Prenatal methotrexate exposure delays onset of low Mg2+-induced epileptiform discharges in the entorhinal cortex

Kábová, Radka; Velı́šek, Libor

doi:10.1016/s0165-3806(00)00085-7

Cited by 2 publications

(3 citation statements)

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“…50 Similarly, there was an increased resistance to low Mg 2+ -induced epileptiform activity in slices from prenatally MTX-exposed rats. 51 There was no sex difference in these effects of prenatal MTX. Morphologically, we observed increased cellularity in parts of the cortex 51 as well as clusters of GABAergic cells in the neocortex (FIG.…”

Section: Examples Of Models Of Prenatal Drug Exposurementioning

confidence: 93%

“…If a single dose of 5 mg/kg was administered on E15, the offspring invariably demonstrated increased resistance to evoked seizures, i.e., this exposure had anticonvulsant features 50 . Similarly, there was an increased resistance to low Mg 2+ ‐induced epileptiform activity in slices from prenatally MTX‐exposed rats 51 . There was no sex difference in these effects of prenatal MTX.…”

Section: Introductionmentioning

confidence: 98%

“…There was no sex difference in these effects of prenatal MTX. Morphologically, we observed increased cellularity in parts of the cortex 51 as well as clusters of GABAergic cells in the neocortex ( 1).…”

Section: Introductionmentioning

confidence: 99%

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CNS Aspects of Prenatal Drug Exposure

Velı́šek

2006

Annals of the New York Academy of Sciences

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Studies of the effects of prenatal exposure (to drugs or environmental factors) on postnatal brain morphology and function have an important role in assessing adverse effects of prenatal administration of corticosteroids in obstetrics, in studying the impairment of the offspring due to maternal drug abuse, as well as in studies of the influence of other environmental factors (such as toxins or stress). Timing, duration, and dose of the prenatal exposure play a significant role in the postnatal expression of the impact. However, data interpretation may be complicated by additional factors. As mixed litters of prenatally exposed subjects are evaluated, significant differences between males and females may occur. Additionally in females, cyclical changes in ovarian steroids may interfere with the effects of prenatal impact. Developmental differences may be also present, and data from infant, juvenile, prepubertal, and adult individuals cannot be simply compared. Finally, prenatal treatment is a stressful event and may present itself as prenatal stress, misguiding the interpretation. Postnatal environmental factors in raising the offspring, such as housing, maternal care, light-dark cycle, and weaning age can also change the data in such a way, which makes comparisons between different research laboratories impossible.

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Section: Examples Of Models Of Prenatal Drug Exposurementioning

confidence: 93%

Section: Introductionmentioning

confidence: 98%

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CNS Aspects of Prenatal Drug Exposure

Velı́šek

2006

Annals of the New York Academy of Sciences

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Long‐term Changes in Postnatal Susceptibility to Pilocarpine‐induced Seizures in Rats Exposed to Gamma Radiation at Different Stages of Prenatal Development

2003

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Summary:Purpose: To determine whether brains irradiated at different stages of prenatal development also have different postnatal susceptibility to seizures evoked by pilocarpine.Methods: Pregnant Wistar rats were exposed to a single 1.0-Gy dose of gamma rays on gestation days 13, 15, 17, or 19 (E13, E15, E17, and E19, respectively). On postnatal day 60, their offspring received i.p. pilocarpine injections to evoke status epilepticus. Behavior of the animals was observed continuously for 6 h after the injection, and motor manifestations of seizure activity were rated, and survival times recorded. After 7-day survival, the animals were killed, and their brains were weighed.Results: The average brain weight of animals exposed to irradiation at earlier prenatal stages (E13 or E15) was significantly lower than that after irradiation on E17 or E19. However, effects of the irradiation on the susceptibility to pilocarpine-induced seizures were quite opposite. The intensity of status epilepticus evoked in rats irradiated on E13 or E15 was significantly lower than that in nonirradiated controls or in those irradiated on E17 or E19. Moreover, after irradiation on E13 or E15, survival of the animals was significantly higher in relation not only to other irradiated groups but also to the controls.Conclusions: The results suggest than the extent of neuronal deficit, even if relatively greater, cannot always lead to higher susceptibility of the dysplastic brain to seizures. Functional consequences of the deficit, even if its magnitude is relatively smaller but involving specific brain areas, appear to be critical for the epileptogenesis.

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Prenatal methotrexate exposure delays onset of low Mg2+-induced epileptiform discharges in the entorhinal cortex

Cited by 2 publications

References 22 publications

CNS Aspects of Prenatal Drug Exposure

CNS Aspects of Prenatal Drug Exposure

Long‐term Changes in Postnatal Susceptibility to Pilocarpine‐induced Seizures in Rats Exposed to Gamma Radiation at Different Stages of Prenatal Development

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