2011
DOI: 10.1590/s0102-86502011000700004
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Preconditioning with L-alanyl-L-glutamine in a Mongolian Gerbil model of acute cerebral ischemia/reperfusion injury

Abstract: PURPOSE:To investigate the effect of L-alanyl-L-glutamine (L-Ala-Gln) preconditioning in an acute cerebral ischemia/reperfusion (I/R) model in gerbils. METHODS: Thirty-six Mongolian gerbils (Meriones unguiculatus), (60-100g), were randomized in 2 groups (n=18) and preconditioned with saline 2.0 ml (Group-S) or 0.75g/Kg of L-Ala-Gln, (Group-G) administered into the femoral vein 30 minutes prior to I/R. Each group was divided into three subgroups (n=6). Anesthetized animals (urethane, 1.5g/Kg, i.p.) were submitt… Show more

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Cited by 12 publications
(9 citation statements)
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“…Cerebral ischemia is a leading cause of death and disability worldwide and diabetes is a risk factor for ischemic cerebrovascular diseases [5]. Reperfusion following cerebral ischemia leads to the generation of pro-oxidant species which cause neuronal damage by acting directly on macromolecules, including proteins, lipids and DNA, or indirectly by interfering with cell signaling pathways and gene expression regulation [6]. Furthermore, several mechanisms are responsible for diabetic neuropathy including dyslipidemia, inflammation and apoptosis [4, 7, 8] .…”
Section: Introductionmentioning
confidence: 99%
“…Cerebral ischemia is a leading cause of death and disability worldwide and diabetes is a risk factor for ischemic cerebrovascular diseases [5]. Reperfusion following cerebral ischemia leads to the generation of pro-oxidant species which cause neuronal damage by acting directly on macromolecules, including proteins, lipids and DNA, or indirectly by interfering with cell signaling pathways and gene expression regulation [6]. Furthermore, several mechanisms are responsible for diabetic neuropathy including dyslipidemia, inflammation and apoptosis [4, 7, 8] .…”
Section: Introductionmentioning
confidence: 99%
“…Previous intravenous infusion of L-Ala-Gln in gerbils subjected to brain IR has been shown to decrease degeneration of the nucleus (pyknosis) and cell death (red neurons) in the cerebral tissue 6 . Preconditioning with mixtures of oils containing high ratio ω-6/ω-3 and low ω-9/ω-6 relationship protected brain neurons against I/R injury in an experimental model of global cerebral ischemia/reperfusion by decreasing red neurons count in hippocampus area CA3 1 .…”
Section: Red Neuron Countingmentioning
confidence: 99%
“…Previous infusion of L-Ala-Gln has been shown to reduce oxidative stress and brain cell nuclear degeneration in gerbils subjected to brain ischemia/reperfusion (I/R) injury 6 .…”
Section: Introductionmentioning
confidence: 99%
“…NLAG can directly scavenge, significantly improve the anti-apoptotic ability, and reduce the release of inflammatory factors, chemokines and adhesion molecules ( 5 , 6 ). In addition, NLAG has a protective effect on the kidney and liver against IRI ( 7 , 8 ). However, any protective effects and the underlying mechanism of NLAG on the myocardial IRI remain unclear.…”
Section: Introductionmentioning
confidence: 99%