Medical and obstetric complications among pregnant women with cystic fibrosis

Patel, Emily; Swamy, Geeta K.; Heine, R. Phillips; Kuller, Jeffrey A.; James, Andra H.; Grotegut, Chad A.

doi:10.1016/j.ajog.2014.07.018

Cited by 106 publications

(55 citation statements)

References 31 publications

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“…Our primary outcome measure was weeks of gestation due to the higher risk of prematurity, which had been reported in women with CF [4,20,25]. Secondary outcomes were obstetrical (onset of labour, delivery type) and newborn parameters (birth weight, APGAR score, arterial cord pH, and indications for neonatal hospitalisation when applicable).…”

Section: Data Collectionmentioning

confidence: 99%

“…This multiorgan disorder affects the respiratory, gastrointestinal and reproductive systems [2] as a result of a genetic defect on chromosome 7 leading to abnormalities of the cystic fibrosis transmembrane conductance regulator (CFTR) protein [3]. Because of improvements in survival rates and thanks to the growing number of adult patients, the number of pregnancies in women with CF has been steadily increasing [4], as reported by the CF patient registries (45e61 onsets of pregnancies per year in France from 2011 to 2013 [1] and 257 pregnancies in the USA in the year 2013 [5]).…”

Section: Introductionmentioning

confidence: 99%

“…Although several of these studies reported obstetrical outcomes in pregnant women with CF, no comparison with pregnant women from the general population had been undertaken. Recently, Patel et al compared medical and obstetrical complications among pregnant women with and without CF from a large national database, but could not detail the individual characteristics of CF patients [4]. We decided to conduct a case-control study comparing the maternal and foetal outcomes of pregnancies in women with CF cared for at our CF centre and those of women from the general population using data from medical records.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Maternal and perinatal outcomes of pregnancies in women with cystic fibrosis – A single centre case-control study

Girault

Blanc

Gayet

et al. 2016

Respiratory Medicine

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Section: Data Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Maternal and perinatal outcomes of pregnancies in women with cystic fibrosis – A single centre case-control study

Girault

Blanc

Gayet

et al. 2016

Respiratory Medicine

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“…The increasing life expectancy of the CF population necessitates more attention to transition to adulthood and expected health care issues in young adults, including the concerns of individuals with CF who are considering parenthood or becoming parents. [3][4][5][6][7][8] Specific CF-related reproductive health issues include infertility and impact of pregnancy (including lung function, gestational diabetes, and immune system impairment). [3][4][5][6][7][8][9][10] The topic of parenting with CF raises questions about shortened life expectancy in CF, the daily burdens of simultaneously managing a chronic illness and raising children, and other concerns.…”

Section: Introductionmentioning

confidence: 99%

Pursuing parenthood with cystic fibrosis: Reproductive health and parenting concerns in individuals with cystic fibrosis

Hailey

Tan

Dellon

et al. 2019

Pediatric Pulmonology

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Background As life expectancy for cystic fibrosis (CF) has increased in recent decades, more individuals with CF are becoming parents. The objectives of this study were to describe the parenting and reproductive health concerns of individuals with CF and to identify the psychosocial and educational needs related to parenthood with CF. Methods Twenty adults with CF, including parents and non‐parents, participated in one‐on‐one, semi‐structured interviews about reproductive health and parenting. Questions pertained to reproductive health knowledge, psychosocial adaptation to CF related to fertility and parenthood, parenting concerns in the context of CF, and psychosocial care needs. We performed thematic content analysis on interview transcripts and descriptive statistical analysis on participant demographics and health variables. Results A majority of participants (ten women and ten men, of whom half were parents) described their health as “stable” and “good/fair”; median FEV 1 was 66% predicted (range, 30‐105). Participants shared a range of experiences related to reproductive health discussions with CF care providers and expressed concerns about pregnancy, infertility, and adoption. Parents and non‐parents expressed concerns about balancing roles as parent and patient, the impact of anticipated health decline and early mortality on children, and communication with children. Participants identified a need for earlier, improved education for potential parents and resources for parents with CF. Conclusions Individuals with CF may not receive sufficient CF‐related reproductive health education, and they have wide‐ranging concerns about the intersecting roles of patient and parent. Results from this study can provide guidance for CF care providers to improve their understanding and response to the needs of individuals and families affected by CF.

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“…Several studies have reported favorable maternofetal outcomes during and following pregnancy in women with CF, whereas others described adverse outcomes. According to Patel et al [7] , women with CF are at increased risk of death, infectious morbidity, acute renal failure, preterm labor among other obstetric complications and require more mechanical ventilation. While pregnancy and motherhood do not appear to accelerate disease progression up to 11 years after pregnancy, they are linked to a higher frequency of illness-related medical visits, pulmonary exacerbations, and a decrease in some domains of quality of life [3] .…”

Section: Introductionmentioning

confidence: 99%

Safety of Drugs during Pregnancy and Breastfeeding in Cystic Fibrosis Patients

Panchaud

Paolo²,

Koutsokera³

et al. 2016

Respiration

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Health management of cystic fibrosis (CF) patients should be maximized during pregnancy and breastfeeding because of its significant impact on the maternal and newborn outcomes. Thus, numerous drugs will have to be continued during pregnancy and lactation. Most of the drugs representing CF treatment lines cross the placenta or are excreted into human milk. Research addressing the risks and benefits of drugs used in CF patients during pregnancy and lactation is often incomplete or challenged by limited methodology, which often leads to conflicting or inconclusive results. Yet, potential treatment benefits for CF pregnant patients most often outbalance potential risks for the unborn child.

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Medical and obstetric complications among pregnant women with cystic fibrosis

Cited by 106 publications

References 31 publications

Maternal and perinatal outcomes of pregnancies in women with cystic fibrosis – A single centre case-control study

Maternal and perinatal outcomes of pregnancies in women with cystic fibrosis – A single centre case-control study

Pursuing parenthood with cystic fibrosis: Reproductive health and parenting concerns in individuals with cystic fibrosis

Safety of Drugs during Pregnancy and Breastfeeding in Cystic Fibrosis Patients

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