Prenatal exposure to household pets influences fetal immunoglobulin E production

Aichbhaumik, Niladri; Zoratti, Edward M.; Strickler, Ronald C.; Wegienka, Ganesa; Ownby, Dennis R.; Havstad, Suzanne; Johnson, Christine Cole

doi:10.1111/j.1365-2222.2008.03079.x

Cited by 64 publications

(60 citation statements)

References 46 publications

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“…Infants whose mothers were administered antimicrobials during the third trimester of pregnancy had an increased risk of asthma exacerbation, whereas infants whose mothers received antimicrobials at any point during pregnancy had an increased risk of corticosteroid use and asthma-related hospitalization [39]. Studies have also considered the influences of furred pet exposure during pregnancy and show that infants had lower cord blood immunoglobulin E levels (the antibody response classically elevated in allergic disease) when their mothers resided with either cats or dogs in the home during pregnancy [40].…”

Section: Role Of the Gut Microbiome In Allergic Asthmamentioning

confidence: 98%

Influence and effect of the human microbiome in allergy and asthma

Panzer

Lynch²

2015

Current Opinion in Rheumatology

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Section: Role Of the Gut Microbiome In Allergic Asthmamentioning

confidence: 98%

Influence and effect of the human microbiome in allergy and asthma

Panzer

Lynch²

2015

Current Opinion in Rheumatology

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“…The microbiota in dust from households with dogs is significantly richer and more diverse than that found in homes without pets (93,103). This observation is interesting because exposure to pets, particularly dogs, in early life, protects against allergic sensitization and allergic disorders (104,105). Moreover dogs were domesticated between 33,000 and 11,000 y ago, so humans have coevolved with dog microbiota for many millennia (106).…”

Section: Microbiota From Animals and Other Peoplementioning

confidence: 99%

Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health

Rook

2013

Proc. Natl. Acad. Sci. U.S.A.

598

456

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Epidemiological studies suggest that living close to the natural environment is associated with long-term health benefits including reduced death rates, reduced cardiovascular disease, and reduced psychiatric problems. This is often attributed to psychological mechanisms, boosted by exercise, social interactions, and sunlight. Compared with urban environments, exposure to green spaces does indeed trigger rapid psychological, physiological, and endocrinological effects. However, there is little evidence that these rapid transient effects cause long-term health benefits or even that they are a specific property of natural environments. Meanwhile, the illnesses that are increasing in high-income countries are associated with failing immunoregulation and poorly regulated inflammatory responses, manifested as chronically raised C-reactive protein and proinflammatory cytokines. This failure of immunoregulation is partly attributable to a lack of exposure to organisms (“Old Friends”) from mankind’s evolutionary past that needed to be tolerated and therefore evolved roles in driving immunoregulatory mechanisms. Some Old Friends (such as helminths and infections picked up at birth that established carrier states) are almost eliminated from the urban environment. This increases our dependence on Old Friends derived from our mothers, other people, animals, and the environment. It is suggested that the requirement for microbial input from the environment to drive immunoregulation is a major component of the beneficial effect of green space, and a neglected ecosystem service that is essential for our well-being. This insight will allow green spaces to be designed to optimize health benefits and will provide impetus from health systems for the preservation of ecosystem biodiversity.

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“…The most convincing evidence in humans comes from studies showing that offspring born to mothers living in farming environments (a marker for high maternal microbial exposure during gestation) are protected from the development of asthma (19) and have an up-regulation of receptors of the innate immune system (20). Human offspring of mothers exposed to pets during pregnancy have lower cord blood IgE levels at birth (21), which may be protective against the development of allergic disease. The mechanisms behind such protections are being investigated, and maternal Toll-like receptor (TLR) signaling has recently been shown to be an important participant (22).…”

Section: Gestationmentioning

confidence: 99%

The Role of Microbes in Developmental Immunologic Programming

2011

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ABSTRACT:The role of microorganisms in the gastrointestinal tract has undergone significant modification in the past few decades with new observations from clinical, epidemiologic, and basic science research. We now know that the perception of these gut microbes as pathogens or even as commensals is somewhat outdated. It is becoming increasingly clear that the gut microbiome plays an important role in a host of activities including digestion, protection from potentially pathogenic organisms, and the regulation and development of the host immune system. The complex interactions between microbes and host combined with recent clinical observations and epidemiologic trends may point to the convergence of two well-supported (though imperfect) hypotheses: the "hygiene hypothesis" and the "fetal programming hypothesis." We are beginning to understand that exposure to microbes before conception, during gestation, and in the neonatal period have profound effects on the developing immune system. Recent observations from a variety of fields help support the expansion of the "fetal programming hypothesis" to a host-microbe corollary that microbe-host interactions at critical windows influence the future immune phenotype, the maintenance of immune health, and the development of immune-mediated disease. (Pediatr Res 69: 465-472, 2011)

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Prenatal exposure to household pets influences fetal immunoglobulin E production

Cited by 64 publications

References 46 publications

Influence and effect of the human microbiome in allergy and asthma

Influence and effect of the human microbiome in allergy and asthma

Regulation of the immune system by biodiversity from the natural environment: An ecosystem service essential to health

The Role of Microbes in Developmental Immunologic Programming

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