Metabolites of the PAH diol epoxide pathway and other urinary biomarkers of phenanthrene and pyrene in workers with and without exposure to bitumen fumes

Lotz, Anne; Pesch, Beate; Dettbarn, G.; Raulf, Monika; Welge, Peter; Rihs, Hans‐Peter; Breuer, D.; Gabriel, Stefan; Hahn, Jens‐Uwe; Brüning, Thomas; Seidel, Albrecht

doi:10.1007/s00420-016-1160-4

Cited by 16 publications

(12 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pesch et al (2011) found only a weak association between airborne concentrations of bitumen during a working shift and post-shift concentrations of urinary 1-OHP and hydroxy-phenanthrene metabolites and no association with hydroxy-naphthalene metabolites in 317 mastic asphalt workers compared to 117 unexposed reference controls. Lotz et al (2016) showed similar results investigating diol epoxide pathways of phenanthrene (PHE) and phenolic pathways of PHE and pyrene in urine of 91 mastic asphalt workers compared to 42 unexposed reference controls, before and after work-shifts. Urinary diol epoxides of PHE and pyrene increased during and after shift and were highest in smokers.…”

Section: Category 4 -Not Assignablesupporting

confidence: 61%

“…Concern for high exposure, at higher application temperatures of bitumen in the small population of mastic workers in Germany resulted in the performance of the German Human Bitumen Study evaluating mastic asphalt workers (320 workers, 118 unexposed controls) employed in paving indoor garage spaces from 24 to 180 months. This extensive study produced six DNA adduct and strand break studies (Marcyznski et al 2006(Marcyznski et al , 2010(Marcyznski et al , 2011Raulf-Heimsoth et al 2011a, 2011bKendzia et al 2012), one cytogenetic study and two biomarker studies Lotz et al 2016). DNA strand breaks were higher in bitumen-exposed workers before and after work-shift compared to unexposed controls but strand break levels did not increase significantly during the work week.…”

Section: Category 4 -Not Assignablementioning

confidence: 99%

“…When considered with Marczynski et al (2011), a similar shift-work effect from general occupational exposure was observed, marginally enhanced by bitumen exposure but within the acceptable range of healthy individuals. Pesch et al (2011) and Lotz et al (2016) reported that PAC metabolites in urine of mastic asphalt workers could not be considered specific biomarkers of bitumen exposure in the workplace due to the weak correlation with airborne bitumen exposure levels. Smoking however showed strong impact on PAC metabolite concentrations.…”

Section: Category 4 -Not Assignablementioning

confidence: 99%

See 2 more Smart Citations

Assessing cancer hazards of bitumen emissions – a case study for complex petroleum substances

Kriech¹,

Schreiner²,

Osborn³

et al. 2017

Critical Reviews in Toxicology

View full text Add to dashboard Cite

When assessing cancer hazard and risk associated with a complex petroleum substance, like bitumen emissions, there are often conflicting results related to human, animal and mechanistic studies. Validation of the complex composition to assure that it matches real-world exposures and control of confounders are pivotal factors in study design to allow the necessary read-across during assessments. Several key studies on bitumen emissions in two-year dermal cancer assays reported variable outcomes ranging from high cancer incidence to no cancer incidence. Here, we synthesize findings from published studies to explain the differences and discuss critical factors in cancer hazard evaluation for complex petroleum substances. Using these critical factors, we reviewed relevant human genetic toxicity, mammalian toxicity and mechanistic studies with bitumen to understand the divergence in results. We assess the most reliable and scientifically supported information on the potential carcinogenic hazards of bitumen emissions and comment on quality and completeness of data. Human hazard data are typically considered highest priority because they eliminate the need for interspecies extrapolation and reduce the range of high -to low-dose extrapolation during the risk assessment process. Finally, two well-conducted comprehensive animal studies are discussed that have well-defined test material, exposure concentration and composition representative of worker exposure, evidence of systemic uptake, no confounding exposures and provide consistency across all elements within both studies. Studies that allow effective read-across from human, animal and mechanistic components, control for confounders and are well-validated analytically against workplace exposures, provide the strongest evidence base for evaluating cancer hazard. ARTICLE HISTORY

show abstract

Section: Category 4 -Not Assignablesupporting

confidence: 61%

Section: Category 4 -Not Assignablementioning

confidence: 99%

Section: Category 4 -Not Assignablementioning

confidence: 99%

See 1 more Smart Citation

Assessing cancer hazards of bitumen emissions – a case study for complex petroleum substances

Kriech¹,

Schreiner²,

Osborn³

et al. 2017

Critical Reviews in Toxicology

View full text Add to dashboard Cite

show abstract

“…During the hot application of bitumen, volatile and the most hazardous substances are released. They comprise aliphatic hydrocarbons and Polycyclic Aromatic Hydrocarbons (PAHs) [5].…”

Section: Introductionmentioning

confidence: 99%

“…Serum enzymes such as Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), and Alkaline Phosphatase (ALP) are good indicators of liver function [11]. The previous investigation on workers exposed to bitumen confirmed urinary PAHs metabolites in higher concentrations compared to the control group [5]. Elevated levels of GGT and ALT enzymes were reported in construction workers in previous studies [16].…”

Section: Introductionmentioning

confidence: 99%

Occupational Exposure to Paving Asphalt Fumes, Impact on Liver and Kidney Function Test Parameters

Noroozi

Akhgari

Abdollahi

2021

IJMTFM

View full text Add to dashboard Cite

Background: Asphalt is a mixture of aliphatic and aromatic hydrocarbons. It also contains different kinds of heavy metals. Hot mix asphalt emits hazardous volatile substances. Asphalt is used in many industries, causing serious adverse health effects for workers. Therefore, investigation of the health status of workers is of crucial importance. The present study aimed to assess the impact of asphalt vapor on hepatic and renal function tests parameters and the clinical parameters in road paving workers compared to healthy subjects. Methods: In a cross-sectional study, 41 road asphalt paving workers and 120 healthy non-exposed subjects were selected. The serum enzymes of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin, triglyceride, urea, and creatinine levels were assessed using diagnostic kits. A medical practitioner examined all subjects for any possible medical condition. Results: Liver and kidney function test parameters were significantly higher in road asphalt paving workers compared to their healthy counterparts (P<0.05 for all parameters). About 63% of workers exposed to asphalt fumes for more than 10 years showed cardiac, pulmonary, and metabolic complications. Conclusion: Significant elevations in liver and kidney function test parameters suggest that exposure to asphalt fumes is associated with hepatic and renal dysfunction in asphalt-exposed workers.

show abstract

Exposure to polycyclic aromatic hydrocarbons increases the risk of poor sleep pattern in US adults: results from the NHANES (2005–2010)

Zhang,

Peng,

Xin

et al. 2023

Environ Sci Pollut Res

View full text Add to dashboard Cite

Metabolites of the PAH diol epoxide pathway and other urinary biomarkers of phenanthrene and pyrene in workers with and without exposure to bitumen fumes

Cited by 16 publications

References 50 publications

Assessing cancer hazards of bitumen emissions – a case study for complex petroleum substances

Assessing cancer hazards of bitumen emissions – a case study for complex petroleum substances

Occupational Exposure to Paving Asphalt Fumes, Impact on Liver and Kidney Function Test Parameters

Exposure to polycyclic aromatic hydrocarbons increases the risk of poor sleep pattern in US adults: results from the NHANES (2005–2010)

Contact Info

Product

Resources

About