testing machine. Analysis of the chemical composition was carried out using Fourier transform infrared spectrometer (FTIR) and X-Ray fluorescence, (XRF). Furthermore, the morphology of the materials were studied using scanning electron microscopy, SEM and the dimension of the nanoparticles were characterized using transmission electron microscopy (TEM). Finally, an attempt was made to ascertain its suitability for bone regeneration. The FTIR spectra result confirmed that the nanoparticle was actually a derivative of chitosan by the observed shift in the peak 3462 to 3404cm- -1 and 712 cm -1 on C/G nanoparticles spectrum were similar to the native chitosan spectrum which shows that there was no change in the main backbone of chitosan structure. The scanning electron microscopy (SEM) study revealed chitosan as polymeric rods, while the chitosan /gum arabic nanoparticles in aggregate. The TEM was to confirm nanoparticles of average size of 200nm. The ultimate compressive strength was found to have increased by 78.21%, the Young Modulus by 54.4 % and percentage elongation by 7%. In overall assessment, mechanical properties of the chitosan/gum arabic nanoparticles were better than native chitosan. The study concluded that crosslinking of chitosan with gum arabic to form its nanoparticles derivative improved the mechanical properties of chitosan and consequently its application as a bone graft substitute for bone regeneration.

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“…One of the most used drying methods has been the spray drying, which can be used on active pharmaceutical raw material drying, including molecules (Sansone et al, 2009), proteins (Gonnissen et al, 2008) and plant extracts (Couto, 2005;Gallo et al, 2011). In addition, this technique has also been used in the development of microparticles or nanoparticles of active principles (Zhao et al, 2011;Sansone et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Influence of process conditions on the physicochemical characteristics of cumaru (Amburana cearensis) powder produced by spray drying

Araruna¹,

Silva²,

Canuto³

et al. 2013

Rev. bras. farmacogn.

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Abstract:The aim of the work was to study the spray-drying of ethanolic extract from Amburana cearensis (Allemão) A.C. Sm., Fabaceae, in order to obtain powders with better pharmacological and technological properties for herbal medicine. A 2 3 fractional factorial statistical design was used to find adequate spray-drying operating conditions (inlet air temperature; feed flow rate and air flow rate) to produce A. cearensis powder with adequate concentration of active principles (amburoside and coumarin), low moisture content and high process yield. The HPLC analyses showed that the spray-drying powder of A. cearensis production did not cause alterations in the chromatographic profile when related to the fluid extract. The most significant factor that affected the amburoside concentration was air flow rate, while the concentration of coumarin, a thermolabile molecule, was influenced mainly by inlet air temperature. The moisture content of the spray-drying powder of A. cearensis varied from 3.72 to 5.85% (w/w), while the maximal process yield was 41.1% (w/w). The present study demonstrates for the first time the best operating conditions to produce A. cearensis extract powder that were adequate when related to the coumarin and amburoside concentrations and moisture content. However, additional studies are still needed to improve mainly it technological characteristics.

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Preparation and application of chitosan nanoparticles and nanofibers

Cited by 205 publications

References 71 publications

Chelators influenced synthesis of chitosan–carboxymethyl cellulose microparticles for controlled drug delivery

Chelators influenced synthesis of chitosan–carboxymethyl cellulose microparticles for controlled drug delivery

Synthesis and Characterization of Chitosan/Gum Arabic Nanoparticles for Bone Regeneration

Influence of process conditions on the physicochemical characteristics of cumaru (Amburana cearensis) powder produced by spray drying

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