Preliminary phytochemical screening and evaluation of hypoglycemic properties of the root extract of <i>Uveria chamae</i>

Abstract

Research ArticlePreliminary phytochemical screenPreliminary phytochemical screenPreliminary phytochemical screening and evaluation of hypoglycemic ing and evaluation of hypoglycemic ing and evaluation of hypoglycemic properties of the root extract of properties of the root extract of properties of the root extract of Uvaria chamae Uvaria chamae Uvaria chamae BJP IntroductionDiabetes mellitus has been described as a metabolic disorder of multiple etiologies characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action or both (Walter, 1977;Albert et al., 1998;Kumar and Clark, 2005).It is a major degenerative disease in the world today afflicting many lives both in the developed and developing countries (Mbaka et al., 2012). It is usually irreversible and its late complications result in reduced life expectancy and major health loss (Kumar and Clark, 2005). Currently diabetes is controlled by diet, exercise, oral hypoglycaemic agents and insulin therapy (Mallick et al., 2007). The high level of treatment failures, unpleasant side effects and enormous cost associated with oral anti-diabetic drugs have generated an urgent need and desire for alternative treatments (Suneetha et al., 2010). The preferred choice of plant medicine by many might not be unconnected with the historical successes recorded in the use of herbal product in traditional system of medicine in managing diabetes mellitus (Mbaka et al., 2012). Besides, herbal formulations were observed to have fewer side effects and less toxic because of their rich natural source. Based on these and the support provided for its practice by the World Health Organization, several scientific investigations are being conducted with the view of identifying new active ingredient of natural source that would be more effective in the treatment of diabetes mellitus and diabetic complications (WHO, 1980). Uvaria chamae is a medicinal plant that belongs to the family, Annonaceae. It is a climbing plant commonly found in West Africa (Irvin, 1961;Okwu, 2004 AbstractThe purpose of this study is to evaluate the hypoglycaemic properties and preliminary phytochemical screening of Uvaria chamae. The hypoglycaemic properties of U. chamae was assessed on normoglycaemic rat that received single dose of the extract at 250 and 500 mg/kg body weight and blood glucose levels estimated at 2, 4, and 6 hours (single dose study). The hypoglycaemic property of the extract was also evaluated in normoglycemic rats by oral glucose tolerance test. Phytochemical screening of the extract for the presence of secondary metabolites was performed with standard methods. The extract showed a significant (p<0.05) reduction in blood glucose levels at 2 and 6 hours compared to control. The oral glucose tolerance test result also showed a significant decrease (p<0.05) in blood glucose levels. The study showed that the extract, U. chamae has hypoglycaemic properties which may be accounted for by the presence of t...

Antidiabetic and hypolipidemic activities of hydroethanolic root extract of Uvaria chamae in streptozotocin induced diabetic albino rats

“…The high level of treatment failures, unpleasant side effects and enormous cost associated with diabetic therapy have generated an urgent need and desire for alternative treatments [8]. However, the preferred choice of plant medicine by many might not be unconnected with the historical successes recorded in the use of herbal products in traditional system of medicine in the management of diabetes mellitus [9]. One of such plants used traditionally in the management of diabetes mellitus is Uvaria chamae .…”

Anti-oxidant, antimicrobial and anti-acetylcholinesterase activities of organic extracts from aerial parts of three Tunisian plants and correlation with polyphenols and flavonoids contents

“…The high correlation between flavonoids content and anti-radical capacity is due to hydroxyl groups in flavonoids molecules that confer scavenging ability on them (Emeka et al, 2015). As regard β-carotene bleaching system, linoleic acid produces hydroperoxides as free radicals during incubation at 50°C .…”

Taxithelium napalense acts against free radicals and diabetes mellitus

“…As earlier mentioned, the demand for identification of new drugs from natural products gaining day by day (Mohan et al, 2014;Emeka et al, 2015;Rehman et al, 2015;Ganesan et al, 2016), current research was carried on moss, T. napalense and it is initial reports on phytochemical analysis, antioxidant capacity and antidiabetic capacity. There were some earlier reports on different biological activities on bryophytes including mosses (Laura et al, 2015;Vizma et al, 2012) but there was no reports on T. napalense.…”

“…The demand on natural antidiabetic preparations/ products is gaining interest due to undesirable side effects, toxicity and high cost of synthetic drugs (oral hypoglycemic drugs) and insulin (Mohan et al, 2014;Emeka et al, 2015;Rehman et al, 2015;Ganesan et al, 2016).…”