Predictive value of NLR and PLR in response to preoperative chemotherapy and prognosis in locally advanced gastric cancer

Abstract

PurposePretreatment neutrophil-to-lymphocyte (NLR) and platelet-to-lymphocyte (PLR) ratios are markers of systemic inflammation. In patients with locally advanced gastric cancer (GC), the utility of these ratios in predicting tumor regression grade (TRG) after neoadjuvant chemotherapy (NCT) remains unclear.MethodsThis retrospective study examined 283 locally advanced GC patients who underwent NCT and radical surgery. The receiver operating characteristic (ROC) curve analysis and the Youden index were applied to identify optimal NLR/PLR cutpoints. The Kaplan–Meier method was used to estimate overall survival (OS) and disease-free survival (DFS). Univariate/multivariate analyses were conducted by the logistic regression method.ResultsTRG grade proved significantly worse in patients with high values of both NLR and PLR whether in univariate (OR = 3.457; p = 0.044) or multivariate (OR = 6.876; p = 0.028) analysis. The degree of tumor differentiation was an independent predictive factor for TRG (OR = 2.874; p = 0.037) in multivariate analysis. In the subgroup analyses, NLR predicted OS (p = 0.04) and DFS (p = 0.03) in female patients, whereas PLR was predictive of both OS (p = 0.026) and DFS (p = 0.018) in patients with clinical TNM stage 3 disease and dissected lymph node counts <28. PLR similarly predicted OS in patients <65 years old (p = 0.049), those with positive lymph nodes (p = 0.021), or those with moderate or poorly differentiated tumors (p = 0.049).ConclusionPretreatment NLR and PLR together serve to independently predict TRG after NCT and surgery in patients with locally advanced GC. Screening for patients with high NLR and PLR values may allow them to benefit upfront from alternatives to NCT.

Hematological characteristics of COVID‐19 patients with fever infected by the Omicron variant in Shanghai: A retrospective cohort study in China

“…Elevated MLR has been reported to be a feature not only of COVID‐19 infection but also of diabetic kidney injury, 28 non‐alcoholic fatty liver disease (NAFLD), 29 and cancer 30,31 . Raised PLR has been also reported in other inflammatory conditions including liver fibrosis, 32 thyroid conditions, 33,34 diabetes mellitus, 35 and systemic lupus erythematosus 36 . Increased MPR has been shown to be associated with hepatitis B‐related liver fibrosis, 32 sepsis, 37 and cancer 38 .…”

Prognostic efficacy of platelet/lymphocyte ratio and neutrophil/lymphocyte ratio in patients with gastric cancer [Version 1; Peer Review - In Progress]

“…Este conocimiento ha llevado a la realización de diversos estudios que han relacionado tanto el NLR como el PLR con el pronóstico en los diferentes tipos de cáncer como el de próstata, renal, gástrico, etc. (6,7,8,14,15,16,17,18,19,20,21,22,23) Para que se dé el proceso inflamatorio es necesario la participación de distintas células sanguíneas (neutrófilos, plaquetas, linfocitos, etc. ), siendo los neutrófilos, un subgrupo de leucocitos involucrados principalmente en este proceso.…”

“…(17) Estudios previos informaron que una alta expresión de varios subtipos de linfocitos infiltrantes de tumores (TIL), como CD8+ o CD3+, se asocia con un mejor pronóstico en el cáncer gástrico. (28,29) Los resultados obtenidos de estos marcadores inflamatorios revisados en varios trabajos de investigación (14,15,16,17,18,19,20,21,22) se correlacionan con estudios realizados de otros tumores como el cáncer renal (6) y el de próstata (8) . Aquí se muestran que valores elevados de los cocientes PLR y NLR generan un peor pronóstico en pacientes con cáncer.…”

Hematological parameters in patients with acnes

“…Previous studies have proved that NLR and PLR are predictive biomarkers. Wentao Wang et al 13 demonstrated that pretreatment NLR and PLR together serve to independently predict tumor regression grade after neoadjuvant chemotherapy and surgery in patients with advanced gastric cancer (GC). In addition, it has been reported that NLR and PLR were found to be predictive markers of lymph node metastasis of GC patients, and NLR is better to predict overall survival than PLR 22 .…”

“…6 Mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), platelet to lymphocyte ratio (PLR), lymphocyte to monocyte ratio (LMR), and systemic immune-inflammation index (SII) as diagnosis and prognostic biomarkers were used for the inflammatory disease and tumor, [7][8][9][10] illustrating hidradenitis suppurativa, 11 seborrheic dermatitis, 12 and gastric cancer. 13 Complete blood count (CBC) is one of the most common laboratory tests performed for patient, influenced by many conditions. 14 Novel biomarkers of CBC parameters for inflammation have been the subject of extensive studies, but few studies have evaluated the relationship between acne vulgaris and CBC parameters.…”