Prediabetes: Why Should We Care?

Zand, Ashkan; Ibrahim, Karim; Patham, Bhargavi

doi:10.14797/mdcj-14-4-289

Cited by 69 publications

(31 citation statements)

References 37 publications

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“…A systematic review by the U.S. Preventive Services Task Force (USPSTF) reported that the treatment of IFG is associated with delayed progression to DM [ 27 ]. Therefore, it is necessary to prevent progression to DM in subjects with IFG by applying the appropriate lifestyle and medical interventions [ 2 ]. In particular, subjects with IFG are at higher risk of developing cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

“…Prediabetes is defined when the glucose levels do not meet the criteria for DM but are too high to be considered normal, including impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) [ 2 ]. Among them, IFG is diagnosed when the blood glucose levels are between 100 and 125 mg/dL (5.6 to 7.0 mmol/L), and it is highly associated with the development of DM [ 2 ]. IFG increases the risk of progression to DM, and the annual rate of conversion to DM is 6–9% [ 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

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Incidence and Risk Factors for Progression to Diabetes Mellitus: A Retrospective Cohort Study

Hyun

Park

Kim

et al. 2021

IJERPH

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(1) Objective: This study examined the incidence and risk factors contributing to the progression to diabetes mellitus (DM) in a seven-year follow-up study of non-diabetic National Health Examinees. (2) Methods: For this retrospective observational cohort study, we used two national representative databases: the National Health Screening (HEALS) database 2009 and the National Health Insurance Service (NHIS) database 2009–2015. The eligible subjects without DM with blood sugar levels of <126 mg/dL were selected using the HEALS database. The subsequent follow-up and clinical outcomes were evaluated using the NHIS database. Cox proportional hazard regression was applied to examine the effects of the covariates on progression to diabetes. (3) Results: Among those who took part in the national health screening in 2009, 4,205,006 subjects who met the eligibility criteria were selected. Of these, 587,015 were diagnosed with DM during the follow-up by 2015. The incidence of progression from non-diabetes to DM was 14.0%, whereas that from impaired fasting glucose (IFG) to DM was 21.9%. Compared to the normal group, the newly diagnosed DM group was more likely to comprise older, female, currently smoking, and high-risk drinking participants and participants with IFG, hypertension, dyslipidemia, and metabolic syndrome. (4) Conclusions: This epidemiological study in the Republic of Korea found risk factors similar to those of other studies, but the incidence of progression to DM was 22.8 per 1000 person-years, which is higher than that previously reported. Hence, more care is needed to prevent DM.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incidence and Risk Factors for Progression to Diabetes Mellitus: A Retrospective Cohort Study

Hyun

Park

Kim

et al. 2021

IJERPH

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“…The experimental model of impaired glucose tolerance induced by dexamethasone was characterized by an excessive increase in the level of glycemia after carbohydrate loading and indicated the development of prediabetes due to the formation of insulin resistance and secondary or primary dysfunction of β-cells [18,19].…”

Section: Discussionmentioning

confidence: 99%

Screening study of the antihyperglycemic action of new solid quercetin dispersions

Рубан

Кононенко

Kovalevska

et al. 2021

SR: PS

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The aim – to screen new solid dispersions of quercetin for the presence of antihyperglycemic action and to identify the most active substances that are promising for the creation of antidiabetic drugs. Materials and methods. The object of the study was 4 new solid dispersions of quercetin, developed at the National University of Pharmacy. Solid dispersions of quercetin were prepared by the liquid-phase method; hydroxypropyl methylcellulose (HPMC) or polyvinylpyrrolidone (PVP) in ratios of 1:1 and 1:2 were used as a carrier. The antihyperglycemic effect of the studied substances at a dose of 50 mg / kg was assessed in rats by the ability to lower blood glucose levels after carbohydrate loading in a model of impaired glucose tolerance induced by dexamethasone and in experimental type 2 diabetes mellitus induced by dexamethasone. Results. It was found that with impaired glucose tolerance, a solid dispersion of quercetin with HPMC (1:1) showed a pronounced antihyperglycemic effect – the glucose level 30 minutes after glucose load significantly decreased by 28 % and did not differ from the action of metformin, which was confirmed by the value of the area under glycemic crooked. When solid dispersions with PVP (1:1 and 1:2) were used, the antihyperglycemic effect was less pronounced. In a model of type 2 diabetes mellitus, a significant antihyperglycemic effect was found only in a solid dispersion of quercetin with HPMC (1:1) at the metformin level, which indicates an increase in the solubility and absorption of quercetin. Conclusions. A pronounced antihyperglycemic effect at the metformin level was found in a solid dispersion of quercetin with HPMC in a 1:1 ratio with impaired glucose tolerance and type 2 diabetes mellitus. It has been proven that a solid dispersion of quercetin with HPMC is a promising substance for creating a monocomponent drug or for inclusion in a new antidiabetic combined drug

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“…Prevalence of prediabetes is increasing worldwide and more than 470 million people will have prediabetes by 2030 ( 2 ). Previous studies indicated that prediabetes was associated with an increased risk of coronary heart disease, stroke, and all-cause mortality ( 3 ). Meanwhile, it is estimated that the number of patients with diabetes were expected to increase to 693 million by 2045.…”

Section: Introductionmentioning

confidence: 99%

Identification of Key LncRNAs and Pathways in Prediabetes and Type 2 Diabetes Mellitus for Hypertriglyceridemia Patients Based on Weighted Gene Co-Expression Network Analysis

et al. 2022

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AimsPrevalence of prediabetes and type 2 diabetes mellitus(T2DM) are increasing worldwide. Key lncRNAs were detected to provide a reference for searching potential biomarkers of prediabetes and T2DM in hypertriglyceridemia patients.MethodsThe study included 18 hypertriglyceridemia patients: 6 newly diagnosed type 2 diabetes patients, 6 samples with prediabetes and 6 samples with normal blood glucose. Weighted gene co-expression network analysis (WGCNA) was conducted to construct co‐expression network and obtain modules related to blood glucose, thus detecting key lncRNAs.ResultsThe green, yellow and yellow module was significantly related to blood glucose in T2DM versus normal controls, T2DM versus prediabetes, prediabetes versus normal controls, respectively. ENST00000503273, ENST00000462720, ENST00000480633 and ENST00000485392 were detected as key lncRNAs for the above three groups, respectively.ConclusionsFor hypertriglyceridemia patients with different blood glucose levels, ENST00000503273, ENST00000462720 and ENST00000480633 could be potential biomarkers of T2DM.

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Prediabetes: Why Should We Care?

Cited by 69 publications

References 37 publications

Incidence and Risk Factors for Progression to Diabetes Mellitus: A Retrospective Cohort Study

Incidence and Risk Factors for Progression to Diabetes Mellitus: A Retrospective Cohort Study

Screening study of the antihyperglycemic action of new solid quercetin dispersions

Identification of Key LncRNAs and Pathways in Prediabetes and Type 2 Diabetes Mellitus for Hypertriglyceridemia Patients Based on Weighted Gene Co-Expression Network Analysis

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