Pre-term cervical ripening and labor induction

Predicting factors for success of vaginal delivery in preterm induction with prostaglandin E2

“…For example, Abelin Tornblom et al [6] reported that labor induction at preterm (n=50) with PGE 2 gel was successful in 80% of cases and that there were no cases of tachysystole after insertion of PGE 2 . Notably, that study population consisted of 70% multiparous women.…”

“…Our study may be limited by the fact that we retrospectively collected data from pregnant women who underwent preterm induction, as did previous studies [612]. For example, an individual clinician may opt for CS without first attempting labor induction in some women.…”

“…According to a survey performed in our country, the PGE 2 vaginal pessary was found to be most frequently used for labor induction [4]. While the efficacy and safety issues of using PGE 2 (10 mg) at term pregnancy have been previously demonstrated in many studies [567], few studies have specifically addressed these issues in the context of preterm pregnancy.…”

“…Since preterm women, especially those in primiparity, usually have an unfavorable cervix, the rate of cesarean section (CS) due to induction failure is higher than at term [168], suggesting the importance of pre-induction cervical ripening in preterm gestation. On the contrary, possible side effects of PGs such as tachysystole or nonreassuring fetal heart rate may exert more deleterious effects on preterm fetuses [9].…”

Mode of delivery in pregnant women with hypertensive disorders and unfavorable cervix following induction of labor with vaginal application of prostaglandin E2

“…Nevertheless, within the study group, gestational age at delivery of <37 weeks was associated with 2.7‐fold higher risk of CS (Table V). However, others have found that induction of labor with prostaglandin gel can be successful in pre‐term pregnancy (CS rate of 20%) (19).…”