Preliminary evaluation of BMP-2-derived peptide in repairing a peri-implant critical size defect: A canine model

Chao, Yueh-Ling; Lin, Li‐Deh; Chang, Hao Hueng; Wang, Tong-Mei

doi:10.1016/j.jfma.2020.07.023

Cited by 11 publications

(12 citation statements)

References 17 publications

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“…In recent years, BMP-2 derived peptides have provided an alternative solution to the BMP-2 growth factor. BMP-2 peptides have more stable structural characteristics and retains its osteogenic properties ( Chao et al, 2021 ). PEG-based hydrogels carrying BMP-2 peptides have broad application prospects.…”

Section: Application Of Drug Delivery System Based On Peg Hydrogels I...mentioning

confidence: 99%

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Sun

Cui

Yuan

et al. 2023

Front. Bioeng. Biotechnol.

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Drug delivery systems composed of osteogenic substances and biological materials are of great significance in enhancing bone regeneration, and appropriate biological carriers are the cornerstone for their construction. Polyethylene glycol (PEG) is favored in bone tissue engineering due to its good biocompatibility and hydrophilicity. When combined with other substances, the physicochemical properties of PEG-based hydrogels fully meet the requirements of drug delivery carriers. Therefore, this paper reviews the application of PEG-based hydrogels in the treatment of bone defects. The advantages and disadvantages of PEG as a carrier are analyzed, and various modification methods of PEG hydrogels are summarized. On this basis, the application of PEG-based hydrogel drug delivery systems in promoting bone regeneration in recent years is summarized. Finally, the shortcomings and future developments of PEG-based hydrogel drug delivery systems are discussed. This review provides a theoretical basis and fabrication strategy for the application of PEG-based composite drug delivery systems in local bone defects.

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Section: Application Of Drug Delivery System Based On Peg Hydrogels I...mentioning

confidence: 99%

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Sun

Cui

Yuan

et al. 2023

Front. Bioeng. Biotechnol.

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“…Chao et al 138 surgically prepared 24 saddle‐shaped alveolar defects (10 mm mesial‐distal and 4 mm apical‐coronal) in the alveolar ridges of four male Beagle dogs treated with four different materials. The results showed that the BMP‐2 peptides can accelerate bone regeneration around implants 138 . As shown in Figure 3D, Xu et al depict the surgery procedure by which a bone defect was created after mandibular premolar extraction and subsequent installation of the implant into the distal region of the bone defect 110 …”

Section: Implantation Defect Models (Include Alveolar Ridge Expansion...mentioning

confidence: 99%

Oral hard tissue defect models for evaluating the regenerative efficacy of implant materials

Sun

Heng

Zhang

2023

MedComm – Biomaterials and Applications

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Oral hard tissue defects are common concomitant symptoms of oral diseases, which have poor prognosis and often exert detrimental effects on the physical and mental health of patients. Implant materials can accelerate the regeneration of oral hard tissue defects (such as periodontal defects, alveolar bone defects, maxilla bone defects, mandible bone defects, alveolar ridge expansion, and site preservation), but their regenerative efficacy and biocompatibility need to be preclinically validated in vivo with animal‐based oral hard tissue defect models. The choice of oral hard tissue defect model depends on the regenerative effect and intended application of the tested implant material. At the same time, factors that need to be considered include techniques for constructing the particular defect model, the scaffold/graft material used, the availability of animal model evaluation techniques and instrumentation, as well as costs and time constraints. In this article, we summarize the common oral hard tissue defect models in various animal species (such as periodontal model, jaw defect model, and implantation defect model) that can be used to evaluate the regenerative efficacy and biocompatibility of implant materials.

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“…BMP derived peptide has the advantages of small molecular weight, good chemical stability, flexible application and low economic cost, so it has higher application safety and biological effect ( Beauvais et al, 2016 ; Li A. et al, 2021 ; Meng et al, 2021 ). BMP derived peptide can also activate osteogenic differentiation pathway and promote osteoblast differentiation, thus inducing differentiation and osteogenesis ( Caron et al, 2021 ; Chao et al, 2021 ).…”

Section: Advanced Research Progress On the Biological Function Of Bmp...mentioning

confidence: 99%

“…BCP and TCP scaffolds have a high degree of biocompatibility and can support the attachment, proliferation and differentiation of osteoblasts, thereby promoting the formation of bone tissues. Thus, increasing research has been conducted on these materials ( Bosemark et al, 2015 ; Ishack et al, 2017 ; Quade et al, 2020 ; Chao et al, 2021 ). Although calcium phosphate shows a chemical composition similar to that of inorganic bone, its osteogenic performance is restricted by its low degradation rate and poor bone induction.…”

Section: Applications Of Bmps In Bone Tissue Engineeringmentioning

confidence: 99%

Application of BMP in Bone Tissue Engineering

Zhu

Liu

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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At present, bone nonunion and delayed union are still difficult problems in orthopaedics. Since the discovery of bone morphogenetic protein (BMP), it has been widely used in various studies due to its powerful role in promoting osteogenesis and chondrogenesis. Current results show that BMPs can promote healing of bone defects and reduce the occurrence of complications. However, the mechanism of BMP in vivo still needs to be explored, and application of BMP alone to a bone defect site cannot achieve good therapeutic effects. It is particularly important to modify implants to carry BMP to achieve slow and sustained release effects by taking advantage of the nature of the implant. This review aims to explain the mechanism of BMP action in vivo, its biological function, and how BMP can be applied to orthopaedic implants to effectively stimulate bone healing in the long term. Notably, implantation of a system that allows sustained release of BMP can provide an effective method to treat bone nonunion and delayed bone healing in the clinic.

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Preliminary evaluation of BMP-2-derived peptide in repairing a peri-implant critical size defect: A canine model

Cited by 11 publications

References 17 publications

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Oral hard tissue defect models for evaluating the regenerative efficacy of implant materials

Application of BMP in Bone Tissue Engineering

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