The latest literature demonstrates the predominant role of the programmed cell death axis (PD-1/PD-L1/PD-L2) in ovarian cancer (OC) pathogenesis. However, data concerning this issue is ambiguous. Our research aimed to evaluate the clinical importance of PD-L1/PD-L2 expression in OC environments. We evaluated the role of PD-L1/PD-L2 in OC patients (n = 53). The analysis was performed via flow cytometry on myeloid (mDCs) and plasmacytoid dendritic cells (pDCs) and monocytes/macrophages (MO/MA) in peripheral blood, peritoneal fluid (PF), and tumor tissue (TT). The data were correlated with clinicopathological characteristics and prognosis of OC patients. The concentration of soluble PD-L1 (sPD-L1) and PD-1 in the plasma and PF were determined by ELISA. We established an accumulation of PD-L1+/PD-L2+ mDCs, pDCs, and MA in the tumor microenvironment. We showed an elevated level of sPD-L1 in the PF of OC patients in comparison to plasma and healthy subjects. sPD-L1 levels in PF showed a positive relationship with Ca125 concentration. Moreover, we established an association between higher sPD-L1 levels in PF and shorter survival of OC patients. An accumulation of PD-L1+/PD-L2+ mDCs, pDCs, and MA in the TT and high sPD-L1 levels in PF could represent the hallmark of immune regulation in OC patients.
Introduction and hypothesis Pelvic organ prolapse (POP) treatment has become more common in the world's health care systems, and the demand for pelvic floor disorder rehabilitation has been projected to increase by 35% between 2010 and 2030. Restitution procedures vary, but after the US Food and Drug Administration (FDA) notifications, the global use of mesh in vaginal surgeries has significantly decreased. The aim of this study is to show trends in urogynecological surgeries in Poland. Methods Retrospective analysis was performed of data obtained between 2009 and 2017 from the National Health Fund Information Centre website. Vaginal hysterectomies (VH), POP and urinary incontinence (UI) surgeries were considered.
The aim of the study was to evaluate the influence of different types of hysterectomy on UI symptoms, quality of life and sexual functions using dedicated questionnaires. We investigated a correlation between the urethral length (UL), UI symptoms and the length of the cervix (left after LSH and SH) with sexual functions. The study enrolled 500 consecutive women referred for hysterectomy: 121 underwent VH, 171 underwent LSH, 96 underwent SH, 68 underwent TAH, and 44 underwent TLH. The patients filled in the UI-specific questionnaires and FSFI before and 12 months after hysterectomy. The UL was measured by introital ultrasound before and 12 months after hysterectomy. Before surgery, 137 out of 399 (34.3%) patients had UI symptoms; afterwards, 139 (34.8%) indicated the same (p > 0.05). There was no statistically significant difference in the UL in the patients before and after the procedure, and the cervix length did not differ between patients after LSH and SH. When the entire investigated population was analyzed, a significant improvement of the QoL was found on the IIQ-7. Hysterectomy performed due to benign diseases has effects on UI regardless of the surgical technique used. The UI symptoms improved only in the patients after LSH. The UL measured 12 months after hysterectomy did not change.
Introduction: Allogeneic haematopoietic stem cell transplantation (HSCT) is a well-established therapeutic option used in the treatment of malignant and non-malignant disorders. According to numerous studies, there is a correlation between donor sex or sex mismatching between donor and recipient and increased risk of graft-versus-host diseases. Aim of the study: The aim of this study was to assess the impact of donor-recipient sex mismatching on the incidence of transplant-related complications in children undergoing allogeneic HSCT. Material and methods: We conducted a retrospective study comparing the prevalence of transplant-related adverse events between female donor-female recipient, female donor-male recipient, male donor-male recipient, and male donor-female recipient groups. The study population included 198 patients from the department's database, who underwent allogeneic HSCT between 2001 and 2018 in the Department of Paediatric Haematology, Oncology, and Transplantology in Lublin. Results: No statistically significant differences in prevalence of transplant-related complications between the four groups were found in this study: acute graft-versus-host disease (p = 0.53), chronic graft-versus-host disease (p = 0.69), hepatic veno-occlusive disease (p = 0.41), renal failure (p = 0.81), bleeding (p = 0.51), cytomegaly virus infection (p = 0.41), Epstein-Barr infection (p = 0.29), and fungal infection (p = 0.31). Conclusions: The study showed no correlation between sex mismatching and HSCT complication frequency in children. The results of this study suggest that the donor's gender might not be a crucial factor in screening for potential donors in the paediatric population. Rising evidence of the lack of a direct impact of a donor's gender on overall HSCT transplant outcomes and adverse events in the paediatric population might in future change the criteria we follow when looking for potential donors. In conclusion, there is a need for prospective observational studies, which could investigate the mechanisms of adverse events and multicentre retrospective studies, which would allow larger homogeneous populations to be gathered to further research the impact of donor's demographics on allogeneic HSCT outcomes and complications.
No abstract
Background: We present a case an adolescent female patient with Gender Dysphoria (GD) who was diagnosed with a recurrent ovarian neoplasm - Juvenile Granulosa Cell Tumor (JGCT).Case presentation: A 17-year-old female patient presented multiple endocrine pathologies and a recurrent JGCT. During the surgery qualification process, the patient admitted to identifying herself as a male. The patient described being uncomfortable with her body and with the expected roles of her assigned gender. Due to that, the patient requested a total hysterectomy with a bilateral salpingo-oophorectomy. As a minor, she required parent permission, which was not granted. The patient underwent several specialist consultations, after which she agreed for unilateral removal of tumor-changed pathologies and additional hormonal, psychological, and psychiatric diagnostics.Conclusion: To the best of our knowledge, this is the first detailed report of co-occurrence of GD spectrum disorders and JGCT in an adolescent female. This case contains many therapeutic and ethical problems regarding both physical and mental health. It should be noted that adolescents with the GD spectrum rarely develop persistent transsexuality. Modulations from developmental psychology, psychotherapy, family dynamics, hormonal treatment, and the removal of JGCT in the presented case may have potential therapeutic implications for GD.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.