Gebeli̇kte Non-Steroi̇dal Anti̇i̇nflamatuvar İlaçlarin Kullaniminin Değerlendi̇ri̇lmesi̇

Özbudak, Hatice; Ünal, Zeynep; Sabuncupğlu, Suna

doi:10.12991/mpj.20162059818

Cited by 7 publications

(8 citation statements)

References 17 publications

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“…18-21st and 56-60th days of pregnancy are the most sensitive period of gestation for teratogenic effect to fetüs. [1][2] Threshold levels of drugs for teratogenic effects are related to dosage, exposure period, tissue specific effect, placental passage, maternal body mass index, maternal metabolism, and maternal and fetal age. [3][4] Generalization of planned pregnancies with family planning services, detection of gestation and prescribing effective drugs at minimal effective doses according to gestational weeks, prevention of drug use without physician's prescription, pre-pregnancy counselling is important to ensure safe medication use for both mother and fetus.…”

Section: Introductionmentioning

confidence: 99%

Medication use in pregnancy: a cross-sectional, multinational web-based study

et al. 2014

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ObjectivesIntercountry comparability between studies on medication use in pregnancy is difficult due to dissimilarities in study design and methodology. This study aimed to examine patterns and factors associated with medications use in pregnancy from a multinational perspective, with emphasis on type of medication utilised and indication for use.DesignCross-sectional, web-based study performed within the period from 1 October 2011 to 29 February 2012. Uniform collection of drug utilisation data was performed via an anonymous online questionnaire.SettingMultinational study in Europe (Western, Northern and Eastern), North and South America and Australia.ParticipantsPregnant women and new mothers with children less than 1 year of age.Primary and secondary outcome measuresPrevalence of and factors associated with medication use for acute/short-term illnesses, chronic/long-term disorders and over-the-counter (OTC) medication use.ResultsThe study population included 9459 women, of which 81.2% reported use of at least one medication (prescribed or OTC) during pregnancy. Overall, OTC medication use occurred in 66.9% of the pregnancies, whereas 68.4% and 17% of women reported use of at least one medication for treatment of acute/short-term illnesses and chronic/long-term disorders, respectively. The extent of self-reported medicated illnesses and types of medication used by indication varied across regions, especially in relation to urinary tract infections, depression or OTC nasal sprays. Women with higher age or lower educational level, housewives or women with an unplanned pregnancy were those most often reporting use of medication for chronic/long-term disorders. Immigrant women in Western (adjusted OR (aOR): 0.55, 95% CI 0.34 to 0.87) and Northern Europe (aOR: 0.50, 95% CI 0.31 to 0.83) were less likely to report use of medication for chronic/long-term disorders during pregnancy than non-immigrants.ConclusionsIn this study, the majority of women in Europe, North America, South America and Australia used at least one medication during pregnancy. There was a substantial inter-region variability in the types of medication used.

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Section: Introductionmentioning

confidence: 99%

Medication use in pregnancy: a cross-sectional, multinational web-based study

et al. 2014

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“…COX-2 defektli dişi farelerin sıklıkla infertil oldukları, COX-1 defektli dişi farelerin ise fertil olduğu ancak bunlarda doğum defektleri olduğu gösterilmiştir (14). Bazı çalışmalarda yine prenatal NSAİİ kullananlarda düşük riskinde artış olduğu gösterilmiştir (15) (13). Biz çalışmamızda yavru sıçanlarda herhangi bir teratojen etki tesbit etmedik.…”

Section: Bulgularunclassified

An investigation of the effects of diclofenac sodium applied to pregnant rats on postnatal uterus: A stereological study.

Karakoç¹,

Çölçimen²,

Rağbetli³

2018

Van Med J

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“…Çocuklar; fizyolojik, psikolojik ve zihinsel gelişimlerinin farklılığı bakımından ilaç kullanırken titizlik gösterilmesi Tablo 5. Nonsteroidal anti-inflamatuar ilaçların sık rastlanan ya da ciddi olabilen bazı karşıt etkileri ve uygunluk sorunları (1, 16,17,20,22,[25][26][27][28][29].…”

Section: C Uygunluğuunclassified

“…Aspirinin laktasyon döneminde de kullanılması önerilmez. Bebekte Reye sendromuna yol açabilir; bebeğin K vitamini depoları az ise trombosit fonksiyonlarını bozabilir ve ayrıca hipoprotrombinemi yapabilir (17,26). Gebelikte NSAİİ kullanımı olası yararın ortaya çıkabilecek risklerin üzerinde olduğu durumlar dışında önerilmemektedir.…”

Section: Gebelik/fötusunclassified