Five Balances in the Management of Rheumatoid Arthritis

Abstract

Rheumatoid arthritis (RA) is the most common chronic autoimmune joint disease. The etiology of RA is complex, and then it is impossible to cure completely today and it should be individualized treatment. Immune system is complex. Existing statistical techniques based on reductionism cannot discover many relevant disease risk factors and complex interaction relationship. The disease network model based on complex network is important for the analysis and treatment of RA disease. In this Review, we have found five important layers of RA complex network and presented five balances regulating strategy in the management of RA. We have followed up one RA patient (wife of the author) for one year using this strategy, and the management effect is good. This Review argues RA is self-limiting to some extent, and good management with five balances regulating strategy would have positive significance, among which the balance between neuroendocrine system and immune system is the most important. During the day, glucocorticoid plays an important role in controlling inflammation, and human growth hormone plays an important role in eliminating inflammation during the slow-wave sleep at night. Five balances core concepts can shed light on the management of other causes of arthritis.

Clinical effects of Arabic gum (Acacia): A mini review

“…Numerous chronic diseases such as arthritis, cancer, diabetes, cardiovascular (CV) and neurological diseases were reported to be instigated by chronic inflammation (49) . Rheumatoid arthritis (RA) is an autoimmune illness recognized by chronic synovial inflammation with higher female incidence (50) . Tumor necrosis factor-α (TNF-α) is a main pro-inflammatory mediator involved in the development of RA (51) .…”

Immunological, Physiological, Andbiochemical Study of Some Patients With Rheumatoid Arthritis in Kirkuk City

“…Rheumatoid arthritis (RA) is an autoimmune disorder characterized by chronicsynovial inflammation. RA occurs when autoimmune response leads totissue damage which is mostly caused by type III hypersensitivity, with the participation of antibodies, complement, antigen-antibody complex, macrophages, T and B cells (1) ; leading to chronic progressive joint destruction causing a decline in quality of life, physical function, and working ability (2) .Small joints of the hands and feet are more frequently affected, by which the main characteristics of RA are stiffness and swelling of the joints as a result of inflammation of the synovium (3) . IL-6 is 26 kDa, four-helical glycopeptidepleiotropic cytokine mediates several biological functions, including regulation of the immune system,regenerative processes, metabolism, bone homeostasis,cardiovascular protection and neural function.…”

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“…населення [2]. Актуальність проблеми РА зумовлена й соціальним аспектом, а саме високою частотою поширеності цієї хвороби у популяції з типовим розвитком у хворих тимчасової та стійкої непрацездатності [3,4]. РА характеризується запаленням та набряком синовіальної оболонки суглоба з подальшим руйнуванням суглобових структур.…”