Effects of gestational age on prostaglandin EP receptor expression and functional involvement during in vitro contraction of the guinea pig uterus

Functional and Molecular Characterization of Hyposensitive Underactive Bladder Tissue and Urine in Streptozotocin-Induced Diabetic Rat

“…In guinea pig uterus, PGE2 was shown to be agonists for both EP1 and/or EP3 receptors, but was mostly acting via EP3 receptors [18]. Further studies are needed to clarify the precise link between PGE2 and EP1 and EP3 receptors with regard to the functional changes in urothelium and detrusor in the DM hyposensitive bladder.…”

“…The differences in the functions and localization of EP receptors, determine the influence of different EP receptors in micturition processing. EP1 and EP3 receptors expressed in smooth muscle and other tissues[15], [16], [17], [18] are known to cause contraction of non-diseased and cystopathic bladder [19]. However the role of differentially expressed EP1 and EP3 receptors in diabetes induced hyposensitive bladder is not clear.…”

The Prostanoid EP4 Receptor and Its Signaling Pathway

“…The EP4 receptor transcripts were expressed mainly in the luminal epithelium during periimplantation; they were increased in endometrial stromal cells and the glandular epithelium after pharmacological induction of pseudopregnancy Yang et al, 1997). EP4 transcripts were also present in the myometrium and remained unchanged throughout gestation in pregnant humans (Astle et al, 2005) and guinea pigs (Terry et al, 2008). EP3 receptor mRNA was predominantly expressed in the myometrium Yang et al, 1997).…”

“…In female reproductive organs such as the ovary and uterus, hormonal exposure induces expression of the EP subtypes in a cell type-specific manner. EP4 is expressed in the mouse ovary (Segi et al, 2003) and in the human (Milne et al, 2001;Astle et al, 2005), baboon , mouse Yang et al, 1997), rat (Blesson et al, 2012), and guinea pig (Terry et al, 2008) uterus, although Arosh et al (2003Arosh et al ( , 2004 reported that EP4 mRNA was undetectable in the bovine uterus.…”

Distribution and Function of Prostaglandin E2Receptors in Mouse Uterus: Translational Value for Human Reproduction

“…Due to the excitatory profile maintained during labour, it is likely that EP3 receptors are involved in the contractile force associated with parturition. In human, baboon and guinea-pig myometrium at term pregnancy and labour, EP3 receptor expression was similarly reported to be greater than that of EP2 and EP4 receptors (Matsumoto et al, 1997;Smith et al, 2001;Terry et al, 2008). This provides support to exploit EP3 receptors as a potential target for This article has not been copyedited and formatted.…”