Prenatal diagnosis and follow‐up of 23 cases of cardiac tumors

Niewiadomska-Jarosik, Katarzyna; Stańczyk, Jerzy; Jakubowski, Lucjusz; Jarosik, Piotr; Moll, J; Zamojska, Justyna; Respondek‐Liberska, Maria

doi:10.1002/pd.2586

Cited by 35 publications

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References 37 publications

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“…In one case of single cardiac tumor, presence of additional tumor in CNS suggested suspicion of rhabdomyoma during prental life, which was confirmed later on during boy's treatment in our hospital (Diagnosis "SEGA"). In the "classic" way, according to the literaure, tuberous sclerosis complex usually reveals itself in the 1-2 year of life, in child that was earlier observed because of multiple fetal cardiac tumors 3,4 .…”

Section: Discussionmentioning

confidence: 99%

Single Fetal Cardiac Tumors and Follow-Up Based on 13 Cases from the Fetal Cardiac Referral Center in 1993-2017

Żalińska

Korabiewska

Krekora

et al. 2017

Prenatal Cardiology

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Single fetal cardiac tumors and follow-up based on 13 cases from the Fetal Cardiac Referral Center in Prenat Cardio 2017 Jan; 7(1):43-49 DOI: 10.1515/pcard-2017-0007 INTRODUCTIONFetal cardiac tumors are rare anomalies: 0,08-0,2% 1,2, while data from Polish Nationwide Register of Fetal Cardiological Problems (in polish-ORPKP), suggested higher prevalence (1,05% Single fetal cardiac tumors are some sort of enigma and for now, there is no unitary algorythm of proceeding, that is why it become the aim of our work. MATERIALThe analysis included 13 cases from our unit Fetal Cardiology Department -Referral Center in the middle of Poland, during the years 1993-2017. Study group were women at the age of 18-37 years, average gestational age during targeted echocardiography examination was 34 weeks of pregnancy. The earliest registration of cardiac tumor was in 20th week of pregnancy, and the latest was during perinatal period (40th week of pregnancy).Corresponding author : a.b.zalinska@gmail.com Submitted: 2017-11-16; accepted: 2017-11-25 Results: Ten out of 13 fetuses with single cardiac tumors (SFCT) had cardiomegaly: on average HA/CA was 0,49. The size of the tumor was different: the smallest one -6 x 6 mm, the biggest 47 x 47 mm. The way of the delivery: in 10 cases there was CS and in 3 cases natural delivery. Birth weight was from 2000-3950 g (average 2989,2 g). Cardiosurgical resection of the tumor was performed on 4 newborns: at 2nd, 4th, 8th and 16th day of life (average 7,5 day). Four neonatal deaths were registered (31%): in 1st 2nd and 11th day (before surgery) and in the 28th day after the operation.Conclusions: Single fetal cardiac tumors (SFCT) can be diagnosed at 20 weeks of pregnancy, which allows to start echocardiographic monitoring, taking into consideration the potential risk of hemodynamic progression. SFCT can be the first sign of tuberous sclerosis complex in later prenatal or postnatal life. SFCT other than rhabdomyoma can be asymptomatic in newborn, but may require an early cardiosurgical resection.

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Section: Discussionmentioning

confidence: 99%

Single Fetal Cardiac Tumors and Follow-Up Based on 13 Cases from the Fetal Cardiac Referral Center in 1993-2017

Żalińska

Korabiewska

Krekora

et al. 2017

Prenatal Cardiology

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“…El estudio electrocardiográfico post natal puede demostrar una gran variedad de trastornos de la conducción que incluyen taquicardias (ventricular, focos ectópicos atriales y supraventriculares) y bradicardias con aumento del PR y cambios inespecíficos del segmento ST, síndromes de preexitación Wolff Parkinson White y conducción atrial aberrante (4, 6,7,8). En nuestro caso solo se documentó una arritmia poco significativa en la evaluación post natal.…”

Section: El Crecimientounclassified

“…La mortalidad descrita de esta patología es variable, mostrando mejores resultados en los estudio más recientes. Los factores de riesgo más significativos de mal resultado perinatal son: el tamaño (mayor 20 mm), la presencia de arritmias o de hidrops (5, 6,8). La asociación más importante de los rabdomiomas es con esclerosis tuberosa, la cual puede ser documentada durante la gestación mediante resonancia nuclear magnética fetal (9 ), su asociación es de un 50 -70 % para nódulos únicos y de alrededor de un 90 -95 % para nódulos múltiples (6, 10).…”

Section: El Crecimientounclassified

Diagnóstico prenatal de rabdomioma fetal asociado a esclerosis tuberosa. A propósito de un caso.

López

2017

Rev. chil. obstet. ginecol.

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RESUMENLos rabdomiomas son los tumores benignos cardíacos más frecuentes encontrados en vida fetal y postnatal, asociándose frecuentemente a esclerosis tuberosa. A propósito de un caso manejado en nuestra maternidad el año 2014 se revisó la literatura existente sobre su diagnóstico, manejo, implicancias pronósticas. Se trata de una embarazada de 23 años que fue referida a las 25 semanas a nuestro servicio, el estudio ecográfico revela tres imágenes cardiacas concordantes con rabdomiomas en las paredes ventriculares y el septum. No se detectan otras anormalidades y se controla en forma seriada con ultrasonido. Se realiza a las 33 semanas resonancia nuclear magnética fetal con el objetivo de evidenciar signos de esclerosis tuberosa los cuales se evidencian en el examen y se confirman en exámenes postnatales. Se comenta el diagnóstico diferencial con otros neoplasias benignas cardiacas como teratomas, fibromas y hemangiomas. Las posibles complicaciones de los rabdomiomas dependerán de su ubicación y tamaño, produciendo alteraciones en flujo o bien menos frecuentemente arritmias. La asociación más importante de esta patología es con esclerosis tuberosa de manera que se debe realizar una cuidadosa anamnesis familiar, estudios de imágenes que deben abarcar el SNC, corazón y riñones. Finalmente en ese contexto realizar la mejor consejería a los padres. PALABRAS CLAVE: Rabdomioma, esclerosis tuberosa. ABSTRACTRhabdomyomas are the most common benign cardiac tumors found in fetal and postnatal life, frequently being associated with tuberous sclerosis. In relation to a case handled in our maternity unit in 2014, existing literature on cardiac rhabdomyomas diagnosis, management and prognostic implications, was revised. The case concerned a 25 week pregnant 23 year old patient, who was referred to our facility; ultrasound examination reveals three cardiac images consistent with rhabdomyomas in the ventricular walls and the septum. No other abnormalities are detected and the patient is monitored with a series of ultrasound. At 33 weeks a fetal magnetic resonance imaging is performed in order to show signs of tuberous sclerosis which are noted in the examination and confirmed in post natal tests. Differential diagnosis with other benign cardiac neoplasms such as teratomas, fibromas and hemangiomas is discussed. Possible complications of the rhabdomyomas will depend on its location and size, producing changes in flow or less frequent arrhythmias.

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“…Most are asymptomatic, regress over time, and do not require surgical intervention [4,5]. Rhabdomyomas have a high association with tuberous sclerosis complex (TSC), a genetic disorder defined by hamartomas found in multiple systems including the brain, skin, and heart [4,5,[7][8][9][10]. Many cardiac rhabdomyomas found in children, especially those related to TSC, have multiple foci [3,4,11].…”

Section: Introductionmentioning

confidence: 99%

Pediatric Cardiac Tumors

Linnemeier

Benneyworth

Turrentine

et al. 2015

World J Pediatr Congenit Heart Surg

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Prenatal diagnosis and follow‐up of 23 cases of cardiac tumors

Abstract: Survival is not different between neonates with single and multiple tumors and between those with and without congestive heart failure.

Cited by 35 publications

References 37 publications

Single Fetal Cardiac Tumors and Follow-Up Based on 13 Cases from the Fetal Cardiac Referral Center in 1993-2017

Single Fetal Cardiac Tumors and Follow-Up Based on 13 Cases from the Fetal Cardiac Referral Center in 1993-2017

Diagnóstico prenatal de rabdomioma fetal asociado a esclerosis tuberosa. A propósito de un caso.

Pediatric Cardiac Tumors

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