Preliminary phytochemical and preclinical toxicity studies of Grewia serrulata DC

Chandiran, Irisappan Sarath; Jayaveera, Κ. N.; Karimulla, Shaik

doi:10.1016/j.dit.2013.06.010

Cited by 7 publications

(2 citation statements)

References 5 publications

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“…Once daily clinical observation was made following the administration of control, blank formulation, standard drug, and nanoformulation to detect sign of toxicity like general behavior, motor activities, reflexes, and changes in skin and fur texture. Body weight of animal was recorded once a week [ 13 ].…”

Section: Methodsmentioning

confidence: 99%

Subacute Toxicity Profile of Lacidipine Nanoformulation in Wistar Rats

Shirodkar

Misra

et al. 2015

The Scientific World Journal

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The present study was aimed at investigating the safety of Lacidipine (LCDP) loaded nanostructured lipid carriers (NLCs) in Wistar rats. NLCs were formulated using ultrasound dispersion technique. Animals were orally treated once daily with NLCs containing 0.140 mg, 0.350 mg, and 0.875 mg of LCDP as low, medium, and high dose per kg body weight, respectively, during 28 days along with blank formulation and pure LCDP. Control rats were fed with water. Animals were observed throughout experiment period and their body weight was recorded once weekly. Overnight fasted rats were sacrificed on the 29th day. Study revealed no signs or symptoms of toxicity or morbidity. No significant changes in the body weight were observed between treated and control group. Significant increase in left testis weight and liver weight was observed in male and female rats, respectively. Haematological estimation revealed significant decrease in haemoglobin count in male rats while female rats showed significant increase in granulocyte count. All the serum clinical parameters were within the normal range and no gross histopathological changes were observed. No delayed effect was noted in satellite group. The results indicate that developed LCDP loaded NLCs are safe when administered orally in rats.

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Section: Methodsmentioning

confidence: 99%

Subacute Toxicity Profile of Lacidipine Nanoformulation in Wistar Rats

Shirodkar

Misra

et al. 2015

The Scientific World Journal

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“…Among various Ficus tsiela leaf extracts, diethyl ether extract showed the best inhibitory effect on Klebsiella pneumoniae , Escherichia coli , and Pseudomonas aeruginosa . Finally, a decrease in activity against Staphylococcus aureus was observed ( 177 ).…”

Section: Beneficial Health Effects Of Popular and Exotic Fruit Plant ...mentioning

confidence: 99%

From by-products to new application opportunities: the enhancement of the leaves deriving from the fruit plants for new potential healthy products

Regolo,

Giampieri,

Battino

et al. 2024

Front. Nutr.

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In the last decades, the world population and demand for any kind of product have grown exponentially. The rhythm of production to satisfy the request of the population has become unsustainable and the concept of the linear economy, introduced after the Industrial Revolution, has been replaced by a new economic approach, the circular economy. In this new economic model, the concept of “the end of life” is substituted by the concept of restoration, providing a new life to many industrial wastes. Leaves are a by-product of several agricultural cultivations. In recent years, the scientific interest regarding leaf biochemical composition grew, recording that plant leaves may be considered an alternative source of bioactive substances. Plant leaves’ main bioactive compounds are similar to those in fruits, i.e., phenolic acids and esters, flavonols, anthocyanins, and procyanidins. Bioactive compounds can positively influence human health; in fact, it is no coincidence that the leaves were used by our ancestors as a natural remedy for various pathological conditions. Therefore, leaves can be exploited to manufacture many products in food (e.g., being incorporated in food formulations as natural antioxidants, or used to create edible coatings or films for food packaging), cosmetic and pharmaceutical industries (e.g., promising ingredients in anti-aging cosmetics such as oils, serums, dermatological creams, bath gels, and other products). This review focuses on the leaves’ main bioactive compounds and their beneficial health effects, indicating their applications until today to enhance them as a harvesting by-product and highlight their possible reuse for new potential healthy products.

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Fruits of Indian Subcontinent and Their Health Benefits

Sidhu

Zafar

2019

Herbal Medicine in India

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Preliminary phytochemical and preclinical toxicity studies of Grewia serrulata DC

Cited by 7 publications

References 5 publications

Subacute Toxicity Profile of Lacidipine Nanoformulation in Wistar Rats

Subacute Toxicity Profile of Lacidipine Nanoformulation in Wistar Rats

From by-products to new application opportunities: the enhancement of the leaves deriving from the fruit plants for new potential healthy products

Fruits of Indian Subcontinent and Their Health Benefits

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