Preliminary Investigations of the Anti-asthmatic Properties of the Aqueous Extract of Justicia pectoralis (Fresh cut)

Cameron, Ch; Jacob, AS; Thomas, Everton A; Levy, Arkene

doi:10.7727/wimj.2014.149

Cited by 9 publications

(11 citation statements)

References 18 publications

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“…Named popularly as ‘chambá’ in the Brazilian north‐east, this species is useful as expectorant and is in the list of plants potentially useful for phytotherapy purposes according to the Brazilian Health Surveillance Agency (Anvisa) . A few studies reinforce the notion that J. pectoralis can be effective in the respiratory system, and a recent preliminary study revealed potential antiasthmatic properties of an aqueous extract obtained from J. pectoralis by its ability to inhibit histamine‐induced contraction on guinea‐pig trachea …”

Section: Introductionmentioning

confidence: 73%

“…Although the hyper‐responsive phenotype remained observable in OVA‐challenged tracheal tissues maintained in the continuous presence of the extract of J. pectoralis , hyper‐responsiveness was evident only at higher Ca 2+ concentrations in preparations stimulated with ACh or KCl, findings that indicate antispasmodic actions for the extract. Cameron et al . recently reported inhibitory properties of a crude extract of J. pectoralis on guinea‐pig tracheal contractility.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Inhibitory effects of a standardized extract ofJusticia pectoralisin an experimental rat model of airway hyper-responsiveness

Moura

Batista‐Lima

Brito

et al. 2017

Journal of Pharmacy and Pharmacology

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Section: Introductionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of a standardized extract ofJusticia pectoralisin an experimental rat model of airway hyper-responsiveness

Moura

Batista‐Lima

Brito

et al. 2017

Journal of Pharmacy and Pharmacology

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“…The extract blocked the effect of contraction produced by histamine in the airways [46]. The standardized extract of coumarin from the aerial parts' hydroalcoholic extract of this plant was also tested to evaluate the antiasthmatic properties in male rats previously sensitized by OVA.…”

Section: Resultsmentioning

confidence: 99%

Organic Extract of Justicia pectoralis Jacq. Leaf Inhibits Interferon‐γ Secretion and Has Bacteriostatic Activity against Acinetobacter baumannii and Klebsiella pneumoniae

Nunes

Cordeiro

Beserra

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Justicia pectoralis Jacq. (Acanthaceae) leaves currently found in the Brazilian north-east are widely used to treat diabetes, menstrual pains, asthma, and other disorders. This work aimed to identify the phytochemical characterization and biological activities of J. pectoralis leaf extracts. The plant material was ground and the crude extracts were obtained with water or acetone: water (7:3 v/v), yielding aqueous (JPA), and organic (JPO) extracts. Phytochemical characterization was performed by thin-layer chromatography (TLC) and high-performance liquid chromatography (HPLC). Cytotoxicity was assessed by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) (MTT) assay and trypan blue (TB) exclusion assay in peripheral blood mononuclear cells (PBMCs), BALB/c splenocytes, and neoplastic cells (TOLEDO, K562, DU-145, and PANC-1) at 1, 10, and 100 μg/mL. Antibacterial activity was evaluated using the microdilution test to obtain the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). Cytokines, IFN-γ, and IL-17A from culture supernatants of BALB/c mice splenocytes were measured by sandwich ELISA. In the TLC analysis, both JPA and JPO extracts presented coumarin and flavonoids. In addition, HPLC was able to identify coumarin, apigenin, and ellagic acid in both extracts. JPO IC50 was 57.59 ± 1.03 μg/mL (MTT) and 69.44 ± 8.08 μg/mL (TB) in TOLEDO. MIC value of JPO against Acinetobacter baumannii and Klebsiella pneumoniae was 500 μg/mL. JPO (100 μg/mL) significantly inhibited IFN-γ levels (p=0.03). J. pectoralis is a potential candidate to be further investigated as an IFN-γ inhibitory agent and against Acinetobacter baumannii and Klebsiella pneumoniae.

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“…Moreover, the extract was tested on guinea-pig tracheal contraction caused by the cumulative dosing of histamine. Justicia pectoralis reduced histamine-induced tracheal smooth muscle contractions (Cameron et al, 2015).…”

Section: Hedera Helix L -Araliaceae (Leaves)mentioning

confidence: 94%

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

et al. 2020

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Background: Current recommendations for the self-management of SARS-Cov-2 disease (COVID-19) include self-isolation, rest, hydration, and the use of NSAID in case of high fever only. It is expected that many patients will add other symptomatic/adjuvant treatments, such as herbal medicines. Aims: To provide a benefits/risks assessment of selected herbal medicines traditionally indicated for "respiratory diseases" within the current frame of the COVID-19 pandemic as an adjuvant treatment. Method: The plant selection was primarily based on species listed by the WHO and EMA, but some other herbal remedies were considered due to their widespread use in respiratory conditions. Preclinical and clinical data on their efficacy and safety were collected from authoritative sources. The target population were adults with early and mild flu symptoms without underlying conditions. These were evaluated according to a modified PrOACT-URL method with paracetamol, ibuprofen, and codeine as reference drugs. The benefits/risks balance of the treatments was classified as positive, promising, negative, and unknown. Results: A total of 39 herbal medicines were identified as very likely to appeal to the COVID-19 patient. According to our method, the benefits/risks assessment of the herbal medicines was found to be positive in 5 cases (Althaea officinalis, Commiphora molmol, Glycyrrhiza glabra, Hedera helix, and Sambucus nigra), promising in 12 cases (Allium sativum, Andrographis paniculata, Echinacea angustifolia, Echinacea purpurea, Eucalyptus globulus essential oil, Justicia pectoralis, Magnolia officinalis, Mikania glomerata, Pelargonium sidoides, Pimpinella anisum, Salix sp, Zingiber officinale), and unknown for the rest. On the same grounds, only ibuprofen resulted promising, but we could not find compelling evidence to endorse the use of paracetamol and/or codeine. Conclusions: Our work suggests that several herbal medicines have safety margins superior to those of reference drugs and enough levels of evidence to start a clinical

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Preliminary Investigations of the Anti-asthmatic Properties of the Aqueous Extract of Justicia pectoralis (Fresh cut)

Cited by 9 publications

References 18 publications

Inhibitory effects of a standardized extract ofJusticia pectoralisin an experimental rat model of airway hyper-responsiveness

Inhibitory effects of a standardized extract ofJusticia pectoralisin an experimental rat model of airway hyper-responsiveness

Organic Extract of Justicia pectoralis Jacq. Leaf Inhibits Interferon‐γ Secretion and Has Bacteriostatic Activity against Acinetobacter baumannii and Klebsiella pneumoniae

COVID-19: Is There Evidence for the Use of Herbal Medicines as Adjuvant Symptomatic Therapy?

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