Prepregnancy Body Mass Index and Prenatal Fasting Glucose Are Effective Predictors of Early Postpartum Metabolic Syndrome in Spanish Mothers with Gestational Diabetes

Barquiel, Beatriz; Herranz, Lucrecia; Hillman, Natalia; Burgos, M.A.; Pallardo, Luís Felipe

doi:10.1089/met.2013.0153

Cited by 16 publications

(13 citation statements)

References 34 publications

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“…13 TG, TC and LDL concentrations were higher in the HDP/GDM group in the first trimester as shown above. These findings suggested that lipids in early gestational age show a more maternal metabolic condition than the physiological requirement for fetal growth.…”

Section: Discussionsupporting

confidence: 66%

Associations of lipid levels during gestation with hypertensive disorders of pregnancy and gestational diabetes mellitus: a prospective longitudinal cohort study

et al. 2016

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ObjectiveTo assess associations of elevated lipid levels during gestation with hypertensive disorders of pregnancy (HDP) and gestational diabetes mellitus (GDM).MethodsThis prospective cohort study was conducted in a tertiary maternal hospital in Shanghai, China from February to November 2014. Lipid constituents, including triglycerides (TGs), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c) and high-density lipoprotein cholesterol (HDL-c) of 1310 eligible women were assessed in the first (10–13+ weeks), second (22–28 weeks) and third (30–35 weeks) trimesters consecutively. Associations of lipid profiles with HDP and/or GDM outcomes were assessed.ResultsCompared with the normal group, maternal TG concentrations were higher in the HDP/GDM groups across the three trimesters (p<0.001); TC and LDL-c amounts were only higher in the first trimester for the HDP and GDM groups (p<0.05). HDL-c levels were similar in the three groups. Compared with intermediate TG levels (25–75th centile), higher TG amounts (>75th centile) were associated with increased risk of HDP/GDM in each trimester with aORs (95% CI) of 2.04 (1.41 to 2.95), 1.81 (1.25 to 2.63) and 1.78 (1.24 to 2.54), respectively. High TG elevation from the first to third trimesters (>75th centile) was associated with increased risk of HDP, with an aOR of 2.09 (1.16 to 3.78). High TG elevation before 28 weeks was associated with increased risk of GDM, with an aOR of 1.67 (1.10 to 2.54). TG elevation was positively correlated with weight gain during gestation (R=0.089, p=0.005).ConclusionsControlling weight gain during pregnancy could decrease TG elevation and reduce the risk of HDP/GDM. TGs could be used as follow-up parameters during complicated pregnancy, while other lipids are meaningful only in the first trimester.

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Section: Discussionsupporting

confidence: 66%

Associations of lipid levels during gestation with hypertensive disorders of pregnancy and gestational diabetes mellitus: a prospective longitudinal cohort study

et al. 2016

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“…Unlike our results, other studies showed an association between pre-gestational BMI indicative of overweight and obesity and the presence of MS in the postpartum period. 9,16,18 In these studies, however, MS was diagnosed in the postpartum period in women with a diagnosis of GDM who, according to the pre-gestational BMI, were overweight/obese and whose levels of fasting glucose were high. 9,16,18 In relation to the biochemical analysis, only the levels of HDL-c in the 16th week and the triglyceride levels in the postpartum period remained significantly associated with MS in this study.…”

Section: Discussionmentioning

confidence: 99%

“…9,16,18 In these studies, however, MS was diagnosed in the postpartum period in women with a diagnosis of GDM who, according to the pre-gestational BMI, were overweight/obese and whose levels of fasting glucose were high. 9,16,18 In relation to the biochemical analysis, only the levels of HDL-c in the 16th week and the triglyceride levels in the postpartum period remained significantly associated with MS in this study. Corroborating these findings, a study carried out at the beginning of the gestation showed higher average levels of triglycerides (192.5±87.5 mg/dl and 105±61.2 mg/dl) and lower HDL-c (456.79±114.2 mg/ dl and 532.92±152.26 mg/dl) in women with MS in comparison to those without it.…”

Section: Discussionmentioning

confidence: 99%

Metabolic syndrome in pregnancy and postpartum: prevalence and associated factors

Lima

Melo²,

Sena

et al. 2019

Rev. Assoc. Med. Bras.

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SUMMARY OBJECTIVE Evaluate the prevalence of metabolic syndrome (MS) and the main associated maternal factors in women without pre-gestational conditions, in early pregnancy and in the immediate postpartum. METHODS Two hundred pregnant women were evaluated at the 16th week of pregnancy, and 187 were reassessed postpartum. MS was diagnosed according to the criteria by the National Cholesterol Education Program Adult Treatment Panel III. In addition to the diagnostic criteria, anthropometric measures, blood pressure, metabolic profile, and visceral and subcutaneous fat thickness (by ultrasonography) were collected from the pregnant woman. The student’s t-test was used to compare the prevalence of MS and its components in the 16th week and in the postpartum. Multiple logistic regression was performed to identify the principal factors associated with the syndrome. RESULTS The prevalence of the MS was 3.0% in early pregnancy and 9.7% postpartum (p=0.01). Following multiple logistic regression, the prepregnancy body mass index (BMI) (p=0.04) and high-density lipoprotein cholesterol (HDL-c) (p=0.02) remained associated with MS at 16 weeks, and triglyceride levels evaluated in postpartum (p<0.001) with MS in postpartum. CONCLUSION The frequency of the MS was high in the immediate postpartum. The factors associated were prepregnancy BMI and HDL-c at the 16th week, as well as triglyceride levels postpartum.

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“…In South India, the reported incidence of postpartum DM among women with history of previous GDM is even higher within the first five years with over 90% being affected within 10 years of delivery [5]. After delivery, women with GDM often have an increased risk of developing metabolic syndrome, which is also seen in South Asian women [1,[6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of gestational diabetes mellitus in a Suburban District in Sri Lanka: a population based study

2016

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Introduction GDM is a leading metabolic cause of morbidity to mother and offspring. Determining its prevalence is important for health planning and implementation.Objective Assess prevalence of GDM in the District of Gampaha.Method Community based cross-sectional study was conducted in women attending field-based ante-natal clinics in two Medical Officer of Health (MOH) areas between January 2014 to March 2015.Consecutive women were recruited by cluster sampling with probability proportionate to size using strict exclusion criteria. GDM diagnosis was based on fasting 75 g OGTT, WHO 1999. All responders underwent 2 hr PPBS in first trimester->200 mg/dl with symptoms identified as abnormal, probably diabetes in pregnancy (DIP); those >120 and <200 mg/dl proceeded to OGTT before 16 weeks POA; all negatives were tested by OGTT between 24-28 weeks. Negatives for GDM at 24-28 weeks underwent OGTT between 32-36 weeks; venous plasma glucose tested by accredited laboratory.Results Sample consistedof 160, non-response 4.2% (67); 1533 underwent 2 hr PPBS with 40 exceeding 120mg: 4 >200 mg diagnosed as GDM / DIP, 36 (PPBS >120 < 200 mg) underwent OGTT before 16 weeks with 15 GDM. One hundred and thirty four (8.38%) miscarried including one with early abnormal OGTT. Of 1381 eligible for OGTT (24-28 weeks) 150 had GDM (10.86%). Only 344 (27.94% of normal 1231) consented for third trimester OGTT, of whom 25 had GDM-yielding a total of 194 with GDM (13.9%). ConclusionThe current community prevalence of GDM in the suburban Gampaha District, Sri Lanka is high.

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Prepregnancy Body Mass Index and Prenatal Fasting Glucose Are Effective Predictors of Early Postpartum Metabolic Syndrome in Spanish Mothers with Gestational Diabetes

Abstract: Women having GDM are at threat of early postpartum metabolic syndrome. This risk can be easily identified by assessing prepregnancy BMI and antenatal fasting glycemia in the first pregnancy visit.

Cited by 16 publications

References 34 publications

Associations of lipid levels during gestation with hypertensive disorders of pregnancy and gestational diabetes mellitus: a prospective longitudinal cohort study

Associations of lipid levels during gestation with hypertensive disorders of pregnancy and gestational diabetes mellitus: a prospective longitudinal cohort study

Metabolic syndrome in pregnancy and postpartum: prevalence and associated factors

Prevalence of gestational diabetes mellitus in a Suburban District in Sri Lanka: a population based study

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