Precedence of bone loss over changes in body composition and body fat distribution within a few years after menopause

Douchi, Tsutomu; Kosha, Shoichiro; Uto, Hirofumi; Oki, Toshimichi; Nakae, Mitsuhiro; Yoshimitsu, Nobuyuki; Nagata, Yukihiro

doi:10.1016/s0378-5122(03)00162-2

Cited by 35 publications

(22 citation statements)

References 14 publications

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“…10 It has been shown that BMD loss is an initial event during the menopausal process. 11 To investigate whether loss of LBM, increase in body fat mass, and the shift toward upper body fat distribution occur simultaneously or not, a longitudinal study appears to be appropriate. However, such a study would require a long-term approach throughout pre-and postmenopausal period, which would not be easy.…”

Section: Discussionmentioning

confidence: 99%

Precedence of the shift of body‐fat distribution over the change in body composition after menopause

Morita

Iwamoto

Mizuma

et al. 2006

J of Obstet and Gynaecol

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Section: Discussionmentioning

confidence: 99%

Precedence of the shift of body‐fat distribution over the change in body composition after menopause

Morita

Iwamoto

Mizuma

et al. 2006

J of Obstet and Gynaecol

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“…Moreover, abdominal obesity plays a critical role in the early stages of atherosclerotic process, mainly, modulating the activation of endothelial synthesis of cytokines and vascular smooth muscle cell proliferation [10,11]. The precocious stages of atherosclerosis are identified in a functional impairment of endothelial surface with a consequent impairment of arterial capacity to vasodilate and in the thickening of intima-media space [12,13].…”

Section: Introductionmentioning

confidence: 99%

“…It is known that menopausal age is characterized by hormonal changes as consequence of estrogenic fall mainly involving the bone metabolism, the redistribution of fat to the upper body depot, and the evidence of an increased risk for cardiovascular events [14] . On this basis, we decided to investigate in postmenopausal white women the potential links among OPG, as indicator of bone remodeling, abdominal fat accumulation, and the precocious features of atherosclerotic disease such as brachial endothelial function and the intima-media thickening (IMT) of large arteries.…”

Section: Introductionmentioning

confidence: 99%

Preclinical vascular damage in white postmenopausal women: the relevance of osteoprotegerin

et al. 2008

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“…Body weight is apparently mostly associated with postmenopausal BMD through weight bearing [8]. However, the constituents of body weight, lean and fat mass, also have their own metabolic and biomechanical associations with BMD and menopause [9,10]. While contributing to body weight, adipose tissue also elevates circulating estrogen levels during menopause and beyond since hormone concentrations remain high longer in obese postmenopausal women [11].…”

mentioning

confidence: 99%

Muscle Strength and Body Composition Are Clinical Indicators of Osteoporosis

et al. 2012

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We examined the role of muscle strength, lean tissue distribution, and overall body composition as indicators of osteoporosis (OP) in a pooled sample of 979 Finnish postmenopausal women (mean age 68.1 years) from the Kuopio Osteoporosis Risk Factor and Prevention study. Bone mineral density (BMD) at the femoral neck (FN) and total body composition were assessed by dual-energy X-ray absorptiometry scans. The women (n = 979) were divided into three groups according to WHO criteria, based on FN BMD T score: normal (n = 474), osteopenia (n = 468), and OP (n = 37). Soft tissue proportions, fat mass index (FMI, fat/height²), lean mass index (LMI, lean/height²), and appendicular skeletal muscle mass (ASM, (arms + legs)/height²) were calculated. Handgrip and knee extension strength measurements were made. OP subjects had significantly smaller LMI (p = 0.001), ASM (p = 0.001), grip strength (p < 0.0001), and knee extension strength (p < 0.05) but not FMI (p > 0.05) compared to other subjects. Grip and knee extension strength were 19 and 16 % weaker in OP women compared to others, respectively. The area under the receiver operating characteristic curve was 69 % for grip and 71 % for knee extension strength. In tissue proportions only LMI showed predictive power (63 %, p = 0.016). An overall linear association of LMI (R² = 0.007, p = 0.01) and FMI (R² = 0.028, p < 0.001) with FN BMD remained significant. In the multivariate model, after adjusting for age, grip strength, leg extension strength, FMI, LMI, number of medications, alcohol consumption, current smoking, dietary calcium intake, and hormone therapy, grip strength (adjusted OR = 0.899, 95 % CI 0.84-0.97, p < 0.01), leg extension strength (OR = 0.998, 95 % CI 0.99-1, p < 0.05), and years of hormone therapy (OR = 0.905, 95 % CI 0.82-1, p < 0.05) remained as significant determinants of OP. Muscle strength tests, especially grip strength, serve as an independent and useful tool for postmenopausal OP risk assessment. In addition, lean mass contributes to OP in this age group. Muscle strength and lean mass should be considered separately since both are independently associated with postmenopausal BMD.

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Precedence of bone loss over changes in body composition and body fat distribution within a few years after menopause

Cited by 35 publications

References 14 publications

Precedence of the shift of body‐fat distribution over the change in body composition after menopause

Precedence of the shift of body‐fat distribution over the change in body composition after menopause

Preclinical vascular damage in white postmenopausal women: the relevance of osteoprotegerin

Muscle Strength and Body Composition Are Clinical Indicators of Osteoporosis

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