“…In further studies, we investigated the metabolism of Phe-1,2-diol, Phe-3,4-diol, Phe-1,2-D-3,4-E, and Phe-3,4-D-1,2-E in human hepatocytes (Hecht et al, 2009). Consistent with the results of our analyses of human urine, we found that GSH conjugation of the reverse diol epoxide Phe-3,4-D-1,2-E was strongly favored over conjugation of the bay region diol epoxide Phe-1,2-D-3,4-E (Hecht et al, 2009). Taken together, these results were quite surprising because they seemed to contradict the hypothesis that carcinogenic bay region diol epoxides, such as Phe-1,2-D-3,4-E and BPDE, were detoxified by GST-catalyzed conjugation.…”