A crude extract of the leaves Justicia pectoralis reduced the formation of histamine-induced wheals in sensitized guinea pigs (p < 0.05) and also reduced histamine-induced tracheal smooth muscle contractions (p < 0.05). It blocked the effect of contraction produced by histamine in the airways; this property supports folklore claims for its use as an antihistamine.
ObjectiveTo evaluate the diuretic activity of Cassia occidentalis leaf and seed extracts, and to determine their effects on AST and ALP levels in Sprague Dawley rats.MethodDiuretic activity of hexane, ethyl acetate, methanol and aqueous extracts from the leaves and seeds of Cassia occidentalis (100 mg/kg) were evaluated using the Lipschitz model in Sprague Dawley rats. (n=6). Frusemide (20 mg/kg) was used as the positive control. All substances were administered orally. Animals were placed in metabolism cages and urine collected over a 24 hrs period. Results were represented as urine volume per body weight (mL/kg). Sodium, potassium and chloride ion concentrations in urine were also determined. Blood was collected before and 24 hrs after administration of extracts to obtain AST and ALP levels using an auto analyser system.ResultsThe mean urine volume collected from groups administered methanol and aqueous extracts from leaves of Cassia occidentalis were 19.02 mL/kg (p=0.009) and 18.81 mL/kg (p=0.017) respectively. Aqueous extract from the seeds of Cassia occidentalis was the only extract from the seeds that produced an increase in mean urine volume (20.78 mL/kg; p=0.003). Urine volume produce by all three extracts were significantly higher when compared to control (9.80 mL/kg). Sodium, potassium and chloride ion urine concentrations significantly increased after the administration of methanol and aqueous extract from the leaves of Cassia occidentalis. Frusemide produced a mean urine volume of 39.48 mL/kg (p<0.001) and an increase in sodium, potassium and chloride ions concentration.All groups were observed to have a reduction in AST and ALP levels.ConclusionThe study revealed that methanol and aqueous extracts from the leaves of Cassia occidentalis have diuretic effects. These extracts also significantly increased urine levels of sodium, potassium and chloride and reduced AST and ALP levels.This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal.
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