Predicting the Emergence of Preclinical Mental Disorders to Combatants

Ичитовкина, Е Г; Злоказова, М. В.; Soloviev, A. G.; Соловьев, А. Г.; Kharkova, O A; Shutko, G V

doi:10.33396/1728-0869-2016-10-47-50

Cited by 4 publications

(1 citation statement)

References 2 publications

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“…Two of these equilibria would then represent healthy and diseased conditions, the others would be interpreted as prenosological states. Mental disorders in combatants for example can be preceded by milder neurotic conditions [65] . In this case, changes to

could induce direct transitions between healthy and diseased states, but could also modulate a first passage from the healthy to the prenosological state, and then from the prenosological to the diseased state.…”

Section: Reduced Model Without Circadian Drivementioning

confidence: 99%

Mathematical modeling of depressive disorders: Circadian driving, bistability and dynamical transitions

Cheng

D’Orsogna

Chou

2021

Computational and Structural Biotechnology Journal

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The hypothalamus–pituitary–adrenal (HPA) axis is a key neuroendocrine system implicated in stress response, major depression disorder, and post-traumatic stress disorder. We present a new, compact dynamical systems model for the response of the HPA axis to external stimuli, representing stressors or therapeutic intervention, in the presence of a circadian input. Our work builds upon previous HPA axis models where hormonal dynamics are separated into slow and fast components. Several simplifications allow us to derive an effective model of two equations, similar to a multiplicative-input FitzHugh-Nagumo system, where two stable states, a healthy and a diseased one, arise. We analyze the effective model in the context of state transitions driven by external shocks to the hypothalamus, but also modulated by circadian rhythms. Our analyses provide mechanistic insight into the effects of the circadian cycle on input driven transitions of the HPA axis and suggest a circadian influence on exposure or cognitive behavioral therapy in depression, or post-traumatic stress disorder treatment.

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Section: Reduced Model Without Circadian Drivementioning

confidence: 99%

Mathematical modeling of depressive disorders: Circadian driving, bistability and dynamical transitions

Cheng

D’Orsogna

Chou

2021

Computational and Structural Biotechnology Journal

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Predicting the Emergence of Preclinical Mental Disorders to Combatants

Ичитовкина

Злоказова

Soloviev

et al. 2016

Ekologiya cheloveka (Human Ecology)

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Nozologically formed borderline mental disorder (BMD) in combatants have a lower prevalence of mental disorders unlike a painful level. Blurred diagnostic criteria do not allow to attribute to the category of BMD the short-term outage of disturbance of mental adaptation - transient affective and behavioral reactions (TABR). In order to develop the expectancy model of TABR formation an analysis of personality characteristics of 649 combatants of the Interior Ministry have been carried out. Intermittent TABR in anamnesis revealed in 311 persons, such states and other violations of mental adaptation was not recorded in 338. Four years later, after the trip to zones with special service conditions, according to the I. Kotenev's method and Bass-Dark's test combatants revealed signs of maladjustment and high levels of physical aggression. Based on the data the TABR model has been designed using logistic regression and method of forced variables input. It was found that the risk of TABR formation increases with a decrease in the indicator "the invasion of the symptoms" scale and by increasing the parameters in the scale of "hyperactivity symptoms," "distress and maladjustment," "signs of post traumatic stress disorder" "physical aggression" and "verbal aggression". This shows that TABR more often appear in combatants with increased excitability in everyday life and a high level of physical aggression, while the symptoms of re-experiencing the traumatic event are not the triggering factor of TABR formation. This technique was proposed to use in medical and psychological support of personnel to prevent formation of TABR in combatants.

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Individual Psychological Predictors of the Adaptation and Disadaptation Among Specialists of Extreme Profile

Rybnikov

Dubinsky

Булыгина

2017

Ekologiya cheloveka (Human Ecology)

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The study results of individual and psychological predictors of adaptation and disadaptation in specialists of extreme profile are presented. The main group included 65 males - law enforcement agencies (Federal Service for the Execution of Sentences and the Ministry of Interior). The experimental group included 70 males, whose professional activity lied outside the extreme and emergency situations. Diagnostic complex included the following questionnaires: the formal and dynamic properties of individuality by V.M. Rusalov; temperament character by G. Eysenk; inventory of anxiousness by C.D. Spealberger; «The style of self-regulation» by V.I. Morosanova; aggression questionnaire by Buss - Perry, self-control questionnaire by Grasmic. It was found that the specialists of extreme profile were characterizes by higher rates of short-stopping behavior, psychomotor and communication tolerance and flexibility, psychomotor and intellectual speed, indexes of general activity and adaptability, extroversion, general level of self-regulation and the stages of self-regulation process, physical activity, physical assault , and lower rates of psychomotor, communicative and intellectual emotionality, state and personal anxiety, neuroticism, preferences for simple tasks and hostility. Based on the identified variable predictors associated with the length of service, 2 clusters were identified classifying the cases of high and low adaptability. The results of the analysis of significant differences in the selected clusters allowed determining significant adaptedness conditions. They are: higher indices of short-stopping behavior, psychomotor and communication tolerance, psychomotor, intellectual, communicative flexibility and physical activity speed. Less «adaptive» cluster was characterized by higher indices of psychomotor, intellectual, communicative emotionality, neuroticism, state and personal anxiety, and preferences of simple tasks. The predictive classification models of extreme profile specialists' adaptation were constructed. They included variable predictors: flexibility, communication tolerance, psychomotor, intellectual, communicative flexibility, psychomotor speed and total adaptability index.

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Predicting the Emergence of Preclinical Mental Disorders to Combatants

Cited by 4 publications

References 2 publications

Mathematical modeling of depressive disorders: Circadian driving, bistability and dynamical transitions

Mathematical modeling of depressive disorders: Circadian driving, bistability and dynamical transitions

Predicting the Emergence of Preclinical Mental Disorders to Combatants

Individual Psychological Predictors of the Adaptation and Disadaptation Among Specialists of Extreme Profile

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