Drug delivery systems based on polyethylene glycol hydrogels for enhanced bone regeneration

Abstract

Drug delivery systems composed of osteogenic substances and biological materials are of great significance in enhancing bone regeneration, and appropriate biological carriers are the cornerstone for their construction. Polyethylene glycol (PEG) is favored in bone tissue engineering due to its good biocompatibility and hydrophilicity. When combined with other substances, the physicochemical properties of PEG-based hydrogels fully meet the requirements of drug delivery carriers. Therefore, this paper reviews the application of PEG-based hydrogels in the treatment of bone defects. The advantages and disadvantages of PEG as a carrier are analyzed, and various modification methods of PEG hydrogels are summarized. On this basis, the application of PEG-based hydrogel drug delivery systems in promoting bone regeneration in recent years is summarized. Finally, the shortcomings and future developments of PEG-based hydrogel drug delivery systems are discussed. This review provides a theoretical basis and fabrication strategy for the application of PEG-based composite drug delivery systems in local bone defects.

A novel hydrogel‐based moisturizing cream composed of hyaluronic acid for patients with xerosis: An intraindividual comparative analysis

“…PEG has many advantages in the field of drug delivery and tissue engineering 26 . It is characterized by its high solubility in organic solvents, non‐toxicity, lack of immune responses, and excellent biocompatibility 26 .…”

“…PEG has many advantages in the field of drug delivery and tissue engineering 26 . It is characterized by its high solubility in organic solvents, non‐toxicity, lack of immune responses, and excellent biocompatibility 26 . It can easily encapsulate and release drugs, making it a valuable material in the pharmaceutical industry 27 .…”

Engineering Hydrogels for Affinity-Based Release of Therapeutic Proteins

“…105 PEG has been synthesized to have a variety of terminal functional groups, including azide, alkyne, amino, maleic anhydride, acrylate, and carboxyl moieties for cross-linking with itself or other polymers. 106 For example, PEGs functionalized with acrylate groups, such as PEG-diacrylate (PEGDA) and PEGdimethacrylate (PGDMA), are photo-cross-linkable in the presence of UV light and a photoinitiator or chemically crosslinked using Michael-type addition to form hydrogels. Van de Wetering et al used Michael-type addition to cross-link an eight-arm PEG acrylate and dithiothreitol (DTT) to encapsulate and control the release of human growth hormone (hGH) (Figure 1I).…”

“…PEG cross-linkers can be bi- or multifunctional . PEG has been synthesized to have a variety of terminal functional groups, including azide, alkyne, amino, maleic anhydride, acrylate, and carboxyl moieties for cross-linking with itself or other polymers . For example, PEGs functionalized with acrylate groups, such as PEG-diacrylate (PEGDA) and PEG-dimethacrylate (PGDMA), are photo-cross-linkable in the presence of UV light and a photoinitiator or chemically cross-linked using Michael-type addition to form hydrogels.…”

Cryopreservation of Cell Sheets for Regenerative Therapy: Application of Vitrified Hydrogel Membranes

“…PEG has been used as a medical material for a long time. PEG-based materials are the most well-known DDS carriers made of PEG [ 68 , 69 , 70 ]. They can improve blood retention and enhance drug efficacy, but are not biodegradable or cell-adhesive.…”