Influence and effect of the human microbiome in allergy and asthma

Panzer, Ariane R.; Lynch, Susan V.

doi:10.1097/bor.0000000000000191

Cited by 48 publications

(38 citation statements)

References 42 publications

(42 reference statements)

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“…Both the microbial burden and diversity within the lower airways were shown to be significantly higher in suboptimally controlled asthmatic patients compared to healthy individuals (83). Proteobacteria species significantly predominated in asthmatic patients using inhaled corticosteroids and showed the strongest correlations with the degree of bronchial hyper-responsiveness (82). In addition, corticosteroid resistance in asthmatic patients was found to be related to airway microbiome diversity (84).…”

Section: The Role Of Microbiotamentioning

confidence: 84%

“…Early-life airway and gut microbiota and influencing factors such as the delivery method, feeding practices, antibiotic use and living environment were shown to be related with allergic asthma development (82). Both the microbial burden and diversity within the lower airways were shown to be significantly higher in suboptimally controlled asthmatic patients compared to healthy individuals (83).…”

Section: The Role Of Microbiotamentioning

confidence: 94%

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Allergy in severe asthma

Giacco

Bakırtaş

Bel

et al. 2016

Allergy

111

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It is well recognized that atopic sensitization is an important risk factor for asthma, both in adults and in children. However, the role of allergy in severe asthma is still under debate. The term 'Severe Asthma' encompasses a highly heterogeneous group of patients who require treatment on steps 4-5 of GINA guidelines to prevent their asthma from becoming 'uncontrolled', or whose disease remains 'uncontrolled' despite this therapy. Epidemiological studies on emergency room visits and hospital admissions for asthma suggest the important role of allergy in asthma exacerbations. In addition, allergic asthma in childhood is often associated with severe asthma in adulthood. A strong association exists between asthma exacerbations and respiratory viral infections, and interaction between viruses and allergy further increases the risk of asthma exacerbations. Furthermore, fungal allergy has been shown to play an important role in severe asthma. Other contributing factors include smoking, pollution and work-related exposures. The 'Allergy and Asthma Severity' EAACI Task Force examined the current evidence and produced this position document on the role of allergy in severe asthma.

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Section: The Role Of Microbiotamentioning

confidence: 84%

Section: The Role Of Microbiotamentioning

confidence: 94%

Allergy in severe asthma

Giacco

Bakırtaş

Bel

et al. 2016

Allergy

111

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“…However, the relationship between the composition of the gut microbiome and host organism is mutual and many recent studies have focused on this unique interaction. To date, a myriad of papers have reported the association of the activity of gut microbiome with obesity and diabetes mellitus 7,34,35 asthma and allergy [36][37][38] , aging 39,40 and even the development and function of the central nervous system 41 , autism and depression 42 .…”

Section: Factors Influencing the Composition And Function Of The Micrmentioning

confidence: 99%

Human gut microbiota plays a role in the metabolism of drugs

Jourová¹,

Anzenbacher²,

Anzenbacherová³

2016

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

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a Background and Aims. The gut microbiome, an aggregate genome of trillions of microorganisms residing in the human gastrointestinal tract, is now known to play a critical role in human health and predisposition to disease. It is also involved in the biotransformation of xenobiotics and several recent studies have shown that the gut microbiota can affect the pharmacokinetics of orally taken drugs with implications for their oral bioavailability. Methods. Review of Pubmed, Web of Science and Science Direct databases for the years 1957-2016. Results and Conclusions. Recent studies make it clear that the human gut microbiota can play a major role in the metabolism of xenobiotics and, the stability and oral bioavailability of drugs. Over the past 50 years, more than 30 drugs have been identified as a substrate for intestinal bacteria. Questions concerning the impact of the gut microbiota on drug metabolism, remain unanswered or only partially answered, namely (i) what are the molecular mechanisms and which bacterial species are involved? (ii) What is the impact of host genotype and environmental factors on the composition and function of the gut microbiota, (iii) To what extent is the composition of the intestinal microbiome stable, transmissible, and resilient to perturbation? (iv) Has past exposure to a given drug any impact on future microbial response, and, if so, for how long? Answering such questions should be an integral part of pharmaceutical research and personalised health care.

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“…The intestinal microbiota is considered to influence the airway response to an inflammatory insult, as it plays a role in the development of allergic asthma (PANZER & LYNCH, 2015). Furthermore, colonization of good bacteria in the intestinal flora of Balb/C mice during their early life was able to prevent airway inflammation in asthma by regulation the Th1/Th2 balance (QIAN et al, 2017).…”

mentioning

confidence: 99%

Mineral supplement with pre- and probiotic improves respiratory immune status in yearling racing Thoroughbred horses: preliminary results

et al. 2018

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There are evidences of intestinal flora influence on the airway immune response. However, this information is scarce with regard to horses. The present preliminary study aimed to investigate the effects of a commercial mineral supplement containing probiotics and prebiotics on the respiratory immune response of horses supplemented with them during the first months of stabling and race training. Twelve TB yearlings were examined at the breeding farm at the beginning of the study (June 2016, henceforth M0) and then reexamined one (July 2016, henceforth M1) and five (November 2016, henceforth M2) months after being stabled at a racetrack in Curitiba, Brazil. Clinical and hematological examinations, airway endoscopy, and tracheal wash (TW) cytology were performed. After the initial examination, horses were randomly divided between the treatment group (TG), which received 10 grams of the supplement daily, and the control group (CG). There was no difference between the groups in terms of clinical parameters; in the hematological examination, eosinophil count was lower in the TG in M1 as compared with M0 (P = 0.045). Pharyngeal lymphoid hyperplasia (PLH) improved in the TG during M1 as compared with M0 (P = 0.007). However, on the CG, PLH remained unchanged. Relative number of eosinophils in the TW was 86.1% higher in M1 than M0 for the CG; in the TG; however, eosinophils were absent and remained within normal limits until M2. In conclusion, this study revealed a positive influence of probiotic and prebiotic supplementation on the respiratory immune response of young TB race horses. Further investigations are recommended.

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Influence and effect of the human microbiome in allergy and asthma

Cited by 48 publications

References 42 publications

Allergy in severe asthma

Allergy in severe asthma

Human gut microbiota plays a role in the metabolism of drugs

Mineral supplement with pre- and probiotic improves respiratory immune status in yearling racing Thoroughbred horses: preliminary results

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