Preferential induction of apoptotic cell death in melanoma cells as compared with normal keratinocytes using a non-thermal plasma torch

Biophysical Effects of Cold Atmospheric Plasma on Glial Tumor Cells

“…Other publications corroborated these findings comparing effects of CAP on melanoma cells and keratinocytes [45], ovarian cancer cells and 40 3 Discussion fibroblasts [46], human lung cancer cell lines and human lung normal cell lines [47] as well as glioma cells and human embryonic kidney (HEK) cells [48]. The disadvantages of these approaches are the lack of comparability between the used cell lines and used plasma devices (e.g.…”

“…The WHO grading of CNS tumors established a malignancy scale based on histologic features, i.e. infiltration of surrounding tissue, genetic markers of the tumor, and disease progression, defining four categories of astrocytomas: the more circumscribed pilocytic astrocytoma are defined as grade I, diffusely infiltrative astrocytic tumors with cytological atypia are grade II (diffuse astrocytoma), tumors also showing anaplasia and mitotic activity are grade III (anaplastic astrocytoma), and those additionally showing microvascular proliferation and necrosis are grade IV [45]. Glioblastomas, embryonal neoplasms, and gliosarcomas are examples of grade IV neoplasms.…”

Plasma-activated medium induces A549 cell injury via a spiral apoptotic cascade involving the mitochondrial–nuclear network

“…In these studies on clinical applications, a low dose of plasma was reported to be able to induce the proliferation of cells, while a high dose induced apoptosis in cells [4,9]. Several studies in which applications for cancer therapy were designed demonstrated that plasma treatments killed cancer cells more effectively than normal cells [10][11][12].Recent studies reported that plasma affected cancer cells not only directly, but also by the indirect treatment of cells with previously prepared medium or water irradiated by plasma, termed plasma-activated medium (PAM) or plasma-activated water (PAW), respectively [8,[13][14][15]. The effectiveness of PAM promoted the potential of clinical applications of plasma medicine because PAM can be prepared in advanced and stored until use.…”

Evaluation of non-thermal plasma-induced anticancer effects on human colon cancer cells

“…The activation of caspase-3 has been observed during apoptotic cell death in many types of cancer cells in previous studies as well [38]. In addition, many researchers have reported that the tumor cell selectivity of non-thermal plasma was compared between normal cells and cancer cells such as skin cancer cells [39], lung cancer cells [40], glioma cells [41], and ovarian cancer cells [42]. From these previous reports, we suggest that non-thermal plasma specifically induces the oncogenic colon cell death or has mild effects on non-oncogenic cells.…”