Preoperative Uracil, Tegafur, and Concomitant Radiotherapy in Operable Rectal Cancer: A Phase II Multicenter Study With 3 Years' Follow-Up

Fernández-Martos, Carlos; Aparicio, Jorge; Bosch, C.; Torregrosa, Marilo; Campos, Juan; Garcera, S.; Vicent, J. M.; Maestu, Inmaculada; Climent, Miguel Ángel; Mengual, J.; Tormo, A.; Hernández, Ana Lluch; Estevan, Rafael; Richart, Jose Maria; Viciano, Vicente Masip; Uribe, Natalia; Campos, Jorge Gutierrez; Puchades, Ramón; Arlandis, Francisco; Almenar, D.

doi:10.1200/jco.2004.11.124

Cited by 63 publications

(45 citation statements)

References 26 publications

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“…infusion of 5-FU. UFT has also been evaluated as a drug for CRT [20,21]. It is a combination of uracil and tegafur at 4:1 molar concentration and an oral anticancer agent with good absorption at the small intestine [22].…”

Section: Discussionmentioning

confidence: 99%

Concurrent chemoradiation therapy with low-dose CDDP and UFT for glottic carcinomas: Evaluation using the sixth edition of the UICC TNM staging system

et al. 2006

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Section: Discussionmentioning

confidence: 99%

Concurrent chemoradiation therapy with low-dose CDDP and UFT for glottic carcinomas: Evaluation using the sixth edition of the UICC TNM staging system

et al. 2006

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“…Esta permite disminuir la toxicidad y reducir el tamaño del tumor, con lo que se mejoran los resultados con respecto al tratamiento postoperatorio y se incrementa el porcentaje de pacientes con cirugía conservadora del esfínter (del Valle et al, 2003;Grann et al, 2001). En el Servicio de Oncología Médica del Hospital Universitario y Politécnico La Fe de Valencia entre el año 2000 y 2004 se utilizó quimioterapia oral con UFT (asociado a oxaliplatino) y radioterapia preoperatoria en estos casos, con excelentes resultados (Fernández-Martos et al, 2004).…”

Section: Tratamientounclassified

Evaluación de las alteraciones psicológicas y de la calidad de vida en pacientes con cáncer colorrectal localizado

Pérez

2016

Psicooncología

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“…Phase II studies have shown that the UFT/radiotherapy combination is effective and well tolerated in the preoperative treatment of rectal cancer [7][8][9][10][11]. On the other hand, CDHP (gimeracil), a component of S-1, has potent radiosensitizing property [12].…”

Section: Introductionmentioning

confidence: 99%

A Phase II Trial of Preoperative Chemoradiotherapy with Oral DPD-Inhibitory Fluoropyrimidines in Patients with Advanced Rectal Cancer

Hotchi¹,

Okitsu²,

Miura³

et al. 2012

JCT

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Background: Preoperative chemoradiotherapy (CRT) with 5-FU has been widely used to improve local control of disease and to preserve anal sphincter in the treatment of rectal cancer. UFT and S-1 as oral dihydropyrimidine dehydrogenase (DPD)-inhibitory fluoropyrimidines enhance the therapeutic effect of 5-FU by modulating its metabolic pathways. The purpose of this study was to evaluate the efficacy and toxicity of CRT using UFT versus S-1 in patients with locally advanced rectal cancer. Methods: Fifty-nine patients who received preoperative CRT (40 Gy radiotherapy) were randomly assigned to either UFT or S-1 groups. UFT and S-1 were administered during the radiotherapy course. Response to CRT was determined using a histopathologic examination and RECIST of surgically resected specimens and classified as responders (CR, PR and Grade 2, 3) or nonresponders (SD, PD and Grade 0, 1). Results: All patients were randomly allocated to S-1 group (n = 30) or UFT group (n = 29). Pathological response rate (Grade 2 and Grade 3) was 57% in the S-1 group and 45% in the UFT group (p = 0.36). Pathological complete response (CR) rate (Grade3) was 7% in the S-1 group and 4% in the UFT group (p = 0.98). There was no statistically significant difference between the two groups in regard to the response rate of RECIST (p = 0.52). There was no statistically significant difference between the groups based on the downstaging rate, resection of tumor, sphincter preservation and marginal invasion. The incidence of Grade 3 diarrhea was significantly more frequent in the S-1 group (7%) compared with the UFT group (0%) (p = 0.02). Conclusion: The results supported the conclusion that CRT using UFT or S-1 is effective and feasible for patients with locally advanced rectal cancer.

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Preoperative Uracil, Tegafur, and Concomitant Radiotherapy in Operable Rectal Cancer: A Phase II Multicenter Study With 3 Years' Follow-Up

Abstract: UFT combined with RT is safe and effective. In resectable rectal cancer, if preoperative treatment is considered, this approach can be an option.

Cited by 63 publications

References 26 publications

Concurrent chemoradiation therapy with low-dose CDDP and UFT for glottic carcinomas: Evaluation using the sixth edition of the UICC TNM staging system

Concurrent chemoradiation therapy with low-dose CDDP and UFT for glottic carcinomas: Evaluation using the sixth edition of the UICC TNM staging system

Evaluación de las alteraciones psicológicas y de la calidad de vida en pacientes con cáncer colorrectal localizado

A Phase II Trial of Preoperative Chemoradiotherapy with Oral DPD-Inhibitory Fluoropyrimidines in Patients with Advanced Rectal Cancer

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