Premature ovarian insufficiency – aetiopathology, epidemiology, and diagnostic evaluation

Rudnicka, Ewa; Kruszewska, Jagoda; Klicka, Klaudia; Kowalczyk, Joanna; Grymowicz, Monika; Skórska, Jolanta; Piȩta, Wojciech; Smolarczyk, Roman

doi:10.5114/pm.2018.78550

Cited by 80 publications

(87 citation statements)

References 31 publications

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“…The common dominator characterizing patients presenting with ovarian insufficiency is that they typically are unable to ovulate normally since they present with reduced number of stimulable primordial follicles [2]. The wide pallet of factors affecting ovarian function, ranging from advanced maternal age, to genetic, iatrogenic, or environmental factors, may add another level of complexity toward efficient management [3,4].…”

Section: Introductionmentioning

confidence: 99%

Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women

Sfakianoudis¹,

Simopoulou

Grigoriadis

et al. 2020

JCM

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Intraovarian platelet-rich plasma (PRP) infusion was recently introduced in the context of addressing ovarian insufficiency. Reporting on its effectiveness prior to adopting in clinical routine practice is imperative. This study aims to provide pilot data regarding PRP application for ovarian rejuvenation. Four pilot studies were conducted on poor ovarian response (POR), premature ovarian insufficiency (POI), perimenopause, and menopause, respectively. Each pilot study reports on thirty patients, 120 participants were recruited in total. All participants provided written informed consent prior to treatment. Primary outcome measures for the POR pilot study were levels of anti-müllerian hormone (AMH), antral follicle count (AFC) and oocyte yield. For the POI, perimenopausal and menopausal pilot studies primary outcome measures were restoration of menstrual cycle, and Follicle Stimulating Hormone (FSH) levels. A significant improvement on the hormonal profile and the ovarian reserve status was noted, along with improved intracytoplasmic sperm injection (ICSI) cycle performance concerning POR participants. Menstruation recovery was observed in 18 out of 30 POI patients, along with a statistically significant improvement on levels of AMH, FSH, and AFC. Similarly, 13 out of 30 menopausal women positively responded to PRP treatment. Finally, menstruation regularity, improved hormonal levels and AFC were reported for 24 out of 30 perimenopausal women. To conclude, PRP infusion appears to convey promising results in addressing ovarian insufficiency.

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Section: Introductionmentioning

confidence: 99%

Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women

Sfakianoudis¹,

Simopoulou

Grigoriadis

et al. 2020

JCM

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“…However, prevalence varies depending on population characteristics with such factors as ethnicity. Indeed, the frequency is higher among Caucasian and African than Asian women [6]. Although the definition of POF is incomplete, the European Society of Human Reproduction and Embryology (ESHRE) working group recommends as diagnostic criteria [4]: Oligo/amenorrhea for at least 4 months and FSH > 25 IU/L at twice 4 months apart.…”

Section: Introductionmentioning

confidence: 99%

“…Climacteric symptoms are less common in patients with primary amenorrhea, suggesting that they are mainly due to a cessation of estrogen excretion rather than estrogen deficiency [6].…”

Section: Introductionmentioning

confidence: 99%

“…These patients have also an increased risk of developing Table 1 Summary of long-term consequences of premature ovarian failure, according to [7] cardiovascular diseases [8] and an increased risk of allcause mortality. This pathology has also an undeniable negative impact on the psychological well-being of patients [6,9]. In a large majority of cases the aetiology of this pathology remains unexplained [10].…”

Section: Introductionmentioning

confidence: 99%

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Telomere length in granulosa cells and leukocytes: a potential marker of female fertility? A systematic review of the literature

Fattet¹,

Toupance

Thornton

et al. 2020

J Ovarian Res

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In the context of a continuously increased delay of motherhood and of an increase of the incidence of premature ovarian failure, it is of the greatest interest to dispose of a predictive marker of the duration of the fertility window. Unfortunately, current available markers of women's fertility (hormonal rates or echography count of small follicles) have a poor predictive value of premature ovarian failure. In the last ten years, some studies have suggested that telomere length may be correlated with premature ovarian failure, but the results of these studies are contradictory. In accordance with guidelines from Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), this systematic review of the literature selected studies evaluating telomere length or telomerase activity in granulosa cells and/or in leukocytes as a premature ovarian failure marker. Five publications (252 premature ovarian failure patients) were included in this review of experimental evidence. Two of them studied telomere length and/or telomerase activity in granulosa cells and 4 in leukocytes in women with premature ovarian failure. For each study, authors determined if there was a positive or a negative correlation between telomeric parameters and premature ovarian failure. 3 studies (178 premature ovarian failure patients) found shorter telomere length in granulosa cells and/or leukocytes and/or lower telomerase activity in premature ovarian failure patients. 2 studies (74 premature ovarian failure patients) presented contradictory results about the correlation of leucocyte telomere length with premature ovarian failure. Shorter telomeres and diminished telomerase activity in granulosa cells appear to be associated with ovarian insufficiency. However, the number of studies and of subjects within are low and the methodology questionable. The confirmation of these results is essential with more subjects, better defined populations and more adapted methodology, in order to consider telomere length in granulosa cells and/or in leucocytes as an early and reliable marker for the decline of ovarian function.

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“…However, the etiopathogenesis of the disease in most cases remains unexplained. Factors contributing to POI include genetic abnormalities, metabolic disorders, autoimmunity, iatrogenic causes and environmental factors amongst many others [4].…”

Section: Introductionmentioning

confidence: 99%

Clinical Profile of Women With Premature Ovarian Insufficiency Attending a Tertiary Care Center: A Cross Sectional Study

Bahadur

Mundhra

Jindal

et al. 2020

ijsr

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Introduction: Premature ovarian insufficiency (POI) is a depletion of normal ovarian function before age of 40 years accompanied by cessation of menstruation. A couple must be counseled on the effect of POI on future fertility and once diagnosed a woman needs to be evaluated annually. She requires hormone replacement therapy for bone support, cardiovascular and sexual health. Material and methods: A prospective study was conducted in department of Obstetrics and Gynecology at AIIMS Rishikesh from November 2016 to November 2018. We studied the sociodemographic profile, etiology, clinical presentation of 30 patients presenting with POI. Women less than 40 years of age with amenorrhea lasting for four months with two FSH levels in menopausal range (> 40 mIU/ml) obtained atleast one month apart were included in the study. Results: 18 (60%) women presented with amenorrhea between 1 to 2 years. 17 (56.67%) women belonged to urban region and 13 (43.33%) resided in rural area. 22 (73.3%) women had infertility of which 17 (77.27%) had primary infertility and 5 (22.72%) had secondary infertility. For the rest 8 (26.66%) women hypoestrogenic symptom, including vasomotor was the major concern. Conclusion: When POI is diagnosed in adolescent females, patient and her family are often unprepared for such news and its implications are compromised fertility and impaired self-esteem as well as long term hormonal therapy. As clinician we should be mindful of the sensitive nature of this medical condition.

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Premature ovarian insufficiency – aetiopathology, epidemiology, and diagnostic evaluation

Cited by 80 publications

References 31 publications

Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women

Reactivating Ovarian Function through Autologous Platelet-Rich Plasma Intraovarian Infusion: Pilot Data on Premature Ovarian Insufficiency, Perimenopausal, Menopausal, and Poor Responder Women

Telomere length in granulosa cells and leukocytes: a potential marker of female fertility? A systematic review of the literature

Clinical Profile of Women With Premature Ovarian Insufficiency Attending a Tertiary Care Center: A Cross Sectional Study

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