Association between obesity grade and the age of the first acute coronary syndrome: Prospective observational study

Demirci, Deniz; Demirci, Duygu Ersan; Chi, Gerald

doi:10.1016/j.ijcard.2021.11.080

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…However, the multivariable logistic regression showed that BMI was an independent predictor of ischemia in our patient cohort. Our results are in accordance with a previous study by Demirci et al [ 35 ], that evaluated the role of obesity (overweight, grade I obesity, and severe obesity) in 1005 patients who had a first episode of acute coronary syndrome. These authors reported that compared to normal weight patients, the first coronary episode occurred 3.9 years earlier in overweight patients, 6.1 years earlier in patients with grade I obesity, and 7.7 years earlier in patients with severe obesity.…”

Section: Discussionsupporting

confidence: 93%

Body Mass Index Is Independently Associated with the Presence of Ischemia in Myocardial Perfusion Imaging

et al. 2022

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Background and Objectives: Obesity has been linked to various cardiovascular risk factors, increased incidence of coronary artery disease, and myocardial perfusion defects. The aim of this study was to investigate if body mass index (BMI) and waist circumference (WC) were associated with myocardial perfusion defects. Materials and Methods: A total of 308 consecutive patients who had myocardial perfusion imaging (MPI) with single photon emission computed tomography (SPECT) and a complete medical record on file were studied retrospectively. Results: The median age was 69 (61–76) years, the BMI was 27.6 (24.4–30.7) kg/m2, and the WC was 110 (102–118) cm. Of the 308 patients, 239 patients (77.6%) had myocardial ischemia. A positive test for ischemia was more frequent in men compared to women (72 vs. 28%, p < 0.001). Within the male group, BMI and WC were not significantly different between the ischemia and non-ischemia groups. In contrast, within the female group, both BMI (30.2 vs. 27.1 kg/m2, p = 0.002) and WC (112 vs. 105.5 cm, p = 0.020) were significantly higher in the ischemia group. Multivariable logistic regression showed that male sex and BMI were the only two independent predictors of ischemia in our patient population. Conclusions: This study showed that BMI was an independent predictor of ischemia in our patient population.

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Section: Discussionsupporting

confidence: 93%

Body Mass Index Is Independently Associated with the Presence of Ischemia in Myocardial Perfusion Imaging

et al. 2022

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“…Obesity is linked to an March 2024 | Vol 5 | Article 3 increased risk of ACS across various lifestyle behavior subgroups, including both healthy and less healthy ones. It's interesting to note that some research suggests a connection between obesity and a lower risk of mortality following ACS when compared to individuals with normal weight, a phenomenon referred to as the "obesity paradox" [30] . It's important to note that other studies have found that more severe levels of obesity are linked to an earlier onset of ACS.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Impact of Modifiable Risk Factors on Acute Coronary Syndrome: A Case Control Study

Kusuma,

I Gede Bagus Gita Pranata Putra

2024

CCJ

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Highlights: 1. Smoking duration, dyslipidemia, hypertension, diabetes mellitus, obesity, and hyperuricemia, are significantly associated with ACS. 2. Obesity and hypertension are identified as risk factors for inpatient ACS. - Background: Acute coronary syndrome (ACS) is defined by the abrupt reduction or total obstruction of blood flow to the myocardium. Recognized risk factors for ACS include conditions such as hypertension, dyslipidemia, smoking, obesity, diabetes mellitus, hyperuricemia, as well as variables like age, gender, and family history of the ailment. The objective of this research was to examine the prevalence and importance of modifiable risk factors associated with ACS. Material and Methods: The study is structured as a prospective case-control study. The research sample comprises 100 ACS patients, categorized into three groups: STEMI, NSTEMI, and UAP. The Chi-Square test and logistic regression were used to examine the samples. The threshold for statistical significance was set at p<0.05. Results: ACS occurred more frequently in male patients (54%) and those aged ≥ 40 years (85%). Several factors demonstrated significant associations with ACS, including smoking habits, dyslipidemia, hypertension, diabetes mellitus, obesity, and hyperuricemia. Among these, inpatient ACS was notably linked with obesity (OR: 7.42; 95% CI: 1.48-37.11; p=0.015) and hypertension (OR: 0.13; 95% CI: 0.03-0.53; p=0.005). The presence of ACS was also correlated with a notable increase in inpatient care, with obesity and hypertension emerging as risk factors for inpatient ACS. Conclusion: ACS was more common in males and individuals aged 40 or older, with significant associations identified between ACS and various factors, including smoking, dyslipidemia, diabetes, obesity, hyperuricemia, and hypertension, with obesity and hypertension specifically linked to inpatient ACS.

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“…Elderly subjects, due to the impact of aging, are at increased risk of developing “android”, abdominal obesity and associated metabolic syndrome. Abdominal adiposity [ 2 ] has been associated with a high risk of cardiovascular events [ 3 ]. Early studies focused on the waist-to-hip circumference (WHC) ratio as a key measure.…”

Section: Introductionmentioning

confidence: 99%

Obesity related to metabolic syndrome: comparison of obesity indicators in an older french population

Assoumou

Pichot

Barthélémy

et al. 2023

Diabetol Metab Syndr

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Objectives Metabolic syndrome (MS) represents a cluster of metabolic abnormalities. Insulin resistance is a major component of the syndrome. We analyze in this study the relationship between body fat composition and MS in comparison to usual obesity indicators in an older adult population. Design : The PROgnostic indicator OF cardiovascular and cerebrovascular events (PROOF) study is a prospective longitudinal community cohort study among the inhabitants of Saint-Etienne, France. Methods The study is a cohort study of 1011 subjects, mean age 65.6 ± 0.8 years old at inclusion, recruited from the electoral list of the town in 2000. Among them, 806 subjects realized a Dual-energy X-ray absorptiometry (DXA) used to evaluate body fat and lean mass repartition. We evaluate biological metabolic parameters according to usual techniques. The indices of obesity were calculated according to standard formula. MS presence and its components were simultaneously evaluated. Results All obesity parameters were significantly higher (p < 0.0001) in subjects suffering metabolic syndrome as compared to those without. Body fat index (BFI) presented a stronger correlation to total fat mass, trunk fat mass and body adiposity index (BAI). The correlations between body indices and metabolic components showed that body mass index (BMI) and waist circumference were more strongly associated with BFI as compared to BAI and total fat mass. According to logistic regression analysis, only the waist-hip ratio (WHR) demonstrated a significant association with MS severity (p < 0.0001). Conclusions Among the obesity indices, BFI and BAI represented the best indicators to characterize global obesity while WHR only is highly predictive of metabolic syndrome presence and severity. The BAI indicator is an alternative for measuring obesity. Comparison of long-term impact of such markers on cardiovascular morbidity and mortality is now questioned.

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Association between obesity grade and the age of the first acute coronary syndrome: Prospective observational study

Cited by 4 publications

References 35 publications

Body Mass Index Is Independently Associated with the Presence of Ischemia in Myocardial Perfusion Imaging

Body Mass Index Is Independently Associated with the Presence of Ischemia in Myocardial Perfusion Imaging

Prevalence and Impact of Modifiable Risk Factors on Acute Coronary Syndrome: A Case Control Study

Obesity related to metabolic syndrome: comparison of obesity indicators in an older french population

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