Prediction of developing metabolic syndrome after gestational diabetes mellitus

Akıncı, Barış; Çeltik, Aygül; Yener, Serkan; Yeşil, Sena

doi:10.1016/j.fertnstert.2008.12.007

Cited by 50 publications

(31 citation statements)

References 25 publications

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“…Using the ATP III and IDF definitions for metabolic syndrome, pre-pregnancy obesity, weight gain, and OGTT fasting glucose levels each predicted the development of metabolic syndrome. Moreover, even a fasting glucose concentration above 5.5 mmol/L at the antepartum OGTT was an independent predictor of metabolic syndrome (Akinci et al, 2010). Indeed, many studies have demonstrated an increased prevalence of features of the metabolic syndrome following GDM.…”

Section: Development Of Metabolic Syndrome After Gdmmentioning

confidence: 98%

Gestational Diabetes and the Metabolic Syndrome

Souza¹,

Ray²,

Retnakaran³

2011

Gestational Diabetes

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Section: Development Of Metabolic Syndrome After Gdmmentioning

confidence: 98%

Gestational Diabetes and the Metabolic Syndrome

Souza¹,

Ray²,

Retnakaran³

2011

Gestational Diabetes

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“…Higher fasting plasma glucose levels during pregnancy, after adjustment for BMI and age, have been shown to be predictors of the metabolic syndrome 40 months [6] and 8.5 years [7] after the index pregnancy. Similarly, we have previously shown that fasting plasma glucose levels during pregnancy and postpartum, and postpartum C-peptide and ghrelin levels, were significant risk factors for the development of type 2 diabetes in women with a previous history of GDM [8].…”

Section: Introductionmentioning

confidence: 99%

The prediction of type 2 diabetes in women with previous gestational diabetes mellitus using lipidomics

et al. 2015

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Aims/hypothesis The risk of developing diabetes is greater for women with previous gestational diabetes mellitus (GDM). In the general population, plasma lipidomic analysis can identify individuals at risk of developing type 2 diabetes. The aim of this study was to determine whether circulating lipid levels 12 weeks following a GDM pregnancy were associated with an increased risk of developing type 2 diabetes. Methods Plasma lipid profiles containing >300 lipids were measured in 104 normal glucose-tolerant women 12 weeks following an index GDM pregnancy using electrosprayionisation tandem mass spectrometry. Women were assessed for 10 years for development of overt type 2 diabetes. Results Among the 104 women with previous GDM, 21 (20%) developed diabetes during the median follow-up period of 8.5 years. Three lipid species, the cholesteryl ester species CE 20:4, the alkenylphosphatidylethanolamine species PE(P-36:2) and the phosphatidylserine species PS 38:4, were independently and positively associated with the development of type 2 diabetes. In a clinical model of prediction of type 2 diabetes that included age, BMI, and levels of pregnancy fasting glucose, postnatal fasting glucose, triacylglycerol and total cholesterol, the addition of these three lipid species resulted in an improvement in the net reclassification index of 22.3%. Conclusions/interpretation The lipid species CE 20:4, PE(P-36:2) and PS 38:4 were significant risk factors for the development of type 2 diabetes in women with a previous history of GDM. This report is the first to use plasma lipidomic analysis to identify individual lipids as potential biomarkers for the prediction of type 2 diabetes in women with a history of GDM.

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“…Obesity in GDM women may also predict metabolic syndrome at a postpartum time earlier than previously reported. 1,3,16,23 A GDM-complicated pregnancy may be an exclusive opportunity to assess the risk for early cardiovascular disease in the mother. Thus, this study is mainly aimed to identify the best glucose and weight-related, prenatal, factors in GDM women that highly predict early metabolic syndrome after delivery.…”

Section: Introductionmentioning

confidence: 99%