Predictive value of earl embryonic cardiac activity for pregnancy outcome

Merchiers, E; Dhont, Marc; Sutter, Paul A. De; Beghin, C.; Vandekerckhove, D

doi:10.1016/0002-9378(91)90214-c

Cited by 60 publications

(33 citation statements)

References 7 publications

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“…Reduced oxygen tension at higher altitude alters CV function, reduces fetal growth, and increases fetal demise (8). Variations in oxygen tension during development due to maternal cyanotic congenital heart disease also increase fetal loss and growth restriction (9). Although it is clear that reduced oxygen tension impacts fetal growth and survival, there are limited data on the role of hypoxia in directly regulating embryonic CV growth and function during the period of primary cardiac morphogenesis.…”

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confidence: 99%

Impact of Hypoxia on Early Chick Embryo Growth and Cardiovascular Function

et al. 2006

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Oxygen tension is a critical factor for appropriate embryonic and fetal development. Chronic hypoxia exposure alters cardiovascular (CV) function and structure in the late fetus and newborn, yet the immature myocardium is considered to be less sensitive to hypoxia than the mature heart. We tested the hypothesis that hypoxia during the period of primary CV morphogenesis impairs immature embryonic CV function and embryo growth. We incubated fertile white Leghorn chick embryos in 15% oxygen (hypoxia) or 21% oxygen (control) until Hamburger-Hamilton stage 21 (3.5 d). We assessed in ovo viability and dysmorphic features and then measured ventricular pressure and dimensions and dorsal aortic arterial impedance at stage 21. Chronic hypoxia decreased viability and embryonic wet weight. Chronic hypoxia did not alter heart rate or the ventricular diastolic indices of end-diastolic pressure, maximum ventricular -dP/dt, or tau. Chronic hypoxia decreased maximum ventricular ϩdP/dt and peak pressure, increased ventricular end-systolic volume, and decreased ventricular ejection fraction, consistent with depressed systolic function. Arterial afterload (peripheral resistance) increased and both dorsal aortic SV and steady-state hydraulic power decreased in response to hypoxia. Thus, reduced oxygen tension during early cardiac development depresses ventricular function, increases ventricular impedance (afterload), delays growth, and decreases embryo survival, suggesting that a critical threshold of oxygen tension is required to support morphogenesis and cardiovascular function in the early embryo. (Pediatr Res 59: 116-120, 2006)

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confidence: 99%

Impact of Hypoxia on Early Chick Embryo Growth and Cardiovascular Function

et al. 2006

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“…During the following 3 weeks, there is a rapid increase up to 180 beats per minute. 5,6 Table 2 summarizes the features of normal early pregnancy.…”

Section: The Embryonic Periodmentioning

confidence: 99%

SOGC Clinical Practice Guidelines: Ultrasound Evaluation of First Trimester Pregnancy Complications

Creinin

2006

Journal of Obstetrics and Gynaecology Canada

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“…5 Therefore assessment of fetal heart rate in early pregnancy is effective tool for clinical decision-making. 6 The fetal heart rate in early pregnancies gradually increases until a stable normal heart rate is reached. 7 Even ultrasound proven viability of early pregnancy, monitoring heart rate can also predict the outcome of fetus.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Normal Heart Rate in Early Pregnancy Corresponding to Gestational Age between Six to Eight Weeks

Jha¹,

Rimal²,

Khatun

2017

Med Phoenix

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REsEaRCH aBstRaCtBackground: Ultrasonography is the reliable and safe way for the evaluation of pregnancy. Heart rate can be detected more confidently from the Ultrasonography. Heart rate is an important parameter for the evaluation of early pregnancy. The purpose of this study was to evaluate the normal heart rate in embryos/fetuses between 6 and 8 weeks of gestation. Method:In our region people are poor and most of them do not know the benefit of regular follow up examination during pregnancy. So most of pregnant women come to our centre at late stage of pregnancy. The number of pregnancy cases is good in our centre but the number of early pregnancy cases coming to regular follow up examination is low. Thus the study was conducted in 51 normal singleton pregnancies undergoing routine ultrasound examination during the first trimester of pregnancy. The duration of study was 6 weeks.Result: Out of 51 singleton pregnancies, 20 cases (39.2%) heart rate were between 131-150 beat per minute and 25 cases (49.0 %) heart rate were between 151-170 beat per minute. However 4 cases (7.8%) were between 110-120 beat per minute and 2 cases (3.9%) were more than 171 beat per minute. There were zero cases above the 180 beat per minute. Conclusion:The result of this study will help to evaluate abnormal and normal fetal heart rate so that early clinical decision whether to continue the pregnancy or terminate it can be taken, as Ultrasonography is only the method used in screening fetal well being in most of the region of our country.

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Predictive value of earl embryonic cardiac activity for pregnancy outcome

Cited by 60 publications

References 7 publications

Impact of Hypoxia on Early Chick Embryo Growth and Cardiovascular Function

Impact of Hypoxia on Early Chick Embryo Growth and Cardiovascular Function

SOGC Clinical Practice Guidelines: Ultrasound Evaluation of First Trimester Pregnancy Complications

Evaluation of Normal Heart Rate in Early Pregnancy Corresponding to Gestational Age between Six to Eight Weeks

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