Predictive Value of the sFlt-1:PlGF Ratio in Women With Suspected Preeclampsia

Zeisler, Harald; Llurba, Elisa; Chantraine, Frédéric; Vatish, Manu; Staff, Annetine; Sennström, Maria; Olovsson, Matts; Brennecke, Shaun P.; Stepan, Holger; Allegranza, Deirdre; Dilba, Peter; Schoedl, Maria; Hund, Martin; Verlohren, Stefan

doi:10.1097/01.aoa.0000489468.07157.ab

Cited by 102 publications

(170 citation statements)

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“…No significant differences were found between groups regarding age ..no significant difference in gravidity and GA. SBP and DBP are higher in early than in late preeclampsia Table (1).…”

Section: Resultsmentioning

confidence: 99%

“…Preeclampsia(PE) a heterogeneous multisystem disorder defined by the new onset of hypertension and proteinuria after 20 weeks of gestation affects 2-5% of pregnancies worldwide .Preeclampsia is associated with high risks of iatrogenic preterm delivery, intrauterine growth restriction, placental abruption and perinatal mortality along with maternal morbidity and mortality [1].…”

Section: Introductionmentioning

confidence: 99%

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Role of MicroRNA-155 in Pathogenesis and Prognosis of Preeclampsia pregnancies

Tolba

Abdelrahman

Sakr

et al. 2020

Benha Journal of Applied Sciences

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Preeclampsia (PE) is a medical condition characterized by hypertension and proteinuria in pregnant females following 20 weeks of gestation. It is the most common cause of fetal morbidity and mortality, which has no curative therapeutic strategy, except for delivery of the placenta. The association between PE and aberrant microRNA (miRNA) expression in placentas was first reported in 2007 and a number of other similar findings have since been demonstrated.The aim of this study was to assess the level of expression of miR-155 in Egyptian women with preeclampsia and its role in pathogenesis and prognosis of the disease. This study was a case control study included a total of 40 pregnant females; 9 cases with early onset PEdiagnosed < 34 weeks of gestation whose mean age was 32.4 years, and 21 case of late onset PEdiagnosed ≥ 34 weeks of gestation whose mean age was 32.2 years admitted to the obstetrics and gynaecology department, Banha University Hospitals, in addition to 10 normotensive pregnant women of matched age as a control group. MIRNA 155 expression level were in PE cases when compared to control groups (p<0.001). MIRNA 155 expression level showed no significant difference between early onset and late onset PE. miRNA 155 expression showed significantly higher level in PE than normotensive pregnant females with no difference between early and late onset PE.

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“…No significant differences were found between groups regarding age ..no significant difference in gravidity and GA. SBP and DBP are higher in early than in late preeclampsia Table (1).…”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of MicroRNA-155 in Pathogenesis and Prognosis of Preeclampsia pregnancies

Tolba

Abdelrahman

Sakr

et al. 2020

Benha Journal of Applied Sciences

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“…At a UAS of 4, weekly clinical and Doppler sonographic checks are recommended. In this case, supplemental serum screening by sFlt-1/PlGF ratio is also discussed, but generally accepted management protocols are still pending [24].…”

Section: Monitoring Of High-risk Pregnanciesmentioning

confidence: 99%

Doppler ultrasound in pregnancy – quality requirements of DEGUM and clinical application (part 2)

Faber¹,

Steiner²,

Gembruch

2021

Ultraschall Med

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This second part on Doppler sonography in prenatal medicine and obstetrics reviews its clinical applications. While this has not become the initially anticipated screening tool, it is used for the diagnosis and surveillance of a variety of fetal pathologies. For example, the sonography-based determination of uterine artery blood flow indices is an important parameter for the first trimester multimodal preeclampsia risk assessment, increasing accuracy and providing indication for the prophylactic treatment with aspirin. It also has significant implications for the diagnosis and surveillance of growth-restricted fetuses in the second and third trimesters through Doppler-sonographic analysis of umbilical artery, middle cerebral artery and ductus venosus. Here, especially the hemodynamics of the ductus venosus provides a critical criterium for birth management of severe, early-onset FGR before 34 + 0 weeks of gestation. Further, determination of maximum blood flow velocity of the middle cerebral artery is a central parameter in fetal diagnosis of anemia which has been significantly improved by this analysis. However, it is important to note that the mentioned improvements can only be achieved through highest methodological quality. Importantly, all these analyses are also applied to twins and higher order multiples. Here, for the differential diagnosis of specific complications such as TTTS, TAPS and TRAP, the application of Doppler sonography has become indispensable. To conclude, the successful application of Doppler sonography requires both exact methodology and precise pathophysiological interpretation of the data.

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“…Angiogenic factors play an important role in the pathogenesis of placenta‐associated complications such as preeclampsia with and without HELLP syndrome 16 . Angiogenic profiling using the soluble fms‐like tyrosine kinase 1 (sFlt‐1)/placental growth factor (PlGF) ratio can be helpful to identify women with impending preeclampsia and these markers also have the potential to customize the management of patients with established preeclampsia, although this point is still controversial 17–19 . Data on angiogenic factors in AFLP are scarce.…”

Section: Introductionmentioning

confidence: 99%

Soluble fms‐like tyrosine kinase 1 (sFlt‐1): A novel biochemical marker for acute fatty liver of pregnancy

Trottmann

Raio

Amylidi-Mohr

et al. 2021

Acta Obstet Gynecol Scand

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Introduction: Acute fatty liver of pregnancy (AFLP) substantially contributes to maternal and neonatal morbidity and mortality. Other liver-associated pregnancy complications such as preeclampsia-associated HELLP (hemolysis, elevated liver enzyme, low platelet) syndrome may be difficult to differentiate from AFLP as these diseases overlap with regard to multiple clinical and laboratory features. The aim of this study was to investigate angiogenic profiles by measuring soluble fms-like tyrosine kinase-1 (sFlt-1) and placental growth factor (PlGF) in pregnancies compromised by AFLP and to compare them with those complicated by HELLP syndrome. Material and methods:Pregnant women affected by AFLP or HELLP syndrome were enrolled. The study population of women with HELLP syndrome was part of a larger data collection obtained in our clinic that has been used for previous work. Patients' angiogenic profiles were assessed by measuring sFlt-1 and PlGF serum levels. To assess the diagnostic potential of these angiogenic markers in AFLP, as well as discriminating it from HELLP syndrome, non-parametric tests were used and receiver operating curves were calculated.Results: Six women with AFLP and 48 women with HELLP syndrome were included in the study. Patients with AFLP showed significantly higher sFlt-1 levels (median: 57 570 pg/mL; range 31 609-147 170 pg/mL) than patients with HELLP syndrome (9713 pg/mL; 1348-30 781 pg/mL; p < 0.001). PlGF serum levels were higher in patients with AFLP compared with those with HELLP syndrome (197 pg/mL; 127-487 pg/mL vs. 40 pg/mL; 9-644 pg/mL, respectively; p < 0.01). sFlt-1/PlGF ratios were not significantly different between AFLP and HELLP syndrome patients (192; 157-1159 vs. 232; 3-948, respectively; NS). In our study population, an sFlt-1 cut-off value of 31 100 pg/mL allowed differentiation between these two diseases with a sensitivity and specificity of 100%. A linear correlation was found between the cumulative numbers of Swansea criteria and sFlt-1 serum levels (r = 0.97; p < 0.01).Conclusions: AFLP is associated with very high sFlt-1 serum levels in particular in women fulfilling eight or more Swansea criteria. Besides the suggested Swansea | 1877 TROTTMANN eT Al.

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Predictive Value of the sFlt-1:PlGF Ratio in Women With Suspected Preeclampsia

Cited by 102 publications

References 0 publications

Role of MicroRNA-155 in Pathogenesis and Prognosis of Preeclampsia pregnancies

Role of MicroRNA-155 in Pathogenesis and Prognosis of Preeclampsia pregnancies

Doppler ultrasound in pregnancy – quality requirements of DEGUM and clinical application (part 2)

Soluble fms‐like tyrosine kinase 1 (sFlt‐1): A novel biochemical marker for acute fatty liver of pregnancy

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