Pregnancy in women with cystic fibrosis

Assessment of a novel genetic counselling intervention to inform assisted reproductive technology treatments and other family-building options in adults with cystic fibrosis

“…When both parents are carriers, defined as two individuals who each carry one deleterious allele of the same autosomal-recessive condition, they have a 25% chance of having a child affected with that condition (Myring et al, 2011). However, when a single individual with two deleterious alleles, diagnosed with an autosomal-recessive condition themselves, has a child with an individual who is a carrier of the same condition, the chance of having an affected child increases to 50% (Edenborough et al, 1995). This increased risk can play a large part in reproductive decision-making for adults with CF and their partners.…”