Prefrontal mediation of age differences in cognitive reappraisal

Opitz, Philipp C.; Rauch, Lindsay C.; Terry, Douglas P.; Urry, Heather L.

doi:10.1016/j.neurobiolaging.2010.06.004

Cited by 146 publications

(163 citation statements)

References 27 publications

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“…This slight separation in function is consistent with previous research, as the insula is proposed to be important in the conscious feeling of urge and craving (see Naqvi & Bechara, 2008), and the vlPFC has been associated with cognitive reappraisal (Opitz, Rauch, Terry & Urry, 2012;Wager, Davidson, Hughes, Lindquist & Ochsner, 2008).…”

Section: Discussionsupporting

confidence: 91%

Alpha activity in the insula accompanies the urge to neutralize in sub-clinical obsessive-compulsive participants

Jones¹,

Bhattacharya²

2012

Journal of Behavioral Addictions

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Background and aims:The behavioural addiction model of obsessive-compulsive disorder (OCD) proposes that as compulsions successfully reduce obsession-provoked anxiety in the early stages of the disorder, their performance is rewarding and therefore potentially addictive. According to this theory, the urge to perform a compulsion or neutralization resembles craving in addiction, and ventral fronto-striatal reward circuitry is activated during compulsive or neutralizing behaviour, resembling substance addiction disorders. The current study used EEG source localisation to test this hypothesis by examining brain activity accompanying the urge to neutralize and covert neutralization. Methods: Two groups of non-clinical participants (15 Low-OC, 15 High-OC) performed a task in which the urge to neutralize was induced by supplying participants with an obsessive-compulsive-like thought. Source localised EEG activity was compared between a negative condition with high urge to neutralize, and a positive condition with low urge to neutralize, and correlations between brain activity and self-reported urge to neutralize were examined. Results: High-OC participants reported a significantly greater urge to neutralize than Low-OC participants, and the majority of participants reported performing covert neutralization during the experiment. Between-condition comparisons in the High-OC group revealed significantly greater alpha activity in the insula and vlPFC in the negative than the positive condition, which was significantly correlated with both urge to neutralize and later decrease in negative affect. Conclusions: The current results support the proposal that the urge to neutralize in OCD is neurally similar to craving in substance addiction, in agreement with the behavioural addiction model of OCD.

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Section: Discussionsupporting

confidence: 91%

Alpha activity in the insula accompanies the urge to neutralize in sub-clinical obsessive-compulsive participants

Jones¹,

Bhattacharya²

2012

Journal of Behavioral Addictions

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“…Effect ratios were calculated to express the amount of the total e ect that is explained by the (total) indirect effects via the mediators. Because of the previously reported di erences in the use of cognitive emotion regulation strategies across demographical groups [39][40][41][42], age and gender were included as covariates.…”

Section: Statistical Analysesmentioning

confidence: 99%

Cognitive emotion regulation and stress: a multiple mediation approach

Miklósi¹,

Martos

Szabó

et al. 2014

Translational Neuroscience

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IntroductionStress de ned in terms of perceptions of uncontrollability and unpredictability has been one of the central issues in behavioural medicine, partly because of its negative impact on physical and mental health [1]. Though recent studies have underlined the e ects of stress on brain functioning, stress-related changes in cognitive processes of emotion regulation have been under-investigated [2].Emotion regulation has been de ned as the physiological, motivational, behavioural, and cognitive processes responsible for monitoring, evaluating, and modifying emotional reactions in order to accomplish one's goals [3], and has been considered to be important for understanding the onset, maintenance, and treatment of anxiety disorders (see [4] for review).Cognitive regulation of emotion refers to conscious cognitive methods of emotion regulation including attentional and evaluative processes [5,6]. A possible way to characterize cognitive strategies of emotion regulation is in terms of the involvement of the executive functions [7,8]. Executive cognitive emotion regulation, e.g. reappraisal, implies the use of higher cognitive processes such as mental set-shifting, evaluation, planning, working memory, and information updating and monitoring, whereas non-executive cognitive strategies, such as rumination, are associated with deficits in executive functions, e.g. attentional in exibility or inhibitory de cits [8]. For example, reappraisal was shown to be associated with enhanced a ective exibility [9], interference resolution [10], and working memory capacity [11], while rumination was associated with decreased cognitive exibility [12] and internal shifting impairments in working memory [13].Converging results have revealed that negative emotional states are strongly related to the excessive use of non-executive cognitive emotion regulation strategies, particularly rumination, catastrophizing, and self-blame.Low use of executive strategies, such as positive reappraisal, has also been found to be connected to psychopathology [e.g. 14-17], as well as to negative emotional states such as irritability and anger [18].Executive functions depend on the structural and functional integrity of the prefrontal cortex (PFC) [19], which guides emotions and behaviour through projections to subcortical regions like the hypothalamus and the amygdala [20]. Under safe conditions, the amygdala, which has been suggested to serve as a rapid detector of potential threats, is under tonic inhibitory control by the PFC.Under stressful conditions, critical areas of the PFC become hypoactive, resulting in a hyperactivation of the amygdala, which leads to the evocation of adaptive fear responses, but might also lead to chronic threat perception and sustained fear in unpredictable conditions (see [21] for review). Recent research in animal modelsdemonstrates that exposure to stress is regulation has yet to be investigated. The present study explores the possible role of cognitive emotion regulation strategies in mediating the well-establishe...

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“…In other words, different regulation strategies may be applied more successfully at different times of life (e.g. Opitz, Rauch, Terry, & Urry, 2012;Isaacowitz & BlanchardFields, 2012).…”

Section: Discussionmentioning

confidence: 99%