Prediction of mechanical behavior of 3D bioprinted tissue-engineered scaffolds using finite element method (FEM) analysis

Soufivand, Anahita Ahmadi; Abolfathi, Nabiollah; Hashemi, Seyyed Hamid; Lee, Sang Jin

doi:10.1016/j.addma.2020.101181

Cited by 29 publications

(39 citation statements)

References 28 publications

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“…Indeed, in this printing method, the filament adhesion is mainly because of interdiffusion phenomena that can control the mechanical response. Accordingly, this novel technology facilitates the manufacture of parts with complicated geometry [1] but with moderate bonding properties that can be improved by post-processing procedures, e.g., heating [6]. Therefore, using CZM in Mode I and II is essential to predict the mechanical properties because of this partial bonding between layers of FDM parts…”

Section: Discussionmentioning

confidence: 99%

“…The cutting-edge 3D printing technology fabricates objects by deposition of materials in the layer upon layer fashion [1,2]. According to ASTM F42, printing processes can be divide into seven subgroups of extrusion-based, powder bed fusion, binder jetting, material jetting, directed energy deposition, sheet lamination, and vat photo-polymerization processes [3].…”

Section: Introductionmentioning

confidence: 99%

“…Gremare et al performed tensile tests on the 3D printed PLA bone scaffold to examine the effect of pore dimension on the mechanical properties [15]. It is noticeable that the numerical FEM approach was used repeatedly in the literature to predict the mechanical response of FDM parts in silico very well [1,6,16]. On the other hand, in the experimental approach, fabrication of numerous specimens and performing mechanical tests to find an appropriate mechanical property for FDM parts are costly and time-consuming.…”

Section: Introductionmentioning

confidence: 99%

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Computing the bond strength of 3D printed polylactic acid scaffolds in mode I and II using experimental tests, finite element method and cohesive zone modeling

Nazemzadeh

Soufivand

Abolfathi

2021

Int J Adv Manuf Technol

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The advent of the Three-Dimensional (3D) printing technique, as an Additive Manufacturing (AM) technology, made the manufacture of complex porous scaffolds plausible in the tissue engineering field. In Fused Deposition Modeling (FDM) based 3D printing, layer upon layer deposition of filaments produces voids and gaps, leading to a crack generation and loose bonding.Cohesive Zone Model (CZM), a fracture mechanics concept, is a promising theory to study the layers bond behavior. In this paper, a combination of experimental and computational investigations was proposed to obtain bond parameters and evaluate the effect of porosity and microstructure on these parameters. First, we considered two different designs for scaffolds beside a non-porous Bulk design. Then, we performed Double Cantilever Beam (DCB) and Singe Lap Shear (SLS) tests on the 3D printed samples for Modes I and II, respectively. Afterward, we developed the numerical simulations of these tests using the Finite Element Method (FEM) to obtain CZM bond parameters. Results demonstrate that the initial stiffness and cohesive strength were pretty similar for all designs in Mode I. However, the cohesive energy for the Bulk sample was approximately four times of porous samples. Furthermore, for Mode II, the initial stiffness and cohesive energy of the Bulk model were five and four times of porous designs while their cohesive strengths were almost the same. Also, using cohesive parameters was significantly enhanced the accuracy of FEM predictions in comparison with fully bonded assumption. It can be concluded that for the numerical analysis of 3D printed parts mechanical behavior, it is necessary to obtain and suppose the cohesive parameters. The present work illustrates the effectiveness of CZM and FEM combination to obtain the layer adhesive parameters of the 3D printed scaffold.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Computing the bond strength of 3D printed polylactic acid scaffolds in mode I and II using experimental tests, finite element method and cohesive zone modeling

Nazemzadeh

Soufivand

Abolfathi

2021

Int J Adv Manuf Technol

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“…Other researchers preferred firstly to design the model using CAD software, representing it with filaments instead of as a solid part, and then print the scaffold [ 10 , 14 , 18 , 19 , 20 , 21 , 22 , 23 ]. In those cases, they were able to simulate the model behaviour and compare the results with the experimental ones or optimise the part before printing it.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, there are several valid options to simulate the mechanical performance of the printed scaffold based on its model, such as the homogenisation [24][25][26][27], the voxel-based [12,28,29], or the CAD-based modelling techniques [10,14,[18][19][20][21][22][23]30,31].…”

Section: Introductionmentioning

confidence: 99%

Comparison of CAD and Voxel-Based Modelling Methodologies for the Mechanical Simulation of Extrusion-Based 3D Printed Scaffolds

et al. 2021

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Porous structures are of great importance in tissue engineering. Most scaffolds are 3D printed, but there is no single methodology to model these printed parts and to apply finite element analysis to estimate their mechanical behaviour. In this work, voxel-based and geometry-based modelling methodologies are defined and compared in terms of computational efficiency, dimensional accuracy, and mechanical behaviour prediction of printed parts. After comparing the volumes and dimensions of the models with the theoretical and experimental ones, they are more similar to the theoretical values because they do not take into account dimensional variations due to the printing temperature. This also affects the prediction of the mechanical behaviour, which is not accurate compared to reality, but it makes it possible to determine which geometry is stiffer. In terms of comparison of modelling methodologies, based on process efficiency, geometry-based modelling performs better for simple or larger parts, while voxel-based modelling is more advantageous for small and complex geometries.

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Bioinspired 3D‐Printed Auxetic Structures with Enhanced Fatigue Behavior

Shirzad,

Kang,

Kim

et al. 2024

Adv Eng Mater

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Recently, auxetic metastructures have gained considerable attention in various fields of study due to their unique characteristics. In this study, we aim to design and fabricate bioinspired auxetic structures and comprehensively investigate the static and dynamic mechanical properties of those architectures under tensile and compressive loads. Comparative analysis is carried out with a conventional structure, considering static tensile and compressive tests, as well as dynamic tension‐tension and compression‐compression assessments. Experimental measurements and finite element analysis are utilized to evaluate various parameters of the scaffolds, such as Young’s modulus, yield strength, energy absorption, stress distribution, Poisson’s ratio, and fatigue properties. The findings indicate that bioinspired auxetic structures can appropriately mimic the physical attributes and stress‐strain characteristics of human tissue, such as the Achilles tendon. Furthermore, these bioinspired auxetic structures significantly enhance the cycles to failure compared to conventional structures, accompanied by notable improvements in energy absorption. Among the auxetic structures, the star configuration exhibits remarkable tolerance to tensile fatigue loads, while the sharp sinus structure demonstrates the highest tolerance to cycles to failure under compression‐compression loads. The static and fatigue properties of bioinspired auxetic structures indicate their potential for biomedical applications.This article is protected by copyright. All rights reserved.

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Prediction of mechanical behavior of 3D bioprinted tissue-engineered scaffolds using finite element method (FEM) analysis

Cited by 29 publications

References 28 publications

Computing the bond strength of 3D printed polylactic acid scaffolds in mode I and II using experimental tests, finite element method and cohesive zone modeling

Computing the bond strength of 3D printed polylactic acid scaffolds in mode I and II using experimental tests, finite element method and cohesive zone modeling

Comparison of CAD and Voxel-Based Modelling Methodologies for the Mechanical Simulation of Extrusion-Based 3D Printed Scaffolds

Bioinspired 3D‐Printed Auxetic Structures with Enhanced Fatigue Behavior

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