Prediabetes

Jackson, W. P. U.

doi:10.1136/pgmj.35.403.287

Cited by 24 publications

(2 citation statements)

References 28 publications

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“…JACKSO~ [3] has defined "prediabetes" as "the state of a person during the period before he or she becomes plainly and clinically diabetic, in which, however, there is a latent abnormality which may show itself under certain specific conditions". At a concentration of 1.25%, albumin from obese diabetics and prediabeties is antagonistic to insulin to the same extent as albumin prepared from the plasma of insulin-requiring diabetic patients, and to a considerably greater extent than normal albmnin which is inactive at this concentration [16].…”

Section: Der Vererbung Des Essentiellen Diabetes Mellitus Aufmentioning

confidence: 99%

The inheritance of essential diabetes mellitus from studies of the synalbumin insulin antagonist

Vallance‐Owen

1966

Diabetologia

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Summary. Patients with essential diabetes including prediabetes have more synalbumin antagonism to insulin than normal subjects or patients with "pancreatic" diabetes, e.g. after panereatectomy. Thus excessive synalburain antagonism (synalbumin positive) can be regarded as a biochemical marker to ascertain whether a given person is constituted as an essential diabetic --without reference to carbohydrate intolerance. --On this premise, the genetic transmission of essential diabetes has been examined by studying the relatives of essential diabetics. The results strongly suggest that excessive synalbumin antagonism is inherited as an autosomal "dominant" character. --Ninety-seven members of nine families were studied, 39 were synalbumin negative whereas 58 were synalbumin positive, but only 16 of these latter have overt carbohydrate intolerance. A further three have spontaneous hypoglycaemia whereas the remainder are quite asymptomatic. These observations suggest that overt carbohydrate intolerance is relatively uncommon or will be a late event in many people constituted as essential diabetics.L'hdrdditd du diab~te sucr5 essentiel d'apr@s des gtudes de l'antagoniste synalbuminique de l'insuline.Rgsumg. Les patients atteints de diab@te essentiel, y compris les pr6diab6tiques, ont davantage d'antagonisme synalbuminique vis-a-vis de l'insuline que les sujets normaux ou les patients atteints de diab~te ((pancr@atique)) c-~-d, apr@s pancr6atectomie. L'antagonisme synalbuminiclue excessif (synalbumine positif) peut done @tre consid6r6 comme un crit~re biochimique pour d6terminer si une personne donnde a une constitution de diab6tique essentiel --sans se r6f6rer ~ l'intol6rance aux hydrates de carbone. --A partir de ceci, la transmission g6ndtique du diab~te essentiel a 6t6 examin6e par l'dtude des parents des diab6tiques essentiels. Les r6sultats sugg~rent fortement que l'antagonisme synalbuminique excessif se transmet comme un caract~re autosomial ((dominant)~. --Quatre-vingt-dix-sept membres appartenant ~ neuf faraffles ont gt6 6tudi6s, 39 gtaient synalbumine nggatif, tandis que 58 gtaient synalbumine positif, mais seulement 16 de ces derniers avaient une intolgrance manifeste aux hydrates de carbone. Trois autres avaient une hypoglyc6mie spontan6e, tandis que les autres 6talent compl@te-ment asymptomatiques. Ces observations sugg@rent que l'intolgrance manifeste aux hydrates de earbone est relativement peu fr6quente, ou qu'elle sera un 6v~nement tardif chez beaucoup de personnes ayant la constitution de diab6tiques essentiels. It has long been reeognised that there is a higher incidence of diabetes mellitus among the relatives of diabetics than among the rest of the population. Nevertheless, there is apparently considerable confusion regarding the mode of inheritance of this condition. After reviewing much of the available evidence ~:)I~CUs and WHITE [7] and STEI~E~O [8,9] conclude that predisposition to diabetes is probably due to homozygosis for a recessive gene; although a number of investigators hold different vie...

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Section: Der Vererbung Des Essentiellen Diabetes Mellitus Aufmentioning

confidence: 99%

The inheritance of essential diabetes mellitus from studies of the synalbumin insulin antagonist

Vallance‐Owen

1966

Diabetologia

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“…This concept of stress has been further extended with the introduction of the cortisone-glucose tolerance test [11]. Although such tests have been of considerable use in the definition of most diabetic states, they often fail to define adequately the presence of early diabetes, particularly in pregnancy [17]. Further, until the advent of insulin immunoassay and the demonstration of "delayed" insulin responses in maturity-onset diabetes [7,26] with the attendant extension of the "quantitative" and "qualitative" insulin deficiency concepts to include a "dynamic" anomaly, the use of such tests has not materially assisted in furthering insight into the aetiology of diabetes.…”

Section: Introductionmentioning

confidence: 99%

The response to intravenous glucose infusion in normal and diabetic subjects

et al. 1970

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Data from single injection studies on 23 normal subjects led to development of an intravenous primed-constant infusion test. The plasma glucose response to this test was determined in 48 normal and 24 diabetic subjects. Variation in plasma glucose concentration at equilibrium was minimal in normal and marked in diabetic subjects-assessed by the difference between maximum and minimum glucose concentration over the final 25 rain of a 50 min infusion. This parameter was used successfully in predicting the course of 16 pregnant women with clinical suspicion of prediabetes unresolved by oral glucose tolerance tests. R@onse ~t l'infusion intraveineuse de glucose chez les sujets normaux et diabdtiques R~sumd. L'6tude des rdsultats obtenus lors d'une injection intraveineuse unique de glucose chez vingt-trois sujets normaux a conduit N la raise au point d'une technique de perfusion constante pr6cddge d'une injection rapide. Ce test a 6t6 pratiqu~ chez 48 sujets normaux et 24 sujets diab6tiques. La difference entre les concentrations maximale et minimale du glucose sanguin observ~es au tours des 25 derni~res minutes du test a 6tg minime chez les sujets normaux, 61ev6e chez les sujets diab6tiques. Ce paramgtre a permis de prgdire l'6volution clini-clue de 16 femmes enceintes suspectes de prddiab~te non dgtermin6 lors de tests de toldrance au glucose effectu~s par voie orale. Die Reaktion auf intraven6se Glucoseinfusion bei normatch und diabetisehen Probanden Zusammenfassung. Die Ergebnisse yon Einmalinjektions-Versuchen bei 23 normalen Versuehspersonen fiihrten zur Entwicklung eines aus Stol?-und Dauerinfusion kombinierten Tests. Das Verhalten der Plasma-Glucosespiegel wiihrend dieser Belastung wurde bei 48 Stoffwechselgesunden und 24 Diabetikern iiberpriift. Die Sehwankungen der Plasma-Glucosekonzentrationen im Gleiehgewichtszustand wurden an Hand der Differenz zwischen maximalen und minimalen Glucosespiegeln w/~hrend der letzten 25 rain einer 50 rain dauernden Infusionsperiode beurteilt. Sie fielen bei Normalpersonen minimal, bei Diabetikern hingegen deutlich aus. Dieser Parameter konnte erfolgreich zur Voraussage des Verlaufs bei 16 Schwangeren mit klinischem Verdacht auf Pr/idiabetes herangezogen werden, der durch die orale Glucosebelastung nieht abgekl/~rt werden konnte.

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Body Weight and Subsequent Diabetes Mellitus

O’Sullivan¹

1982

JAMA

159

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Prediabetes

Cited by 24 publications

References 28 publications

The inheritance of essential diabetes mellitus from studies of the synalbumin insulin antagonist

The inheritance of essential diabetes mellitus from studies of the synalbumin insulin antagonist

The response to intravenous glucose infusion in normal and diabetic subjects

Body Weight and Subsequent Diabetes Mellitus

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