Pregnancy derived from human zygote pronuclear transfer in a patient who had arrested embryos after IVF

Zhang, Junyi; Zhuang, Guang-lun; Zeng, Yong; Grifo, James A.; Acosta, Carlo; Shu, Yaqing; Liu, Hui

doi:10.1016/j.rbmo.2016.07.008

Cited by 102 publications

(75 citation statements)

References 41 publications

(47 reference statements)

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“…Finally, while in some jurisdictions the clinical use of MRT is unlawful or its regulation non-existent or unclear 43,44 , there have been two reports of the modification of embryos through MRT and their subsequent transfer to women 45,46 . Zhang et al 45 described the use of PNT to establish a pregnancy for a 30-year-old nulligravid woman with unexplained infertility.…”

Section: Mrt In Humans: Research and Clinical Applicationsmentioning

confidence: 99%

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Assisted reproductive technologies to prevent human mitochondrial disease transmission

et al. 2017

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Section: Mrt In Humans: Research and Clinical Applicationsmentioning

confidence: 99%

“…Zhang et al 45 described the use of PNT to establish a pregnancy for a 30-year-old nulligravid woman with unexplained infertility. After the transfer of five embryos, a triplet pregnancy resulted that was surgically reduced to twins.…”

Section: Mrt In Humans: Research and Clinical Applicationsmentioning

confidence: 99%

Assisted reproductive technologies to prevent human mitochondrial disease transmission

et al. 2017

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“…In 2003 a team in China lead by Prof. John Zhang attempted a similar procedure involving mitochondrial transfer in a human IVF procedure. Although three foetuses developed, it did not result in any live births (Cohen and Malter 2016;Zhang et al 2016a). In September 2016 it was announced that Prof. Zhang's new USA based team had again conducted a mitochondrial donation IVF technique, this time performing the procedure in Mexico, and this time leading to the birth of a seemingly healthy baby boy (Hamzelou 2016;Zhang et al 2016b).…”

Section: Mitochondrial Donation and Crispr/cas9mentioning

confidence: 93%

Debating CRISPR/cas9 and Mitochondrial Donation: Continuity and Transition Performances at Scientific Conferences

Stephens

Dimond²

2016

Engaging STS

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Conferences are important performative sites. Here we detail a UK science policy conference debating the novel biomedical techniques CRISPR/cas9 and mitochondrial donation. Both techniques have received significant attention from scientists and bioethicists about their clinical potential, social implications, and the prospects of genetic and germline modification. In many countries the policy debates on regulating both technologies is ongoing and operating in tandem. The UK, however, is operating in a distinct policy context in that mitochondrial donation was formally legalized under license in 2015, meaning the British CRISPR/cas9 debates occur in the light of a confirmed policy position on mitochondrial donation. Our analysis of the Progress Educational Trust 2015 annual conference 'From Three-Person IVF to Genome Editing' argues that this event conducted important staging work in articulating the relationship between these two technologies in the UK. These efforts constitute what we call a 'transition performance' that (i) enacted the successful resolution of the mitochondrial donation policy debate, (ii) performed the success of British biomedical politics, and (iii) opened the space for a public debate on CRISPR/cas9 in line with a specifically configured set of legitimacy practices. Subsequently the conference contrasts to many other conferences that fit what we term a 'continuity performance' that seek to assert consistency and progress through iteration. We close by articulating further applications and developments of these notions in Science and Technology Studies.

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“…Dette har vaert vellykket gjennomført på aper (Macaca mulatta) (Tachibana 2009) og er nylig tillatt brukt for mennesker i Storbritannia. Vellykket mitokondriedonasjon er også nylig rapportert hos mennesker i Mexico (Hamzelou 2016;Zhang 2016). Man ser for seg at denne og lignende metoder vil utvide de reproduktive mulighetene til mange som har eller er baerere av alvorlige sykdommer, og bidra til å unngå at det blir født barn med slike sykdommer.…”

Section: Teknologier Som Endrer Grunnleggende Egenskaperunclassified

Etiske utfordringer med nyere reproduksjonsteknologi

Hofmann¹

2017

Etikk Praksis - Nord J Appl Ethics

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Many persons previously infertile, or who risked having diseased children, can now have healthy children. At the same time, these technological opportunities also raise a wide range of moral questions, which rarely have easy answers. One reason for this is that they are based on profound ethical challenges. This article sets out to give a short overview of three types of technologies: assisting, selective, and characteristicchanging technologies. It goes on to highlight some of the important moral questions raised by these technologies. The third part addresses the basic ethical challenges lurking behind the moral questions and debates. The fourth part addresses some forgotten or hidden questions, arguing that these are telling and important.This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Pregnancy derived from human zygote pronuclear transfer in a patient who had arrested embryos after IVF

Cited by 102 publications

References 41 publications

Assisted reproductive technologies to prevent human mitochondrial disease transmission

Assisted reproductive technologies to prevent human mitochondrial disease transmission

Debating CRISPR/cas9 and Mitochondrial Donation: Continuity and Transition Performances at Scientific Conferences

Etiske utfordringer med nyere reproduksjonsteknologi

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