Our system is currently under heavy load due to increased usage. We're actively working on upgrades to improve performance. Thank you for your patience.

Curr Atheroscler Rep

2020

DOI: 10.1007/s11883-020-00862-8

|View full text |Cite

|

Sign up to set email alerts

|

Premature Atherosclerotic Cardiovascular Disease: What Have We Learned Recently?

¹

,

²

,

³

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Discussion3

Citation Types

Supporting

1

Mentioning

10

Contrasting

0

Year Published

2021

2021

2023

2023

Publication Types

Select...

Article7

Relationship

Self Cite2

Independent5

Authors

Journals

Cited by 25 publications

(12 citation statements)

References 136 publications

Supporting

1

Mentioning

10

Contrasting

0

Order By: Relevance

“… 29 30 Although old age is a strong risk factor, several studies have noticed that patients with a premature ASCVD history have all-cause and cardiovascular mortality similar to those of older adults. 31 32 In this study, the risk for MI, ischemic stroke, and all-cause death was not significantly different between patients with and without premature ASCVD history, consistent with previous studies. We could not completely investigate patients with premature ASCVD because we had no data prior to 2009.…”

Section: Discussionsupporting

confidence: 90%

Assessing the Validity of the Criteria for the Extreme Risk Category of Atherosclerotic Cardiovascular Disease: A Nationwide Population-Based Study

¹

,

²

,

³

et al. 2022

J Lipid Atheroscler

View full text Add to dashboard Cite

Objective To validate the criteria for the extreme risk category for atherosclerotic cardiovascular disease (ASCVD). Methods An observational cohort study of 35,464 individuals with established ASCVD was performed using the National Health Information Database. Incident myocardial infarction (MI), ischemic stroke, and death in patients with established ASCVD was investigated to validate the criteria for the extreme risk category of ASCVD defined as the presence of diabetes mellitus (DM), chronic kidney disease (CKD), and history of premature ASCVD. Results Among 35,464 patients, 77.97% of them were classified into the extreme risk group of ASCVD. A total of 28.10%, 39.61%, and 32.12% had DM, CKD, and a history of premature ASCVD, respectively. During a mean follow-up of 8.39 years, MI, ischemic stroke, and all-cause death were found in 3.87%, 8.51%, and 23.98% of participants, respectively. In multivariate analysis, patients with DM had higher risk for MI (hazard ratio [HR], 1.62; 95% confidence interval [CI], 1.45–1.81), ischemic stroke (HR, 1.39; 95% CI, 1.29–1.50), and all-cause death (HR, 1.52; 95% CI, 1.45–1.59) than those without DM. Patients with CKD had 1.56 times higher risk for MI, 1.12 times higher risk for ischemic stroke, and 1.34 times higher risk for death than those without CKD. However, the risk for MI, ischemic stroke, and all-cause death was not different between patients with and without a history of premature ASCVD. Conclusion DM and CKD, but not a history of premature ASCVD, could be considered as reasonable criteria of an extreme risk for ASCVD.

“… 29 30 Although old age is a strong risk factor, several studies have noticed that patients with a premature ASCVD history have all-cause and cardiovascular mortality similar to those of older adults. 31 32 In this study, the risk for MI, ischemic stroke, and all-cause death was not significantly different between patients with and without premature ASCVD history, consistent with previous studies. We could not completely investigate patients with premature ASCVD because we had no data prior to 2009.…”

Section: Discussionsupporting

confidence: 90%

Assessing the Validity of the Criteria for the Extreme Risk Category of Atherosclerotic Cardiovascular Disease: A Nationwide Population-Based Study

¹

,

²

,

³

et al. 2022

J Lipid Atheroscler

View full text Add to dashboard Cite

Objective To validate the criteria for the extreme risk category for atherosclerotic cardiovascular disease (ASCVD). Methods An observational cohort study of 35,464 individuals with established ASCVD was performed using the National Health Information Database. Incident myocardial infarction (MI), ischemic stroke, and death in patients with established ASCVD was investigated to validate the criteria for the extreme risk category of ASCVD defined as the presence of diabetes mellitus (DM), chronic kidney disease (CKD), and history of premature ASCVD. Results Among 35,464 patients, 77.97% of them were classified into the extreme risk group of ASCVD. A total of 28.10%, 39.61%, and 32.12% had DM, CKD, and a history of premature ASCVD, respectively. During a mean follow-up of 8.39 years, MI, ischemic stroke, and all-cause death were found in 3.87%, 8.51%, and 23.98% of participants, respectively. In multivariate analysis, patients with DM had higher risk for MI (hazard ratio [HR], 1.62; 95% confidence interval [CI], 1.45–1.81), ischemic stroke (HR, 1.39; 95% CI, 1.29–1.50), and all-cause death (HR, 1.52; 95% CI, 1.45–1.59) than those without DM. Patients with CKD had 1.56 times higher risk for MI, 1.12 times higher risk for ischemic stroke, and 1.34 times higher risk for death than those without CKD. However, the risk for MI, ischemic stroke, and all-cause death was not different between patients with and without a history of premature ASCVD. Conclusion DM and CKD, but not a history of premature ASCVD, could be considered as reasonable criteria of an extreme risk for ASCVD.

“…This situation could lead them to premature ACS [2]. In addition to these traditional risk factors, nontraditional risk factors (e.g., human immunodeficiency virus, inflammatory diseases, recreational drug use, and psychosocial stress) are associated with premature atherosclerotic events [19]. Chronic stress is associated with a considerable risk for CHD incidence, supporting the notion that stress is a causal CHD risk factor.…”

Section: Discussionmentioning

confidence: 99%

Association between obesity grade and the age of the first acute coronary syndrome: Prospective observational study

¹

,

²

,

³

2022

International Journal of Cardiology

View full text Add to dashboard Cite

No abstract

“…Established risk factors of ASCVDs include age, the male sex, family history of ASCVDs, obesity, hypertension, hypercholesteremia, and diabetes ( 18 , 19 ). However, recent studies also demonstrated that some patients without these risk factors may still develop ASCVDs, thus highlighting the importance of identifying novel risk factors for ASCVDs in the general population ( 20 – 22 ). TyG index has been identified as an indicator of cardiovascular events in Asia or Europe ( 10 , 23 ), however, whether TyG index could be a hallmark of CVD incidence in the United States remains unclear because of the differences in the genes of CVD susceptibility and risk factors ( 24 , 25 ).…”

Section: Discussionmentioning

confidence: 99%

Triglyceride-glucose index and estimated 10-year risk of a first hard cardiovascular event

¹

,

²

,

³

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

BackgroundWhether Triglyceride-glucose (TyG) index is associated with 10-year risk of a first hard atherosclerotic cardiovascular disease (ASCVD) event in the United States remains unclear.MethodsIn this cross-sectional study, the participants, ranged from 40 to 79 years old, were from the National Health and Nutrition Examination Survey (NHANES) between 1999 and 2018. TyG index was the independent variable and 10-year risk of a first hard ASCVD was the dependent variable. The other variables, such as age, gender, race, body mass index (BMI), hypertension treatment states, smoking states and low-density lipoprotein cholesterol (LDL-C) et al. were considered as the potential confounding factors. Multivariate linear regression models and smooth curve fittings were used to evaluate the association between TyG index and 10-year risk of a first hard ASCVD event.ResultsA total of 2,142 participants were included in the analysis. The results showed that TyG index was associated with an increased 10-year risk of a first hard ASCVD event [β = 2.208, 95% (1.716, 2.700), P < 0.00001]. The association had statistical significance in both men [β = 3.862 95% CI (3.274, 4.450), P < 0.00001] and women [β = 1.067, 95% CI (0.286, 1.849), P = 0.00756)] according to subgroup analysis. Smooth curve fittings revealed that TyG index was linearly associated with 10-year risk of ASCVD in both male and female.ConclusionTriglyceride-glucose index was associated with an increased 10-year risk of a first hard ASCVD event in the United States, suggesting it is necessary to monitor and control an appropriate range of TyG index.

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Product

Browser Extension Assistant by scite Citation Statement Search Reference Check Visualizations Dashboards Explore Journals Explore Organizations Explore Funders Embedding Badge Embedding Citation Search Pricing

Resources

Blog Help & FAQ Accessibility Statement API Terms For Universities & Governments For Researchers For Publishers For Corporate, Pharma & Enterprise Author Marketing Become an Affiliate Get an organization trial or quote scite Data & Services

About

News & Press Careers Read our Paper Coverage

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Copyright © 2024 scite LLC. All rights reserved.

Made with 💙 for researchers

Part of the Research Solutions Family.