Prediabetes: a position statement from the Australian Diabetes Society and Australian Diabetes Educators Association

Twigg, Stephen M.; Kamp, Maarten C; Davis, Timothy; Neylon, Elizabeth K; Flack, J.

doi:10.5694/j.1326-5377.2007.tb00998.x

Cited by 108 publications

(75 citation statements)

References 45 publications

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“…The Indian Health Services guidelines also encourage lifestyle changes with consideration for metformin on an individualized basis (32). The Australian guidelines recommend lifestyle intervention as first-line therapy for a minimum of 6 months before consideration of pharmacotherapy (33). A recent study in the US demonstrated that more than 96% of individuals with both IFG and IGT would be eligible for metformin therapy according to the ADA consensus criteria (34).…”

Section: Current Guidelinesmentioning

confidence: 99%

Prediabetes as a Therapeutic Target

Pour

Dagogo‐Jack

2011

Clinical Chemistry

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BACKGROUND The term “prediabetes” is used to describe a condition that involves impaired glucose tolerance (IGT) or impaired fasting glucose (IFG). IGT is defined by a 2-h oral glucose tolerance test plasma glucose concentration >140 mg/dL (7.8 mmol/L) but <200 mg/dL (11.1 mmol/L), and IFG is defined by a fasting plasma glucose concentration ≥100 mg/dL (5.6 mmol/L), but <126 mg/dL (7.0 mmol/L). Studies have shown that people with prediabetes tend to develop type 2 diabetes within 10 years and are at increased risk for cardiovascular disease and death even before the development of diabetes. CONTENT In this minireview we discusses the epidemiology, pathophysiology, and clinical implications of prediabetes. The rationale for therapeutic intervention in people with prediabetes, the goals of intervention, and the specific tools for intervention are presented. Emphasis is placed on data from randomized controlled clinical trials, whenever such data are available. SUMMARY Approximately 57 million Americans have prediabetes and are consequently at risk for cardiometabolic complications. Lifestyle modifications (dietary restriction and exercise) and certain medications can prevent the development of diabetes in persons with prediabetes. Lifestyle intervention also has been demonstrated to decrease cardiovascular disease risk markers, although data on clinical events are lacking.

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Section: Current Guidelinesmentioning

confidence: 99%

Prediabetes as a Therapeutic Target

Pour

Dagogo‐Jack

2011

Clinical Chemistry

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“…Compared to individuals with normal glucose metabolism, patients with pre-DM have a five- to 15-fold higher risk of developing T2DM [21]. Likewise, few studies have focused on the relationship of chromium and pre-DM.…”

Section: Introductionmentioning

confidence: 99%

Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study

et al. 2017

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Chromium has long been known as an enhancer of insulin action. However, the role of chromium in the development of type 2 diabetes mellitus (T2DM) in humans remains controversial. The current study aimed to examine the associations of plasma chromium levels with T2DM and pre-diabetes mellitus (pre-DM). We conducted a case-control study involving 1471 patients with newly diagnosed T2DM, 682 individuals with newly diagnosed pre-DM, and 2290 individuals with normal glucose tolerance in a Chinese population from 2009 to 2014. Plasma chromium was measured by inductively coupled plasma mass spectrometry. Plasma chromium levels were lower in the T2DM and pre-DM groups than in the control group (median: 3.68 μg/L, 3.61 μg/L, 3.97 μg/L, respectively, p < 0.001). After adjustment for potential confounding factors, the odds ratios (95% confidence interval) for T2DM across increasing quartiles of plasma chromium levels were 1 (referent), 0.67 (0.55–0.83), 0.64 (0.51–0.79), and 0.58 (0.46–0.73), respectively (p for trend <0.001). The corresponding odds ratios (95% confidence interval) for pre-DM were 1 (referent), 0.70 (0.54–0.91), 0.67 (0.52–0.88), and 0.58 (0.43–0.78), respectively (p for trend < 0.001). Our results indicated that plasma chromium concentrations were inversely associated with T2DM and pre-DM in Chinese adults.

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“…Prediabetes is also especially prevalent among older adults [4,20]. Compared to individuals with normal glucose metabolism, patients with prediabetes have a 5–15-fold higher risk of developing type 2 diabetes [21]. However, prediabetes is a reversible state [22], and the identification of risk factors for this state is an important step for the early prevention of diabetes.…”

Section: Introductionmentioning

confidence: 99%

Associations of Serum Manganese Levels with Prediabetes and Diabetes among ≥60-Year-Old Chinese Adults: A Population-Based Cross-Sectional Analysis

et al. 2016

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Older adults can experience glucose metabolism dysfunction, and although manganese may help regulate glucose metabolism, there is little information regarding this association among older people. This cross-sectional study included 2402 Chinese adults who were ≥60 years old in 2013 (Tianjin, China), and evaluated the associations of serum manganese with prediabetes and diabetes. Serum manganese levels were measured using inductively coupled plasma mass spectrometry. Multivariable logistic regression models were used to evaluate the sex-specific associations of manganese levels with diabetes and prediabetes after adjusting for confounding factors (age, sex, life style factors, and health status). Based on the WHO criteria, prediabetes was observed in 15.1% of men and 13.4% of women, while diabetes was observed in 30.0% of men and 34.4% of women. In the final model, the odds ratios (95% confidence interval) for prediabetes according to manganese quartile were 1.000, 0.463 (0.269–0.798), 0.639 (0.383–1.065), and 0.614 (0.365–1.031) among men and 1.000, 0.773 (0.498–1.200), 0.602 (0.382–0.947), and 0.603 (0.381–0.953) among women (p for trend = 0.134 and 0.015, respectively). The lowest prevalence of diabetes among men occurred at a moderate range of serum manganese (p < 0.05). Therefore, appropriate serum manganese levels may help prevent and control prediabetes and diabetes.

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Prediabetes: a position statement from the Australian Diabetes Society and Australian Diabetes Educators Association

Cited by 108 publications

References 45 publications

Prediabetes as a Therapeutic Target

Prediabetes as a Therapeutic Target

Inverse Association of Plasma Chromium Levels with Newly Diagnosed Type 2 Diabetes: A Case-Control Study

Associations of Serum Manganese Levels with Prediabetes and Diabetes among ≥60-Year-Old Chinese Adults: A Population-Based Cross-Sectional Analysis

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