Predictable maternal separation confers adult stress resilience via the medial prefrontal cortex oxytocin signaling pathway in rats

Shi, Dongdong; Zhang, Ying-Dan; Ren, Yanru; Peng, Shi-Yu; Yuan, Ti‐Fei; Wang, Zhen

doi:10.1038/s41380-021-01293-w

Cited by 35 publications

(34 citation statements)

References 47 publications

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“…Oxytocin has also been shown to be involved in the effects of early life stress. Oxytocin signaling in the medial prefrontal cortex has been reported to promote stress resilience in response to exposure to predictable maternal separation, while reduction in the expression of the oxytocin receptor has been shown to induce stress susceptibility in response to exposure to unpredictable maternal separation stress [ 172 ]. Early-life adversity has been shown to influence vulnerability to drug abuse by weakening oxytocin systems [ 173 ].…”

Section: Resilience and Oxytocinmentioning

confidence: 99%

Roles of Oxytocin in Stress Responses, Allostasis and Resilience

Takayanagi

Onaka

2021

IJMS

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Oxytocin has been revealed to work for anxiety suppression and anti-stress as well as for psychosocial behavior and reproductive functions. Oxytocin neurons are activated by various stressful stimuli. The oxytocin receptor is widely distributed within the brain, and oxytocin that is released or diffused affects behavioral and neuroendocrine stress responses. On the other hand, there has been an increasing number of reports on the role of oxytocin in allostasis and resilience. It has been shown that oxytocin maintains homeostasis, shifts the set point for adaptation to a changing environment (allostasis) and contributes to recovery from the shifted set point by inducing active coping responses to stressful stimuli (resilience). Recent studies have suggested that oxytocin is also involved in stress-related disorders, and it has been shown in clinical trials that oxytocin provides therapeutic benefits for patients diagnosed with stress-related disorders. This review includes the latest information on the role of oxytocin in stress responses and adaptation.

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Section: Resilience and Oxytocinmentioning

confidence: 99%

Roles of Oxytocin in Stress Responses, Allostasis and Resilience

Takayanagi

Onaka

2021

IJMS

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“…Importantly, some mild stressors at this developmental stage, such as brief maternal separation that mimics mother leaving to search for food, might induce subsequent stress tolerance and improved coping responses toward future stressors ( Papaioannou et al, 2002 ; Plotsky et al, 2005 ; Oomen et al, 2010 ; Russo et al, 2012 ). Recent findings indicate that predictable neonatal stress induces pro-resilience, whereas unpredictable neonatal stress induces pro-susceptibility ( Shi et al, 2021 ). Consistently human adolescents who experienced mild childhood adversity also exhibit better stress coping ( Shapero et al, 2015 ).…”

Section: Modelling Pathogenesismentioning

confidence: 99%

“…Rearing in communal nests with a higher number of pups and mothers can confer resilience to social stress ( Branchi et al, 2013 ). The stress-buffering effects of milder predictable neonatal stress forms remain an important underexplored research venue ( Shi et al, 2021 ). Overall, the usefulness of neonatal paradigms consists of controllable environmental programming which allows for study of (1) interactions between genetic and environmental vulnerability factors, and (2) modulation of adulthood stress coping responses by the ELS ( Dich et al, 2015 ).…”

Section: Modelling Pathogenesismentioning

confidence: 99%

Encore: Behavioural animal models of stress, depression and mood disorders

Petković

Chaudhury

2022

Front. Behav. Neurosci.

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Animal studies over the past two decades have led to extensive advances in our understanding of pathogenesis of depressive and mood disorders. Among these, rodent behavioural models proved to be of highest informative value. Here, we present a comprehensive overview of the most popular behavioural models with respect to physiological, circuit, and molecular biological correlates. Behavioural stress paradigms and behavioural tests are assessed in terms of outcomes, strengths, weaknesses, and translational value, especially in the domain of pharmacological studies.

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“…A meta-analysis found that maternal stress exposure caused a prolonged glucocorticoid recovery and a delayed return to baseline in the offspring after a subsequent stress challenge [ 93 ]. Furthermore, depending on the stress paradigm, the maternal separation could promote resilience to subsequent stressors, which is a prime example of effective allostatic adaptation [ 94 ]. In contrast, Pena et al demonstrated that maternal separation led to a susceptibility to social defeat stress, which is a stress paradigm in adults [ 95 ].…”

Section: Developmental Stressors’ Impact On Brain Microgliamentioning

confidence: 99%

Developmental Stressors Induce Innate Immune Memory in Microglia and Contribute to Disease Risk

Carloni

Ramos

Hayes

2021

IJMS

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Many types of stressors have an impact on brain development, function, and disease susceptibility including immune stressors, psychosocial stressors, and exposure to drugs of abuse. We propose that these diverse developmental stressors may utilize a common mechanism that underlies impaired cognitive function and neurodevelopmental disorders such as schizophrenia, autism, and mood disorders that can develop in later life as a result of developmental stressors. While these stressors are directed at critical developmental windows, their impacts are long-lasting. Immune activation is a shared pathophysiology across several different developmental stressors and may thus be a targetable treatment to mitigate the later behavioral deficits. In this review, we explore different types of prenatal and perinatal stressors and their contribution to disease risk and underlying molecular mechanisms. We highlight the impact of developmental stressors on microglia biology because of their early infiltration into the brain, their critical role in brain development and function, and their long-lived status in the brain throughout life. Furthermore, we introduce innate immune memory as a potential underlying mechanism for developmental stressors’ impact on disease. Finally, we highlight the molecular and epigenetic reprogramming that is known to underlie innate immune memory and explain how similar molecular mechanisms may be at work for cells to retain a long-term perturbation after exposure to developmental stressors.

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Predictable maternal separation confers adult stress resilience via the medial prefrontal cortex oxytocin signaling pathway in rats

Cited by 35 publications

References 47 publications

Roles of Oxytocin in Stress Responses, Allostasis and Resilience

Roles of Oxytocin in Stress Responses, Allostasis and Resilience

Encore: Behavioural animal models of stress, depression and mood disorders

Developmental Stressors Induce Innate Immune Memory in Microglia and Contribute to Disease Risk

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