Associations of Serum Manganese Levels with Prediabetes and Diabetes among ≥60-Year-Old Chinese Adults: A Population-Based Cross-Sectional Analysis

Abstract

Older adults can experience glucose metabolism dysfunction, and although manganese may help regulate glucose metabolism, there is little information regarding this association among older people. This cross-sectional study included 2402 Chinese adults who were ≥60 years old in 2013 (Tianjin, China), and evaluated the associations of serum manganese with prediabetes and diabetes. Serum manganese levels were measured using inductively coupled plasma mass spectrometry. Multivariable logistic regression models were used to evaluate the sex-specific associations of manganese levels with diabetes and prediabetes after adjusting for confounding factors (age, sex, life style factors, and health status). Based on the WHO criteria, prediabetes was observed in 15.1% of men and 13.4% of women, while diabetes was observed in 30.0% of men and 34.4% of women. In the final model, the odds ratios (95% confidence interval) for prediabetes according to manganese quartile were 1.000, 0.463 (0.269–0.798), 0.639 (0.383–1.065), and 0.614 (0.365–1.031) among men and 1.000, 0.773 (0.498–1.200), 0.602 (0.382–0.947), and 0.603 (0.381–0.953) among women (p for trend = 0.134 and 0.015, respectively). The lowest prevalence of diabetes among men occurred at a moderate range of serum manganese (p < 0.05). Therefore, appropriate serum manganese levels may help prevent and control prediabetes and diabetes.

Micronutrient dietary patterns associated with type 2 diabetes mellitus among women of the E3N‐EPIC (Etude Epidémiologique auprès de femmes de l'Education Nationale) cohort study

“…36,37 Moreover the sixth pattern was correlated with the intake of chocolate, which is rich in manganese. Others have suggested that a high intake of manganese may have a protective effect, especially in people at high risk of developing T2DM.…”

“…Others have suggested that a high intake of manganese may have a protective effect, especially in people at high risk of developing T2DM. 36,37 Moreover the sixth pattern was correlated with the intake of chocolate, which is rich in manganese. Some observational studies highlighted an inverse association between chocolate intake and the risk of T2DM, although it is still uncertain which substances in chocolate are responsible for this association.…”

Bile acid composition regulates the manganese transporter Slc30a10 in intestine

“…Does BA-dependent regulation of Mn homeostasis have any impact on cardiometabolic disease? Some researchers have reported that patients with type-2 diabetes have plasma or serum Mn at levels higher than controls, while others have reported the opposite (73)(74)(75)(76). Because Mn levels must be maintained within a small range (31,44), it makes sense that both deficiency and excess of Mn would lead to negative consequences.…”

Micronutrient deficiency, a novel nutritional risk factor for insulin resistance and Syndrom X

“…The anti-oxidative effect of MnSOD protects the mitochondrial matrix from destruction by the ROS. Mn is also involved in normal immune response and is required in normal insulin synthesis and secretion [28]. Several studies have reported inverse association of serum Mn level with insulin activity and hence blood sugar level [29][30][31][32], in several countries.…”

“…Low meternal folate caused hyperinsulinemia and a reduction in adiponectin/ leptin ratio (marker of insulin sensitivity) in offspring [28], and vice versa.…”