Roles of Oxytocin in Stress Responses, Allostasis and Resilience

Takayanagi, Yuki; Onaka, Tatsushi

doi:10.3390/ijms23010150

Cited by 56 publications

(54 citation statements)

References 233 publications

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“…The promoting effects of stress on social interaction were observed in WT mice of both sexes and may be explained by multiple hypotheses. One possible explanation lies in the prosocial effects of increased oxytocin, since this has been described in hypothalamic and limbic brain regions following exposure to a variety of stressors 63 . A second possible interpretation may consider the increased social interaction of WT stressed mice as a reflection of a the altered excitatory/inhibitory(E/I) imbalance induced by stress especially in brain circuits involving the prefrontal cortex 15 , 64 , known to critically control social behaviors in rodents 65 , 66 .…”

Section: Discussionmentioning

confidence: 99%

Autistic-like behavioral effects of prenatal stress in juvenile Fmr1 mice: the relevance of sex differences and gene–environment interactions

Petroni

Subashi

Premoli

et al. 2022

Sci Rep

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Fragile X Syndrome (FXS) is the most common heritable form of mental retardation and monogenic cause of autism spectrum disorder (ASD). FXS is due to a mutation in the X-linked FMR1 gene and is characterized by motor, cognitive and social alterations, mostly overlapping with ASD behavioral phenotypes. The severity of these symptoms and their timing may be exacerbated and/or advanced by environmental adversity interacting with the genetic mutation. We therefore tested the effects of the prenatal exposure to unpredictable chronic stress on the behavioral phenotype of juveniles of both sexes in the Fmr1 knock-out (KO) mouse model of FXS. Mice underwent behavioral tests at 7–8 weeks of age, that is, when most of the relevant behavioral alterations are absent or mild in Fmr1-KOs. Stress induced the early appearance of deficits in spontaneous alternation in KO male mice, without exacerbating the behavioral phenotype of mutant females. In males stress also altered social interaction and communication, but mostly in WT mice, while in females it induced effects on locomotion and communication in mice of both genotypes. Our data therefore highlight the sex-dependent relevance of early environmental stressors to interact with genetic factors to influence the appearance of selected FXS- and ASD-like phenotypes.

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Section: Discussionmentioning

confidence: 99%

Autistic-like behavioral effects of prenatal stress in juvenile Fmr1 mice: the relevance of sex differences and gene–environment interactions

Petroni

Subashi

Premoli

et al. 2022

Sci Rep

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show abstract

“…Moreover, it has been suggested that the role of oxytocin is best characterised through allostasis; as it can help facilitate the dynamic adjustment and consolidation of homoeostatic setpoints, and is crucial to many of life’s essential survival needs ( Quintana and Guastella, 2020 ). Therefore, the effective activation of the oxytocin system could help achieve positive physical and psychological clinical results through its ability to help patients adapt and encourage successful recovery ( Takayanagi and Onaka, 2021 ). Additionally, oxytocin can help with analgesia due to its connection with decreased activity in the AIC in response to noxious stimuli, regulation of noxious threats, and increased activity in the prefrontal lobe ( Kreuder et al, 2019 ).…”

Section: The Role Of Touch In Developing a Connectionmentioning

confidence: 99%

Therapeutic Alliance as Active Inference: The Role of Therapeutic Touch and Biobehavioural Synchrony in Musculoskeletal Care

McParlin¹,

Cerritelli²,

Rossettini³

et al. 2022

Front. Behav. Neurosci.

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Touch is recognised as crucial for survival, fostering cooperative communication, accelerating recovery, reducing hospital stays, and promoting overall wellness and the therapeutic alliance. In this hypothesis and theory paper, we present an entwined model that combines touch for alignment and active inference to explain how the brain develops “priors” necessary for the health care provider to engage with the patient effectively. We appeal to active inference to explain the empirically integrative neurophysiological and behavioural mechanisms that underwrite synchronous relationships through touch. Specifically, we offer a formal framework for understanding – and explaining – the role of therapeutic touch and hands-on care in developing a therapeutic alliance and synchrony between health care providers and their patients in musculoskeletal care. We first review the crucial importance of therapeutic touch and its clinical role in facilitating the formation of a solid therapeutic alliance and in regulating allostasis. We then consider how touch is used clinically – to promote cooperative communication, demonstrate empathy, overcome uncertainty, and infer the mental states of others – through the lens of active inference. We conclude that touch plays a crucial role in achieving successful clinical outcomes and adapting previous priors to create intertwined beliefs. The ensuing framework may help healthcare providers in the field of musculoskeletal care to use hands-on care to strengthen the therapeutic alliance, minimise prediction errors (a.k.a., free energy), and thereby promote recovery from physical and psychological impairments.

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“…Thus, stimuli that can be interpreted by the subject as potentially dangerous, such as the presence of a stranger or a person with traits that suggest mistrust, or a hostile environment, will trigger a completely different oxytocin-mediated reaction compared to the presence of either a very close person or positive facial expressions that indicate a friendly environment. The fact that oxytocin can cause different reactions depending on how the environment is perceived by the subject is based on the hypothesis that oxytocin plays its role indirectly, orchestrating the activity of several neurotransmitter systems [ 38 , 39 ].…”

Section: Connections Between Oxytocin and Neurotransmitters In Affect...mentioning

confidence: 99%

Oxytocin: Narrative Expert Review of Current Perspectives on the Relationship with Other Neurotransmitters and the Impact on the Main Psychiatric Disorders

et al. 2022

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Is a cyclic neuropeptide produced primarily in the hypothalamus and plays an important neuromodulatory role for other neurotransmitter systems, with an impact on behavior, response to danger, stress, and complex social interactions, such as pair bonding and child care. This narrative expert review examines the literature on oxytocin as a brain hormone. We focused on oxytocin structure, distribution, genetics, and the oxytocin receptor system, as well as the relationship of oxytocin with other neurotransmitters and the resulting impacts on the main psychiatric disorders. Oxytocin levels have been correlated over time with mental illness, with numerous studies focusing on oxytocin and the pathophysiology of the main psychiatric disorders, such as autism, schizophrenia, personality disorders, mood, and eating disorders. We highlight the role oxytocin plays in improving symptoms such as anxiety, depression, and social behavior, as the literature suggests. Risk factors and causes for psychiatric disorders range from genetic to environmental and social factors. Oxytocin could impact the latter, being linked with other neurotransmitter systems that are responsible for integrating different situations during the development phases of individuals. Also, these systems have an important role in how the body responds to stressors or bonding with others, helping with the creation of social support groups that could speed up recovery in many situations. Oxytocin has the potential to become a key therapeutic agent for future treatment and prevention strategies concerning the main psychiatric disorders.

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Roles of Oxytocin in Stress Responses, Allostasis and Resilience

Cited by 56 publications

References 233 publications

Autistic-like behavioral effects of prenatal stress in juvenile Fmr1 mice: the relevance of sex differences and gene–environment interactions

Autistic-like behavioral effects of prenatal stress in juvenile Fmr1 mice: the relevance of sex differences and gene–environment interactions

Therapeutic Alliance as Active Inference: The Role of Therapeutic Touch and Biobehavioural Synchrony in Musculoskeletal Care

Oxytocin: Narrative Expert Review of Current Perspectives on the Relationship with Other Neurotransmitters and the Impact on the Main Psychiatric Disorders

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