Triglyceride-glucose index and estimated 10-year risk of a first hard cardiovascular event

Qu, Hua; Long, Linzi; Chen, Li; Wu, Han-tao; Fu, Changgeng; Zhang, Shanshan

doi:10.3389/fcvm.2022.994329

Cited by 6 publications

(6 citation statements)

References 29 publications

(29 reference statements)

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“…For instance, a research conducted in the U.S showed that the relationship between TyG and 10-year risk of ASCVD was stronger in men than women. [37] while the correlation was found to be higher in women than men in another study, in line with our current ndings. [18] Therefore, further exploration is essential for deeper explanation of the gender difference.…”

Section: Discussionsupporting

confidence: 92%

Association of triglyceride-glucose index and its related parameters with atherosclerotic cardiovascular disease: evidence from a 15-year follow-up of Kailuan cohort

Xia,

Chen,

Tian

et al. 2024

Preprint

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Background Triglyceride glucose (TyG) index and its related parameters has been introduced as cost-effective surrogate indicators of insulin resistance, while prospective evidence on their effects on risk of atherosclerotic cardiovascular disease (ASCVD) remained scattered and inconsistent. We aimed to evaluate the association of TyG with new-onset ASCVD and further compare their predictive capacity. Method A total of 95,342 ASCVD-free participants were enrolled from the Kailuan study. TyG and its related parameters were defined by fasting blood glucose, triglyceride, BMI, WC and WHtR. The primary outcome was incident ASCVD, comprising myocardial infarction (MI) and ischemic stroke (IS). Cox proportional hazard models and restricted cubic spline analyses were adopted to investigate the association between each index and ASCVD. The C-index, integrated discrimination improvement (IDI), and net reclassification improvement (NRI) were used for comparison of their predictive value for ASCVD. Results During a median follow-up of 15.0 years, 8,031 new cases of ASCVD were identified. The incidence rate of ASCVD increased along with elevated levels of each index, and the relationships were found to be nonlinear in the RCS analyses. The hazard ratio (HR) and 95% confidence interval (95% CI) for ASCVD was 1.39 (1.35, 1.43), 1.46 (1.41, 1.50), 1.50 (1.46, 1.55), and 1.52 (1.48, 1.57) per 1 IQR increase of baseline TyG, TyG-BMI, TyG-WC, and TyG-WHtR, respectively, and the association were more pronounced for females and younger individuals aged <60 years (P for interaction<0.05). Using the updated mean or time-varying measurements instead of baseline indicators did not significantly alter the primary findings. Additionally, TyG-WC and TyG-WHtR showed better performance in predicting risk of ASCVD than TyG, with the IDI (95% CI) of (0.001, 0.004) and 0.004 (0.001, 0.004) and the category-free NRI (95% CI) of 0.120 (0.025, 0.138) and 0.143 (0.032, 0.166), respectively. Similar findings were observed for MI and IS. Conclusions Both the TyG index and its related parameters were significantly and positively associated with ASCVD. TyG-WC and TyG-WHtR had better performance in predicting incident ASCVD than TyG, which might be more suitable indices for risk stratification and enhance the primary prevention of ASCVD.

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Section: Discussionsupporting

confidence: 92%

Association of triglyceride-glucose index and its related parameters with atherosclerotic cardiovascular disease: evidence from a 15-year follow-up of Kailuan cohort

Xia,

Chen,

Tian

et al. 2024

Preprint

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“…Our research demonstrates a signifcant and positive connection between TyG and total CVD, congestive heart failure, myocardial infarction, angina pectoris, and coronary heart disease in the United States population, consistent with previous studies [ 33 , 34 ]. However, current research on TyG and cardiovascular disease has centered on European and Asian populations, with a limited number of studies conducted in the United States [ 35 ]. Following the adjustment of nutritional data covariates such as total energy intake, AHEI, and dietary supplements, our investigation determined that TyG showed a significant and affirmative correlation with total CVD, congestive heart failure, myocardial infarction, angina pectoris, and coronary heart disease.…”

Section: Discussionmentioning

confidence: 99%

“…A joint study of a prospective cohort and the Hong Kong Cohort Study showed that the association between the TyG index and the risk of heart failure events was stronger in women than in men [ 45 ]. In another study of the TyG index and the risk of a first major hard cardiovascular event within ten years, subgroup analyses showed that the above correlation was [β = 3.862 95% CI (3.274, 4.450), < 0.00001] in men and [β = 1.067, 95% CI (0.286, 1.849), = 0.00756] in women) [ 35 ]. Futhermore, our study suggests that associations between TyG, TyG-WC, TyG-WHtR, and TyG-BMI and CVD and CVD mortality was higher in no diabetes.…”

Section: Discussionmentioning

confidence: 99%

The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease: NHANES 2003–2018

Dang,

Wang,

et al. 2024

Cardiovasc Diabetol

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Background In the American population, the relationship between the triglyceride-glucose (TyG) index and TYG combined with indicators of obesity and cardiovascular disease (CVD) and its mortality has been less well studied. Methods This cross-sectional study included 11,937 adults from the National Health and Nutrition Examination Survey (NHANES) 2003–2018. Cox proportional hazards model, binary logistic regression analyses, restricted cubic spline (RCS), and receiver operating characteristic (ROC) were used to analyze the relationship between TyG and its combined obesity-related indicators and CVD and its mortality. Mediation analysis explored the mediating role of glycated hemoglobin and insulin in the above relationships. Results In this study, except for no significant association between TyG and CVD mortality, TyG, TyG-WC, TyG-WHtR, and TyG-BMI were significantly and positively associated with CVD and CVD mortality. TyG-WHtR is the strongest predictor of CVD mortality (HR 1.66, 95% CI 1.21–2.29). The TyG index correlated better with the risk of coronary heart disease (OR 2.52, 95% CI 1.66–3.83). TyG-WC correlated best with total CVD (OR 2.37, 95% CI 1.77–3.17), congestive heart failure (OR 2.14, 95% CI 1.31–3.51), and angina pectoris (OR 2.38, 95% CI 1.43–3.97). TyG-WHtR correlated best with myocardial infarction (OR 2.24, 95% CI 1.45–3.44). RCS analyses showed that most of the above relationships were linear (P-overall < 0.0001, P-nonlinear > 0.05). Otherwise, ROC curves showed that TyG-WHtR and TyG-WC had more robust diagnostic efficacy than TyG. In mediation analyses, glycated hemoglobin mediated in all the above relationships and insulin-mediated in partial relationships. Conclusions TyG-WC and TyG-WtHR enhance CVD mortality prediction, diagnostic efficacy of CVD and its mortality, and correlation with some CVD over and above the current hottest TyG. TyG-WC and TyG-WtHR are expected to become more effective metrics for identifying populations at early risk of cardiovascular disease and improve risk stratification.

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“…Hua et al. simulated the incidence of ASCVD in participants over the next 10 years and found that the TyG index was associated with an increased risk of ASCVD ( 27 ). Previous studies have demonstrated the promising potential of the TyG index in predicting the risk of CAD ( 28 , 29 ) and the prognosis of adverse cardiovascular events in patients with acute coronary syndrome (ACS) ( 30 , 31 ), stable CAD ( 32 , 33 ), or non-obstructive CAD ( 34 ).…”

Section: Discussionmentioning

confidence: 99%

Association between the triglyceride glucose index and atherosclerotic cardiovascular disease in the general population: analysis of the national health and nutrition examination survey 1999–2004

Jihong,

Xiaojie,

et al. 2024

Front. Endocrinol.

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ObjectiveThe triglyceride-glucose (TyG) index, a reliable substitute indicator of insulin resistance (IR), is considered an independent risk factor for long-term outcomes in patients with cardiovascular disease. However, studies investigating the association between TyG and atherosclerotic cardiovascular disease (ASCVD) are limited and lack direct evidence. We aim to examine the relationship between the TyG index and ASCVD through a comprehensive cross-sectional study.MethodsOverall, 7212 participants from the 1999–2004 National Health and Nutrition Examination Survey were included. The baseline TyG index was calculated as ln [fasting triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2]. Restricted cubic spline (RCS) regression, univariate logistic regression, and multivariate logistic regression analysis were used to evaluate the association between the TyG index and ASCVD.ResultsIn the overall population, a multivariate logistic regression analysis showed that the TyG level was not only positively associated with ASCVD [OR (95%CI): 1.29 (1.01,1.64), P=0.042], coronary artery disease (CAD) [OR (95%CI): 1.82(1.33,2.48), P<0.001], and stroke [OR (95%CI): 2.68(1.54,4.69), P=0.002], but also linearly correlated with all three (P-overall<0.001; P-non-linear >0.05). Although the TyG index was not associated with peripheral arterial disease (PAD) [OR (95%CI): 1.00 (0.73,1.36), P>0.900], it showed a U-shaped correlation with PAD (P-overall <0.001; P-non-linear= 0.0085), and the risk of PAD was minimized when TyG=8.67. By incorporating the TyG index into the baseline risk model, the accuracy of ASCVD prediction was improved [AUC: baseline risk model, 0.7183 vs. baseline risk model + TyG index, 0.7203, P for comparison=0.034]. The results of the subgroup analysis were consistent with those of the main analysis.ConclusionThe TyG index was independently associated with ASCVD, CAD, and stroke, suggesting that it may serve as a valid indicator for predicting ASCVD in the entire population.

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Triglyceride-glucose index and estimated 10-year risk of a first hard cardiovascular event

Cited by 6 publications

References 29 publications

Association of triglyceride-glucose index and its related parameters with atherosclerotic cardiovascular disease: evidence from a 15-year follow-up of Kailuan cohort

Association of triglyceride-glucose index and its related parameters with atherosclerotic cardiovascular disease: evidence from a 15-year follow-up of Kailuan cohort

The association between triglyceride-glucose index and its combination with obesity indicators and cardiovascular disease: NHANES 2003–2018

Association between the triglyceride glucose index and atherosclerotic cardiovascular disease in the general population: analysis of the national health and nutrition examination survey 1999–2004

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