Distribution and Function of Prostaglandin E<sub>2</sub>Receptors in Mouse Uterus: Translational Value for Human Reproduction

Fischer, Deborah; Griffiths, A.L.; Lui, SL; Sabar, Uzmah; Farrar, Diane; O’Donovan, Peter; Woodward, David F.; Marshall, Kay

doi:10.1124/jpet.119.263509

Cited by 5 publications

(5 citation statements)

References 64 publications

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“…For example, previous experiments have discovered that 15-methyl PGE2, or 16, 16-dimethyl PGE2 are more stable than PGE2 when administered intravenously, orally and intrajejunal 196 - 198 . Besides, PGE2 analogs have been widely used in clinical practice for cervical ripening and labor induction 199 . Another strategy available is the incorporation of engineered biomatrices for PGE2 control release by different approaches, such as encapsulation and chemical bonding ( Figure 7 C ).…”

Section: Pge2-based Therapeutic Strategies For Tissue Regenerationmentioning

confidence: 99%

Role of prostaglandin E2 in tissue repair and regeneration

et al. 2021

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Tissue regeneration following injury from disease or medical treatment still represents a challenge in regeneration medicine. Prostaglandin E2 (PGE2), which involves diverse physiological processes via E-type prostanoid (EP) receptor family, favors the regeneration of various organ systems following injury for its capabilities such as activation of endogenous stem cells, immune regulation, and angiogenesis. Understanding how PGE2 modulates tissue regeneration and then exploring how to elevate the regenerative efficiency of PGE2 will provide key insights into the tissue repair and regeneration processes by PGE2. In this review, we summarized the application of PGE2 to guide the regeneration of different tissues, including skin, heart, liver, kidney, intestine, bone, skeletal muscle, and hematopoietic stem cell regeneration. Moreover, we introduced PGE2-based therapeutic strategies to accelerate the recovery of impaired tissue or organs, including 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitors boosting endogenous PGE2 levels and biomaterial scaffolds to control PGE2 release.

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Section: Pge2-based Therapeutic Strategies For Tissue Regenerationmentioning

confidence: 99%

Role of prostaglandin E2 in tissue repair and regeneration

et al. 2021

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“…Increase of PGE-EP2 transmembrane receptors in the plasma of ASD patients of course is concomitant with high rate of brain EP2 receptors deletion which from the theoretical point of view could decrease the pro-inflammatory effects of PGE2. Excitingly, the neuroprotection of PGE2-EP2 has been documented only recently, while a distinction among PGE2 receptors had not been made previously [ 31 , 32 ]. Interestingly, Wu et al and others reported that EP1 and EP3 receptor signaling has inflammatory affects in vitro and in vivo models of Cerebral hypoperfusion, or inadequate blood flow in the brain [ 33 – 36 ], as a well-known disorder in most ASD patients [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values

et al. 2021

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Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interaction and restricted and repetitive behaviors. Neuroinflammation and abnormal lipid mediators have been identified in multiple investigations as an acknowledged etiological mechanism of ASD that can be targeted for therapeutic intervention. Methods In this study, multiple regression and combined receiver operating characteristic (ROC) curve analyses were used to determine the relationship between the neuroinflammatory marker α-synuclein and lipid mediator markers related to inflammation induction, such as cyclooxygenase-2 and prostaglandin-EP2 receptors, in the etiology of ASD. Additionally, the study aimed to determine the linear combination that maximizes the partial area under ROC curves for a set of markers. Forty children with ASD and 40 age- and sex-matched controls were enrolled in the study. Using ELISA, the levels of α-synuclein, cyclo-oxygenase-2, and prostaglandin-EP2 receptors were measured in the plasma of both groups. Statistical analyses using ROC curves and multiple and logistic regression models were performed. Results A remarkable increase in the area under the curve was observed using combined ROC curve analyses. Moreover, higher specificity and sensitivity of the combined markers were reported. Conclusions The present study indicates that measurement of the predictive value of selected biomarkers related to neuroinflammation and lipid metabolism in children with ASD using a ROC curve analysis should lead to a better understanding of the etiological mechanism of ASD and its link with metabolism. This information may facilitate early diagnosis and intervention.

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“…Studies on heart failure in female mice are limited. With respect to PGE2 specifically, studies are generally confined to the effects of PGE2 in pregnancy, [31][32][33] peripartum/postpartum cardiomyopathy, 34,35 and cardiac arrest. 36 To our knowledge, no 1 has investigated the effect of PGE2 on cardiac contractility in female mice.…”

Section: Discussionmentioning

confidence: 99%

Targeted Gene Deletion or Antagonism of the Prostaglandin E2 EP3 Receptor Protects Against Cardiac Injury Postmyocardial Infarction

Bryson,

Bhat,

Moore

et al. 2024

Circ: Heart Failure

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BACKGROUND: Prostaglandin E2 acts through 4 G-protein-coupled receptors (EP1–EP4). We previously reported that activation of the EP3 receptor reduces cardiac contractility, and its expression increases after a myocardial infarction (MI), mediating the reduction in cardiac function. In contrast, cardiac overexpression of the EP4 receptor in MI substantially improves cardiac function. Moreover, we recently reported that mice overexpressing EP3 have heart failure under basal conditions and worsened cardiac function after MI. Thus, the deleterious effects of the prostaglandin E2 EP receptors in the heart are mediated via its EP3 receptor. We, therefore, hypothesized that cardiomyocyte-specific knockout (CM-EP3 KO) or antagonism of the EP3 receptor protects the heart after MI. METHODS: To test our hypothesis, we made the novel CM-EP3 KO mouse and subjected CM-EP3 KO or controls to sham or MI surgery for 2 weeks. In separate experiments, C57BL/6 mice were subjected to 2 weeks of MI and treated with either the EP3 antagonist L798 106 or vehicle starting 3 days post-MI. RESULTS: CM-EP3 KO significantly prevented a decline in cardiac function after MI compared with WT animals and prevented an increase in hypertrophy and fibrosis. Excitingly, mice treated with L798 106 3 days after MI had significantly better cardiac function compared with vehicle-treated mice. CONCLUSIONS: Altogether, these data suggest that EP3 may play a direct role in regulating cardiac function, and pharmaceutical targeting of the EP3 receptor may be a therapeutic option in the treatment of heart failure.

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Distribution and Function of Prostaglandin E₂Receptors in Mouse Uterus: Translational Value for Human Reproduction

Abstract: In vitro fertilisation (IVF) Prostaglandin (PG) Section assignment: Drug Discovery and Translational Medicine This article has not been copyedited and formatted. The final version may differ from this version.

Cited by 5 publications

References 64 publications

Role of prostaglandin E2 in tissue repair and regeneration

Role of prostaglandin E2 in tissue repair and regeneration

Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values

Targeted Gene Deletion or Antagonism of the Prostaglandin E2 EP3 Receptor Protects Against Cardiac Injury Postmyocardial Infarction

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Distribution and Function of Prostaglandin E2Receptors in Mouse Uterus: Translational Value for Human Reproduction

Abstract: In vitro fertilisation (IVF) Prostaglandin (PG) Section assignment: Drug Discovery and Translational Medicine This article has not been copyedited and formatted. The final version may differ from this version.

Cited by 5 publications

References 64 publications

Role of prostaglandin E2 in tissue repair and regeneration

Role of prostaglandin E2 in tissue repair and regeneration

Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values

Targeted Gene Deletion or Antagonism of the Prostaglandin E2 EP3 Receptor Protects Against Cardiac Injury Postmyocardial Infarction

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Distribution and Function of Prostaglandin E₂Receptors in Mouse Uterus: Translational Value for Human Reproduction