Concurrent chemoradiation therapy with low-dose CDDP and UFT for glottic carcinomas: Evaluation using the sixth edition of the UICC TNM staging system

Murakami, Ryuji; Nishimura, Ryuichi; Baba, Yuji; Yumoto, Eiji; Oya, Natsuo; Yamashita, Yasuyuki

doi:10.1080/02841860500490269

Cited by 18 publications

(10 citation statements)

References 24 publications

(25 reference statements)

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“…Another approach is the use of concurrent chemotherapy. Nevertheless, there are some data showing improvement of LC by platinum/5FU based regimens [27,28] but others showed conflicting results [29,30]. …”

Section: Discussionmentioning

confidence: 99%

Definitive radiotherapy for early stage glottic cancer by 6 MV photons

Tong

Ngan

et al. 2012

Head Neck Oncol

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PurposeTo evaluate the clinical outcome of early glottic cancer (GC) treated by primary radiotherapy (RT) with 6 MV photons.Methods and materialsWe retrospectively reviewed the medical records of 695 consecutive patients with T1N0 and T2N0 GC treated between 1983 and 2005 by RT in our institution. Clinical outcome in terms of local control (LC), overall survival (OS) and cause- specific survival (CSS) rate were evaluated.ResultsThe median follow-up time was 10.5 years. The 10-year actuarial LC rates were as follows: T1A, 91%; T1B, 87%; T2, 77%. The 10-year OS were as follows: T1, 74.2%; T2, 70.7%. The 10-year CSS were as follows: T1, 97.7%; T2, 97.1%.Poorly differentiated histology and tumor biologically effective dose < 65 Gy15 were adverse factors in both LC of T1 and T2 disease. Involvement of anterior commissure was an adverse factor in both LC and CSS of T1 disease. Subglottic extension was associated with poor LC in T2 disease whereas hemoglobin <13.0 was associated with poor LC and CSS of T2 disease.ConclusionPrimary RT remains an option among the various standard treatments for early GC. Clinical treatment outcome by 6MV photons is similar and comparable to historic data of Cobalt-60 and 2 MV photons.

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Section: Discussionmentioning

confidence: 99%

Definitive radiotherapy for early stage glottic cancer by 6 MV photons

Tong

Ngan

et al. 2012

Head Neck Oncol

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“…55 The use of chemotherapy in organ preservation protocols, specifically for T2 lesions, is currently under investigation. [56][57][58] Although initial reports appear promising, the use of radiotherapy alone for treatment of T2 lesions remains widespread, and the effect on outcomes of T2a vs T2b lesions remains unknown.…”

Section: Commentmentioning

confidence: 99%

Meta-analysis of Impaired Vocal Cord Mobility as a Prognostic Factor in T2 Glottic Carcinoma

McCoul¹,

Har‐El²

2009

Arch Otolaryngol Head Neck Surg

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This meta-analysis indicates that impaired vocal cord mobility has a negative impact on local disease control and ultimate disease control in patients receiving primary radiotherapy for the treatment of T2 glottic carcinoma. We recommend that the subdivision of glottic cancer to T2a and T2b be reviewed and considered by the American Joint Committee on Cancer for inclusion in the Cancer Staging Manual.

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“…Between 1992 and 1998, all 9 patients were treated with RT alone. Between 1999 and 2005, we performed concurrent low-dose CRT with low-dose cisplatin and UFT in 23 patients [ 6 ]. To receive this treatment, the patients were required to be 20–80 years of age, have an Eastern Cooperative Oncology Group performance status (PS) of 0–2, a life expectancy of at least 3 months, adequate hematolotic (WBC ≥ 4000/mm 3 , Hb ≥ 10 g/dl, Plts ≥ 100 000/mm 3 ) and renal (Cr ≤ 1.2 mg/dl, CCr ≥ 60 ml/min) function, no severe complications, and provide informed consent.…”

Section: Methodsmentioning

confidence: 99%

“…The median field size was 36 cm 2 (range: 25–49 cm 2 , corresponding to 5 × 5–7 × 7 cm). After the delivery of 40 Gy, otolaryngologists and radiation oncologists, by consensus, performed interim assessment to evaluate tumor regression from endoscopic and radiological examinations [ 6 , 22 ]. In 10 patients, the tumors showed no regression and surgery was performed: total laryngectomy ( n = 4) and laryngeal preservation surgery ( n = 6).…”

Section: Methodsmentioning

confidence: 99%

“…Although the T3 category has changed, the optimal clinical target volume (CTV) of ENI for T3N0 disease without cord fixation, which was formerly treated as a T1-2N0 disease, is not fully discussed. Before the introduction of the UICC sixth edition, we reported the existence of the invasion of the paraglottic space and inner cortex of the thyroid cartilage [ 5 , 6 ]. In the present study, we investigated the optimal CTV of ENI for T3N0 disease without cord fixation by evaluating the regional failure based on our hospital’s database.…”

Section: Introductionmentioning

confidence: 99%

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Radiotherapy for T3N0 glottic carcinoma without cord fixation: elective nodal irradiation or not?

Toya

Murakami

et al. 2017

Oncotarget

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BackgroundAlthough the T3 category has been changed in the sixth edition of the TNM staging system proposed by the Union for International Cancer Control (UICC), the appropriate clinical target volume (CTV) of elective nodal irradiation (ENI) for T3N0 glottic carcinoma without cord fixation, which was formerly treated as a T1-2N0 disease, is not fully discussed.Materials and MethodsWe retrospectively analyzed 64 patients staged or restaged as T3N0 disease without cord fixation. All patients received irradiation to the primary lesion alone using opposed lateral fields. Surgery was performed in 10 patients without tumor regression after the delivery of 40 Gy. The other 54 patients received a median total dose of 66 Gy. Concurrent chemoradiotherapy (CRT) with low-dose cisplatin and UFT (low-dose CRT) and docetaxel, cisplatin, and 5-fluorouracil (TPF-CRT) were performed in 23 and 19 patients, respectively.ResultsEighteen (28.1%) patients suffered treatment failure; all were recorded as local failure alone. The 5-year local control rates for RT alone, low-dose CRT, and TPF-CRT groups were 51.7%, 61.6%, and 93.8%, respectively (p = 0.027). The 5-year laryngeal preservation rates for RT alone, low-dose CRT, and TPF-CRT groups were 57.4%, 81.6%, and 89.5%, respectively (p = 0.048).ConclusionsThe rate of regional failure was zero when irradiating the primary lesion alone using opposed lateral fields. This treatment technique covers the most level III regions; hence, CTV for ENI should include level III alone.

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Concurrent chemoradiation therapy with low-dose CDDP and UFT for glottic carcinomas: Evaluation using the sixth edition of the UICC TNM staging system

Cited by 18 publications

References 24 publications

Definitive radiotherapy for early stage glottic cancer by 6 MV photons

Definitive radiotherapy for early stage glottic cancer by 6 MV photons

Meta-analysis of Impaired Vocal Cord Mobility as a Prognostic Factor in T2 Glottic Carcinoma

Radiotherapy for T3N0 glottic carcinoma without cord fixation: elective nodal irradiation or not?

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