Pregnancy and rheumatoid arthritis

Ince-Askan, Hilal; Dolhain, Radboud J E M

doi:10.1016/j.berh.2015.07.001

Cited by 44 publications

(28 citation statements)

References 102 publications

(139 reference statements)

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“…If taken during the peri-conception period, they have been associated with prolonged TTP and miscarriage [11,17,40]. Moreover, they can impair glomerular filtration of the foetus, inducing oligohydramnios, and prolong labour by inhibiting prostaglandins synthesis, which represent important mediators for uterine contractions [11,17,40].…”

Section: Nsaidsmentioning

confidence: 99%

“…In addition, gestational hypertension and pre-eclampsia have been inconstantly associated with active RA [11,14,15].…”

Section: Introductionmentioning

confidence: 96%

“…An increased risk of preterm delivery and small for gestational age infants from RA women has been described. Likewise, high disease activity has been associated with lower birth weight [10][11][12]. Recently, de Steenwinkle et al have demonstrated that high levels of circulating IL-6 (a pro-inflammatory cytokine) in the first trimester were associated with lower birth weight [13].…”

Section: Introductionmentioning

confidence: 98%

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Challenges and treatment options for rheumatoid arthritis during pregnancy

Gerosa

Schioppo

Meroni

2016

Expert Opinion on Pharmacotherapy

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A great body of evidence suggest that hydroxychloroquine, sulfasalazine, and non-fluorinated steroids can be continued throughout pregnancy, while methotrexate and leflunomide should be discontinued 3 months before pregnancy. Continuation of TNFi during the first part of pregnancy should be considered when benefits outweigh the potential risk of teratogenicity. Data regarding other biologics are scant and, at present, they should be stopped before pregnancy.

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Section: Nsaidsmentioning

confidence: 99%

“…In addition, gestational hypertension and pre-eclampsia have been inconstantly associated with active RA [11,14,15].…”

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 98%

See 1 more Smart Citation

Challenges and treatment options for rheumatoid arthritis during pregnancy

Gerosa

Schioppo

Meroni

2016

Expert Opinion on Pharmacotherapy

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“…Sex hormones were thought to play a role in the pathogenesis and also in the improvement of RA during pregnancy, due to their effects on the immune system [18]. RA could be induced or aggravated by many factors, among which mental factors play a large part in terms of its development, aggravation and recurrence.…”

Section: Balance Between Neuroendocrine System and Immune Systemmentioning

confidence: 99%

Five Balances in the Management of Rheumatoid Arthritis

Zou¹

2017

JBM

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Rheumatoid arthritis (RA) is the most common chronic autoimmune joint disease. The etiology of RA is complex, and then it is impossible to cure completely today and it should be individualized treatment. Immune system is complex. Existing statistical techniques based on reductionism cannot discover many relevant disease risk factors and complex interaction relationship. The disease network model based on complex network is important for the analysis and treatment of RA disease. In this Review, we have found five important layers of RA complex network and presented five balances regulating strategy in the management of RA. We have followed up one RA patient (wife of the author) for one year using this strategy, and the management effect is good. This Review argues RA is self-limiting to some extent, and good management with five balances regulating strategy would have positive significance, among which the balance between neuroendocrine system and immune system is the most important. During the day, glucocorticoid plays an important role in controlling inflammation, and human growth hormone plays an important role in eliminating inflammation during the slow-wave sleep at night. Five balances core concepts can shed light on the management of other causes of arthritis.

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“…Yan etkilerin çok görülmesinin sebebi bu ilaçların yüksek dozda uzun süre kullanılmaları ve genellikle 65 yaş üstü hastalarda kullanılmalarıdır. En önemli yan etki gastrointestinal yan etkilerdir (26).…”

Section: Yan Etkileriunclassified