“…O'Sullivan originally projected that 50% of patients with GDM would develop diabetes in a follow-up study of 22-28 years. 5 The progression to type 2 DM may be influenced by ethnicity and the profound increased incidence of obesity in the U.S. population in recent years. For example, 60% of Latina women with GDM will develop type 2 DM, and this level of risk may actually be manifest by 5 years after the GDM index pregnancy.…”
Section: Screening and Diagnosismentioning
confidence: 99%
“…69 O'Sullivan's original cohort of women with former GDM indicated a prevalence of diabetes of 50 -60% at 28 years of follow-up. 5 70 Abnormal carbohydrate intolerance may persist in the postpartum period depending on the population studied and its associated risk factors. As many as one-third of women with GDM will have overt diabetes, impaired fasting glucose, or impaired glucose tolerance identified during postpartum testing conducted within 6 -12 weeks of delivery.…”
Section: Postpartum Follow-up and Prevention Of Type 2 Diabetesmentioning
Gestational diabetes mellitus (GDM) represents a heterogeneous group of metabolic disorders, which result in varying degrees of maternal hyperglycemia and pregnancy-associated risk. The frequency of GDM is rising globally and may also increase further as less-stringent criteria for the diagnosis are potentially adopted. The additional burden placed on the health care system by increasing cases of GDM requires consideration of diagnostic approaches and currently used treatment strategies. Debate continues to surround both the diagnosis and treatment of GDM despite several recent large-scale studies addressing these controversial issues. As many now have come to reassess their approach to the management of GDM, we provide information in this review to help guide this process. The goal for each health care practitioner should continue to be to provide optimum care for women discovered to have carbohydrate intolerance during pregnancy.
“…O'Sullivan originally projected that 50% of patients with GDM would develop diabetes in a follow-up study of 22-28 years. 5 The progression to type 2 DM may be influenced by ethnicity and the profound increased incidence of obesity in the U.S. population in recent years. For example, 60% of Latina women with GDM will develop type 2 DM, and this level of risk may actually be manifest by 5 years after the GDM index pregnancy.…”
Section: Screening and Diagnosismentioning
confidence: 99%
“…69 O'Sullivan's original cohort of women with former GDM indicated a prevalence of diabetes of 50 -60% at 28 years of follow-up. 5 70 Abnormal carbohydrate intolerance may persist in the postpartum period depending on the population studied and its associated risk factors. As many as one-third of women with GDM will have overt diabetes, impaired fasting glucose, or impaired glucose tolerance identified during postpartum testing conducted within 6 -12 weeks of delivery.…”
Section: Postpartum Follow-up and Prevention Of Type 2 Diabetesmentioning
Gestational diabetes mellitus (GDM) represents a heterogeneous group of metabolic disorders, which result in varying degrees of maternal hyperglycemia and pregnancy-associated risk. The frequency of GDM is rising globally and may also increase further as less-stringent criteria for the diagnosis are potentially adopted. The additional burden placed on the health care system by increasing cases of GDM requires consideration of diagnostic approaches and currently used treatment strategies. Debate continues to surround both the diagnosis and treatment of GDM despite several recent large-scale studies addressing these controversial issues. As many now have come to reassess their approach to the management of GDM, we provide information in this review to help guide this process. The goal for each health care practitioner should continue to be to provide optimum care for women discovered to have carbohydrate intolerance during pregnancy.
“…11,12 Furthermore, it has been long known that women with a history of gestational diabetes, as compared with their counterparts without such a reproductive history, are at increased risk of developing type 2 diabetes overall. 13,14 In a case-control study of 67 women with gestational diabetes and 260 controls, we observed that maternal intrapartum plasma ascorbic acid concentrations were 31% lower for cases than controls on average (mean Ϯ standard error ϭ 36.5 Ϯ 2.0 vs. 53.0 Ϯ 1.0 mol/L). We also found that women with plasma ascorbic acid concentrations below 42.6 mol/L experienced a 13-fold (95% CI ϭ 3.5-46.2) increased risk of gestational diabetes as compared with women with values above 63.3 mol/L.…”
If confirmed, our results raise the possibility that current efforts to encourage populations to consume diets rich in antioxidants, including vitamin C, could reduce the occurrence of gestational diabetes mellitus.
“…However, women who are obese during pregnancy and develop gestational diabetes have been shown to have a 2-fold increased prevalence of subsequent type 2 diabetes as compared to lean women. 27 Therefore, maternal obesity is a significant long-term risk factor for type 2 diabetes. 28 The association between obesity and hypertensive disorders during pregnancy has been a consistent finding in the obstetrical literature (Table 2).…”
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