Predictive equation of metastasis in patients with malignant ovarian epithelial tumors with the Ca-125 marker

Vega, Juan Fernando Sánchez; Bacilio, Magdali del Rocío Murillo; Condoy, Adrián Santiago Vintimilla; González, Araceli Miroslava Palta; Astudillo, José Alfredo Crespo; Bravo, Franklin Geovany Mora

doi:10.1186/s12885-018-4499-y

Cited by 9 publications

(7 citation statements)

References 11 publications

(16 reference statements)

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“…Interestingly, recent studies report that the binding mesothelin to Ca125 plays a crucial role in metastasis creation via spreading ovarian cancer cells in the peritoneal cavity [ 54 , 55 ]. Numerous studies reported increased concentration of Ca125 in ovarian cancer patients enhances the motility and invasiveness of cancer cells that lead to metastasis related to metastasis creation and disease progression [ 56 , 57 , 58 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical and Prognostic Value of Antigen-Presenting Cells with PD-L1/PD-L2 Expression in Ovarian Cancer Patients

Pawłowska

Kwiatkowska

Suszczyk

et al. 2021

IJMS

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The latest literature demonstrates the predominant role of the programmed cell death axis (PD-1/PD-L1/PD-L2) in ovarian cancer (OC) pathogenesis. However, data concerning this issue is ambiguous. Our research aimed to evaluate the clinical importance of PD-L1/PD-L2 expression in OC environments. We evaluated the role of PD-L1/PD-L2 in OC patients (n = 53). The analysis was performed via flow cytometry on myeloid (mDCs) and plasmacytoid dendritic cells (pDCs) and monocytes/macrophages (MO/MA) in peripheral blood, peritoneal fluid (PF), and tumor tissue (TT). The data were correlated with clinicopathological characteristics and prognosis of OC patients. The concentration of soluble PD-L1 (sPD-L1) and PD-1 in the plasma and PF were determined by ELISA. We established an accumulation of PD-L1+/PD-L2+ mDCs, pDCs, and MA in the tumor microenvironment. We showed an elevated level of sPD-L1 in the PF of OC patients in comparison to plasma and healthy subjects. sPD-L1 levels in PF showed a positive relationship with Ca125 concentration. Moreover, we established an association between higher sPD-L1 levels in PF and shorter survival of OC patients. An accumulation of PD-L1+/PD-L2+ mDCs, pDCs, and MA in the TT and high sPD-L1 levels in PF could represent the hallmark of immune regulation in OC patients.

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Section: Discussionmentioning

confidence: 99%

Clinical and Prognostic Value of Antigen-Presenting Cells with PD-L1/PD-L2 Expression in Ovarian Cancer Patients

Pawłowska

Kwiatkowska

Suszczyk

et al. 2021

IJMS

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“…Blood markers to monitor ovarian cancers can be physiologically raised during pregnancy [1]. Abnormal level of CA125 is widely used in epithelial ovarian cancer detection and monitoring [9]. CA 125 is often elevated at 1st trimester and its level is low in maternal serum but high in the amniotic fluid in 2nd and 3rd trimester so it still has diagnosis value for 2nd and 3rd trimester [3].…”

Section: Discussionmentioning

confidence: 99%

Long-term multidisciplinary integrative therapy management resulted in favorable outcomes for ovarian cancer during pregnancy: a case report and literature review

Wang

Jia

et al. 2019

J Ovarian Res

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BackgroundOvarian cancer during pregnancy is relatively rare and treatment strategies are inexperienced in surgery and chemotherapy. Multidisciplinary management of advanced epithelial ovarian cancer in pregnant patients with strong desire of fertility including sufficient mental and medical understanding, perioperative consideration, intraoperative decision, chemotherapy sensitivity and follow-up after treatment can gain successful outcomes for both maternal disease and fetus’s development.Case presentationA 34-year-old primigravidae was diagnosed with advanced epithelial ovarian tumor and then first cytoreductive surgery to resect macroscopical lesions and protect the uterus for fetus was performed following with four chemotherapy courses (docetaxel and carboplatin) before delivery and four other chemotherapy courses after delivery. Chemotherapy drugs were decided by sensitivity test and the patient’s anaphylaxis. Second surgery involved cesarean section with a healthy offspring and secondary cytoreductive surgery. Operative strategies were considered to gain a balance of disease and risk for fetus. Psychosocial support was provided during the course of diagnosis and treatment for a healthy coping situation. This patient relapsed 19 months after the last chemotherapy course and was treated by additional adjuvant therapy to a clinical remission. The 33-month baby boy has no evidence with disease until now. The follow-up of both mother and baby is still continuing.ConclusionsOvarian cancer during pregnancy has low incidence which must increase in future as women delay reproduction age. Ovarian cancer cytoreductive surgery and chemotherapy have limitation to handle conditions under a desire of fetus protection. Multidisciplinary treatment model is a therapeutic solution and a challenge for gynecological surgeons, medical oncologists, pathologists, obstetricians, neonatologists, pharmacists, anesthetist, and psychologists.

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“…A previous study indicated that the levels of SCCA were also increased in other types of cancer, including breast cancer (5). Sugar chain antigen 125 (CA-125) was used for the diagnosis of ovarian carcinoma and its sensitivity was primarily based on the staging of ovarian malignancies (6). However, it has been reported that the expression levels of CA-125 were also elevated in other malignancies, including ~10.4% of benign ovarian tumors (7).…”

Section: Introductionmentioning

confidence: 99%

Systematic re‑analysis strategy of serum indices identifies alkaline phosphatase as a potential predictive factor for cervical cancer

Zheng

Ding

et al. 2019

Oncol Lett

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The aim of the present study was to identify predictive factors for cervical cancer (CC) progression using a multistage approach. The present study obtained data from 390 healthy women and 259 patients with cervical cancer between June 2012 and June 2017, and used a multiple stage re-analysis strategy for clinical detection of CC. A total of seven types of serum indices were used in the present study, including sugar chain antigen 125 (CA-125), sugar chain antigen 199 (CA-199), α fetoprotein (AFP), carcino- embryonic antigen, alkaline phosphatase (ALP), cholesterol and triglyceride (TG). The expression levels of CA-125, CA-199, AFP, ALP, cholesterol and TG were significantly different between healthy women and patients with cervical squamous cell carcinoma (SCC). Furthermore, ALP, cholesterol and TG expression levels were significantly different in healthy women compared with patients with cervical adenocarcinoma (AC). Further comparisons based on age and pathological staging demonstrated that the variability in the ALP level was not significant between the <40 years old age group and the 40–50 years old age group within healthy individuals (P>0.05); however, was significant in patients with SCC (P<0.05). Staging analysis identified significant differences in ALP between healthy women and patients with SCC (Stage I–IV), and significant differences between healthy women and patients with Stage I AC. The results of the present study indicated that the expression of ALP was significantly increased in patients with CC compared with healthy women. Therefore, ALP may be a potential predictive factor for the development of CC.

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Predictive equation of metastasis in patients with malignant ovarian epithelial tumors with the Ca-125 marker

Cited by 9 publications

References 11 publications

Clinical and Prognostic Value of Antigen-Presenting Cells with PD-L1/PD-L2 Expression in Ovarian Cancer Patients

Clinical and Prognostic Value of Antigen-Presenting Cells with PD-L1/PD-L2 Expression in Ovarian Cancer Patients

Long-term multidisciplinary integrative therapy management resulted in favorable outcomes for ovarian cancer during pregnancy: a case report and literature review

Systematic re‑analysis strategy of serum indices identifies alkaline phosphatase as a potential predictive factor for cervical cancer

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