Preclinical vascular damage in white postmenopausal women: the relevance of osteoprotegerin

Siepi, Donatella; Marchesi, Simona; Vaudo, Gaetano; Lupattelli, Graziana; Bagaglia, Francesco; Pirro, Matteo; Brozzetti, Matteo; Roscini, Anna Rita; Mannarino, Elmo

doi:10.1016/j.metabol.2007.10.005

Cited by 18 publications

(15 citation statements)

References 25 publications

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“…32,33 It is unclear whether osteoprotegerin should be considered to be an independent risk factor for cardiovascular diseases 11 or to be a defense mechanism for atherosclerotic progression. 30 There are several limitations to our study. The first limitation relates to its cross-sectional design, which implies that no causal inferences can be drawn.…”

Section: Discussionmentioning

confidence: 94%

Relation between intima-media thickness and bone mineral density in postmenopausal women: a cross-sectional study

et al. 2011

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Relation between intima-media thickness and bone mineral density in postmenopausal women: a cross-sectional study ABSTRACTCONTEXT AND OBJECTIVES: Controversy exists regarding the relationship between atherosclerosis and osteoporosis. The aim of this study was to determine the relationship between intima-media thickness (IMT) of the common carotid artery (CCA), presence of calcified atherosclerotic plaques and bone mineral density (BMD) evaluated by dual energy X-ray absorptiometry (DXA), in postmenopausal women. DESIGN AND SETTING:Cross-sectional study at Second Internal Medicine Clinic, Cluj-Napoca, Romania. METHODS:We studied the IMT (left and right CCA and mean IMT) and T-score (lumbar spine L2-L4, femoral neck and total hip) in 100 postmenopausal women (mean age 64.5 years). The presence of calcified atherosclerotic plaque and osteoporotic vertebral fractures was also noted. RESULTS:IMT in the left and right CCA and mean IMT were significantly associated with T-score measured for the lumbar spine L2-L4, femoral neck and total hip, with lower T-score, in the osteoporotic group than in the normal and osteopenic groups (P < 0.05). IMT had a significantly negative correlation with the lumbar spine T-score and femoral neck T-score; and mean IMT with lowest T-score. Mean IMT (P < 0.001), high blood pressure (P = 0.005) and osteoporotic vertebral fractures (P = 0.048) showed statistical significance regarding the likelihood of developing atherosclerotic plaque. CONCLUSIONS:In women referred for routine osteoporosis screening, the relationship between CCA, atherosclerosis and osteoporosis can be demonstrated using either cortical or trabecular BMD. Vertebral fractures may be considered to be a likelihood factor for atherosclerotic plaque development. RESUMÉN CONTEXTO Y OBJETIVOS:Hay controversias en cuanto a la relación entre la arterioesclerosis y la osteoporosis. El objetivo del estudio fue determinar la relación entre el espesor mío-intimal (EMI) de la arteria carótida común (ACC), la presencia de placas arterioescleróticas calcificadas, y la densidad mineral ósea (DMO) evaluada a través de absorciometría de rayos X de energía dual (DEXA) en mujeres posmenopáusicas. DISEÑO Y ENTORNO:Estudio transversal en la Segunda Clínica de Medicina Interna, Cluj-Napoca, Rumania. MÉTODOS:Hemos estudiado el EMI (ACC izquierda y derecha y EMI promedio) y el T-score (espina lumbar L2-L4, cuello femoral y cadera total) en 100 mujeres posmenopáusicas (edad promedia 64.5 años). Se ha observado también la presencia de las placas arterioescleróticas calcificadas y de la fractura vertebral osteoporótica.RESULTADOS: El EMI en ACC izquierda y derecha, como también el EMI promedio se ha asociado sobre todo con el T-score medido en la espina lumbar L2-L4, cuello femoral y cadera total o el valor más bajo del T-score, en el grupo osteoporótico, en comparación con el grupo normal y el osteopénico (P < 0.05). Se ha registrado una correlación significativamente negativa entre el EMI y el T-score de espina lumbar, el T-score del cuello femora...

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Section: Discussionmentioning

confidence: 94%

Relation between intima-media thickness and bone mineral density in postmenopausal women: a cross-sectional study

et al. 2011

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“…20,21) There have been very few studies on the relationship between the OPG and ADMA levels. 38,39) However, no previous studies found any relationship between the OPG and ADMA levels and the CIMT. The present study demonstrated, for the first time, that increased OPG levels were significantly related to the ADMA levels and the mCIMT in patients with CAD, thus suggesting that increased OPG levels were associated with endothelial function in patients with CAD.…”

Section: Elevated Opg Levels and Coronary Artery Diseases And Cimtmentioning

confidence: 98%

Osteoprotegerin is Associated With Endothelial Function and Predicts Early Carotid Atherosclerosis in Patients With Coronary Artery Disease

et al. 2015

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SummaryOsteoprotegerin (OPG) is a soluble glycoprotein belonging to the tumor necrosis factor receptor superfamily and is linked to vascular atherosclerosis and calcification. The carotid intima-media thickness (CIMT) correlates with carotid atherosclerosis and is a significant predictor of cardiovascular events. The OPG levels are associated with the CIMT in coronary artery disease (CAD) patients. However, the pathophysiological mechanisms underlying this pathway remain unclear. We investigated 114 CAD patients (89 men, 25 women; mean age: 68.7 ± 10.3 years) and measured the Gensini score (a marker of the extent of coronary atherosclerosis), the mean CIMT and the plasma levels of OPG and asymmetric dimethylarginine (ADMA; a marker of endothelial function). Early carotid atherosclerosis was defined as a mean CIMT > 1.0 mm. Only 33 of the 114 patients (28.9%) had early carotid atherosclerosis. Patients with early carotid atherosclerosis had higher OPG levels than those without. The OPG levels were found to be significantly associated with ADMA (r = 0.191, P = 0.046) and the mean CIMT (r = 0.319, P = 0.001), but not with the Gensini score. A receiver operating curve analysis revealed the optimal cut-off value of the OPG levels for predicting early carotid atherosclerosis to be 100 pmol/L. A multivariate logistic regression analysis showed OPG ≥ 100 pmol/L to be significantly and independently associated with early carotid atherosclerosis (odds ratio: 2.98, 95% confidence interval: 1.22-7.20, P = 0.017). These data indicate that OPG is significantly associated with endothelial function and predicts early carotid atherosclerosis in patients with CAD. (Int Heart J 2015; 56: 605-612)

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“…Decreased OPG levels were found in diabetic obese subjects [55,75], and insulin resistance in healthy obese subjects is associated with decreased serum OPG levels [63], whereas weight reduction therapy resulted in further decrease in OPG serum concentrations [75]. However, Siepi et al [76] suggested that OPG levels do not seem to be related with abdominal obesity in diabetic patients. Moreover, studies by Gannagé-Yared et al [77] indicated that OPG plasma levels did not differ between obese and non-obese subjects but OPG was statistically higher in 18 obese diabetic subjects compared with nondiabetics, although, after adjustment for age, OPG was not related to BMI in obese subjects.…”

Section: Opg and Obesity Lipid Profile And Metabolic Syndrome In Diamentioning

confidence: 99%

Osteoprotegerin and Diabetes-Associated Pathologies

Blázquez‐Medela

Jm²,

Martı́nez-Salgado³

2011

CMM

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Osteoprotegerin (OPG) is a member of the tumour necrosis factor receptor superfamily of cytokines which, in spite of being initially described as a strong anti-resorptive factor, has lately been considered as a possible link between bone and vascular disease. In the last few years, several studies have evidenced its close relationship with the development of diabetes. In this review, we analyse the role of OPG in diabetic patients and its links with the most relevant associated diseases such as atherosclerosis, hypertension, endothelial dysfunction and diabetic nephropathy, as well as its connection with related pathologies as fibrosis, obesity and metabolic syndrome.

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Preclinical vascular damage in white postmenopausal women: the relevance of osteoprotegerin

Cited by 18 publications

References 25 publications

Relation between intima-media thickness and bone mineral density in postmenopausal women: a cross-sectional study

Relation between intima-media thickness and bone mineral density in postmenopausal women: a cross-sectional study

Osteoprotegerin is Associated With Endothelial Function and Predicts Early Carotid Atherosclerosis in Patients With Coronary Artery Disease

Osteoprotegerin and Diabetes-Associated Pathologies

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